Beneficial effect of adenosine during reperfusion following prolonged cardioplegic arrest
Study objective – The aim of the study was to investigate the effect of reperfusion with adenosine after prolonged cardioplegic arrest in the isolated working rat heart. Design – After 3 h of hypothermic (20°C) ischaemic arrest with multidose (every 30 min) infusions of St Thomas's Hospital car...
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| Veröffentlicht in: | Cardiovascular research 1990-03, Vol.24 (3), p.247-253 |
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| creator | Ledingham, Simon Katayama, Osamu Lachno, David Patel, Naina Yacoub, Magdi |
| description | Study objective – The aim of the study was to investigate the effect of reperfusion with adenosine after prolonged cardioplegic arrest in the isolated working rat heart. Design – After 3 h of hypothermic (20°C) ischaemic arrest with multidose (every 30 min) infusions of St Thomas's Hospital cardioplegic soluton No 1, rat hearts were reperfused with either ordinary perfusion fluid (Krebs-Henseleit bicarbonate buffer) or with additional adenosine (1 mg·litre−1) for 15 min prior to assessing recovery of function. Experimental material – Hearts (n=10 in each group) were obtained from male rats weighing 250-300 g. Measurements and main results – Mean coronary flow during the period of reperfusion was increased from 11.8(SEM 0.8) ml·min−1 with ordinary perfusate to 17(0.7) ml·min−1 with adenosine reperfusate (p |
| doi_str_mv | 10.1093/cvr/24.3.247 |
| format | Article |
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Design – After 3 h of hypothermic (20°C) ischaemic arrest with multidose (every 30 min) infusions of St Thomas's Hospital cardioplegic soluton No 1, rat hearts were reperfused with either ordinary perfusion fluid (Krebs-Henseleit bicarbonate buffer) or with additional adenosine (1 mg·litre−1) for 15 min prior to assessing recovery of function. Experimental material – Hearts (n=10 in each group) were obtained from male rats weighing 250-300 g. Measurements and main results – Mean coronary flow during the period of reperfusion was increased from 11.8(SEM 0.8) ml·min−1 with ordinary perfusate to 17(0.7) ml·min−1 with adenosine reperfusate (p<0.001). Mean recoveries of functional indices (as percent of preischaemic control values) in hearts receiving ordinary reperfusates v adenosine reperfusates were: peak aortic pressure 76.2(2.8)% υ 86.9(2.2)%, dP/dt 35.6(6.0)% υ 66.2(4.3)%, aortic flow 26.1(7.4)% υ 60.9(4.2)%, coronary flow 50.1(3.4% υ 75.6(3.6)%, and cardiac output 31.4(6.4)% υ 64.5(3.2)%. Recovery of all indices was significantly superior with adenosine than without (peak aortic pressure p<0.01, other indices p<0.001). A parallel series of experiments showed that the nucleotide content of both groups was similar at the end of the 15 min reperfusion period. Conclusions – Improvement in functional recovery occurs with low dose adenosine during reperfusion. This is likely to be due to an increase in coronary flow to the microvasculature rather than to an increase in intramyocardial ATP.</description><identifier>ISSN: 0008-6363</identifier><identifier>EISSN: 1755-3245</identifier><identifier>DOI: 10.1093/cvr/24.3.247</identifier><identifier>PMID: 2346959</identifier><identifier>CODEN: CVREAU</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>adenosine ; Adenosine - pharmacology ; Animals ; Biological and medical sciences ; Blood Pressure - drug effects ; Cardiac Output - drug effects ; cardioplegia ; Coronary Circulation - drug effects ; Heart - drug effects ; Heart Arrest, Induced ; In Vitro Techniques ; ischaemia ; Male ; Medical sciences ; Myocardial Reperfusion ; myocardium ; Myocardium - metabolism ; Nucleotides - metabolism ; Rats ; reperfusion ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the heart ; Time Factors</subject><ispartof>Cardiovascular research, 1990-03, Vol.24 (3), p.247-253</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c423t-3c3696b00a6b74df1ecdf325f68899906dadd00bb6eb584a1ba2f9d0ccf80be3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5089663$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2346959$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ledingham, Simon</creatorcontrib><creatorcontrib>Katayama, Osamu</creatorcontrib><creatorcontrib>Lachno, David</creatorcontrib><creatorcontrib>Patel, Naina</creatorcontrib><creatorcontrib>Yacoub, Magdi</creatorcontrib><title>Beneficial effect of adenosine during reperfusion following prolonged cardioplegic arrest</title><title>Cardiovascular research</title><addtitle>Cardiovasc Res</addtitle><description>Study objective – The aim of the study was to investigate the effect of reperfusion with adenosine after prolonged cardioplegic arrest in the isolated working rat heart. Design – After 3 h of hypothermic (20°C) ischaemic arrest with multidose (every 30 min) infusions of St Thomas's Hospital cardioplegic soluton No 1, rat hearts were reperfused with either ordinary perfusion fluid (Krebs-Henseleit bicarbonate buffer) or with additional adenosine (1 mg·litre−1) for 15 min prior to assessing recovery of function. Experimental material – Hearts (n=10 in each group) were obtained from male rats weighing 250-300 g. Measurements and main results – Mean coronary flow during the period of reperfusion was increased from 11.8(SEM 0.8) ml·min−1 with ordinary perfusate to 17(0.7) ml·min−1 with adenosine reperfusate (p<0.001). Mean recoveries of functional indices (as percent of preischaemic control values) in hearts receiving ordinary reperfusates v adenosine reperfusates were: peak aortic pressure 76.2(2.8)% υ 86.9(2.2)%, dP/dt 35.6(6.0)% υ 66.2(4.3)%, aortic flow 26.1(7.4)% υ 60.9(4.2)%, coronary flow 50.1(3.4% υ 75.6(3.6)%, and cardiac output 31.4(6.4)% υ 64.5(3.2)%. Recovery of all indices was significantly superior with adenosine than without (peak aortic pressure p<0.01, other indices p<0.001). A parallel series of experiments showed that the nucleotide content of both groups was similar at the end of the 15 min reperfusion period. Conclusions – Improvement in functional recovery occurs with low dose adenosine during reperfusion. This is likely to be due to an increase in coronary flow to the microvasculature rather than to an increase in intramyocardial ATP.</description><subject>adenosine</subject><subject>Adenosine - pharmacology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Cardiac Output - drug effects</subject><subject>cardioplegia</subject><subject>Coronary Circulation - drug effects</subject><subject>Heart - drug effects</subject><subject>Heart Arrest, Induced</subject><subject>In Vitro Techniques</subject><subject>ischaemia</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Myocardial Reperfusion</subject><subject>myocardium</subject><subject>Myocardium - metabolism</subject><subject>Nucleotides - metabolism</subject><subject>Rats</subject><subject>reperfusion</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the heart</subject><subject>Time Factors</subject><issn>0008-6363</issn><issn>1755-3245</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1PGzEQxa0KRAPl1mulPaCe2OD15_oIqG0qIXGAA3CxvPY4cuusg51t4b_HUaJcZjTzfnozegh97fC8w4pe2X_5irA5nRMmP6FZJzlvKWH8CM0wxn0rqKCf0Wkpf-rIuWQn6IRQJhRXM_R8AyP4YIOJDXgPdtMk3xgHYyphhMZNOYzLJsMasp9KSGPjU4zp_3a7zimmcQmusSa7kNYRlsE2Jmcomy_o2JtY4Hzfz9Djzx-Pt4v27v7X79vru9YyQjcttVQoMWBsxCCZ8x1Y5ynhXvS9UgoLZ5zDeBgEDLxnphsM8cpha32PB6Bn6PvOtj7zOtW7ehWKhRjNCGkqWipZbXpawcsdaHMqJYPX6xxWJr_rDuttkLoGqQnTtBZZ8W9732lYgTvA--SqfrHXTbEm-mxGG8oB47hXQmyvtjsslA28HWST_2ohqeR68fSiF3RB-IPAmtMPyBaMyg</recordid><startdate>19900301</startdate><enddate>19900301</enddate><creator>Ledingham, Simon</creator><creator>Katayama, Osamu</creator><creator>Lachno, David</creator><creator>Patel, Naina</creator><creator>Yacoub, Magdi</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900301</creationdate><title>Beneficial effect of adenosine during reperfusion following prolonged cardioplegic arrest</title><author>Ledingham, Simon ; Katayama, Osamu ; Lachno, David ; Patel, Naina ; Yacoub, Magdi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c423t-3c3696b00a6b74df1ecdf325f68899906dadd00bb6eb584a1ba2f9d0ccf80be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>adenosine</topic><topic>Adenosine - pharmacology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Cardiac Output - drug effects</topic><topic>cardioplegia</topic><topic>Coronary Circulation - drug effects</topic><topic>Heart - drug effects</topic><topic>Heart Arrest, Induced</topic><topic>In Vitro Techniques</topic><topic>ischaemia</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Myocardial Reperfusion</topic><topic>myocardium</topic><topic>Myocardium - metabolism</topic><topic>Nucleotides - metabolism</topic><topic>Rats</topic><topic>reperfusion</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the heart</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ledingham, Simon</creatorcontrib><creatorcontrib>Katayama, Osamu</creatorcontrib><creatorcontrib>Lachno, David</creatorcontrib><creatorcontrib>Patel, Naina</creatorcontrib><creatorcontrib>Yacoub, Magdi</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cardiovascular research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ledingham, Simon</au><au>Katayama, Osamu</au><au>Lachno, David</au><au>Patel, Naina</au><au>Yacoub, Magdi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Beneficial effect of adenosine during reperfusion following prolonged cardioplegic arrest</atitle><jtitle>Cardiovascular research</jtitle><addtitle>Cardiovasc Res</addtitle><date>1990-03-01</date><risdate>1990</risdate><volume>24</volume><issue>3</issue><spage>247</spage><epage>253</epage><pages>247-253</pages><issn>0008-6363</issn><eissn>1755-3245</eissn><coden>CVREAU</coden><abstract>Study objective – The aim of the study was to investigate the effect of reperfusion with adenosine after prolonged cardioplegic arrest in the isolated working rat heart. Design – After 3 h of hypothermic (20°C) ischaemic arrest with multidose (every 30 min) infusions of St Thomas's Hospital cardioplegic soluton No 1, rat hearts were reperfused with either ordinary perfusion fluid (Krebs-Henseleit bicarbonate buffer) or with additional adenosine (1 mg·litre−1) for 15 min prior to assessing recovery of function. Experimental material – Hearts (n=10 in each group) were obtained from male rats weighing 250-300 g. Measurements and main results – Mean coronary flow during the period of reperfusion was increased from 11.8(SEM 0.8) ml·min−1 with ordinary perfusate to 17(0.7) ml·min−1 with adenosine reperfusate (p<0.001). Mean recoveries of functional indices (as percent of preischaemic control values) in hearts receiving ordinary reperfusates v adenosine reperfusates were: peak aortic pressure 76.2(2.8)% υ 86.9(2.2)%, dP/dt 35.6(6.0)% υ 66.2(4.3)%, aortic flow 26.1(7.4)% υ 60.9(4.2)%, coronary flow 50.1(3.4% υ 75.6(3.6)%, and cardiac output 31.4(6.4)% υ 64.5(3.2)%. Recovery of all indices was significantly superior with adenosine than without (peak aortic pressure p<0.01, other indices p<0.001). A parallel series of experiments showed that the nucleotide content of both groups was similar at the end of the 15 min reperfusion period. Conclusions – Improvement in functional recovery occurs with low dose adenosine during reperfusion. This is likely to be due to an increase in coronary flow to the microvasculature rather than to an increase in intramyocardial ATP.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>2346959</pmid><doi>10.1093/cvr/24.3.247</doi><tpages>7</tpages></addata></record> |
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| ispartof | Cardiovascular research, 1990-03, Vol.24 (3), p.247-253 |
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| subjects | adenosine Adenosine - pharmacology Animals Biological and medical sciences Blood Pressure - drug effects Cardiac Output - drug effects cardioplegia Coronary Circulation - drug effects Heart - drug effects Heart Arrest, Induced In Vitro Techniques ischaemia Male Medical sciences Myocardial Reperfusion myocardium Myocardium - metabolism Nucleotides - metabolism Rats reperfusion Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the heart Time Factors |
| title | Beneficial effect of adenosine during reperfusion following prolonged cardioplegic arrest |
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