The Synthesis and Antifungal Activity of Nitrogen Containing Hemiaminal Ethers of LY303366

LY303366, currently in phase II clinical trials, is a semisynthetic, broad spectrum, fungicidal agent derived through extensive structure-activity relationship (SAR) studies based on the echinocandin B (ECB) nucleus. Possession of such potent activity against clinically important fungi such as Asper...

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Veröffentlicht in:	Journal of antibiotics 1998/02/25, Vol.51(2), pp.239-242
Hauptverfasser:	JAMISON, JAMES A., LAGRANDEUR, LISA M., RODRIGUEZ, MICHAEL J., TURNER, WILLIAM W., ZECKNER, DOUGLAS J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anidulafungin Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - chemical synthesis Antifungal Agents - chemistry Antifungal Agents - pharmacology Aspergillus fumigatus Biological and medical sciences Candida albicans Candida parapsilosis Candidiasis - drug therapy Echinocandins Male Medical sciences Mice Mice, Inbred ICR Microbial Sensitivity Tests Peptides, Cyclic - chemical synthesis Peptides, Cyclic - chemistry Peptides, Cyclic - pharmacology Pharmacology. Drug treatments Structure-Activity Relationship
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