Ketamine in hypovolemic dogs
The cardiopulmonary consequences of hemorrhagic hypovolemia and the subsequent administration of ketamine were evaluated in eight dogs; five additional dogs served as controls. Heart rate (HR), systemic vascular resistance, breathing rate, minute ventilation (VE), Pao2, alveolar-arterial oxygen tens...
Gespeichert in:
| Veröffentlicht in: | Critical care medicine 1990-06, Vol.18 (6), p.625-629 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 629 |
|---|---|
| container_issue | 6 |
| container_start_page | 625 |
| container_title | Critical care medicine |
| container_volume | 18 |
| creator | HASKINS, STEVE C PATZ, JOHN D |
| description | The cardiopulmonary consequences of hemorrhagic hypovolemia and the subsequent administration of ketamine were evaluated in eight dogs; five additional dogs served as controls. Heart rate (HR), systemic vascular resistance, breathing rate, minute ventilation (VE), Pao2, alveolar-arterial oxygen tension gradient, and oxygen extraction ratio increased, while arterial and pulmonary pressures, CVP, cardiac output, oxygen transport, P o2, Paco2, mixed venous oxygen content, bicarbonate, and base deficit decreased in response to hypovolemia. Ketamine administration was associated with a significant increase in HR, arterial and pulmonary BP, and Paco2, and a significant decrease in VE (transient), Pao2 (transient), and pH. Ketamine supported cardiovascular function well, did not impair tissue oxygenation, and caused only transient respiratory depression in these hypovolemic dogs. |
| doi_str_mv | 10.1097/00003246-199006000-00010 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79793861</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>79793861</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3840-eaa55a1405015253764268a22bbbc4b44aa3eae56f341401582be3f0039cf2c33</originalsourceid><addsrcrecordid>eNp1kUtPwzAMgCMEGmPwD0DqAXErJHHSNkc08RKTuMA5SjOXFdJ2JB3T_j0ZK7sRyYosf87jMyEJo9eMqvyGxgVcZClTitIsZmkMRg_ImEmICVdwSMaUKpqCUHBMTkL4iISQOYzIiDPGcpmNyfkz9qapW0zqNllslt1357CpbTLv3sMpOaqMC3g27BPydn_3On1MZy8PT9PbWWqhEDRFY6Q0TFBJmeQS8kzwrDCcl2VpRSmEMYAGZVaBiBSTBS8RqvgDZStuASbkanfu0ndfKwy9bupg0TnTYrcKOle5giJjESx2oPVdCB4rvfR1Y_xGM6q3YvSfGL0Xo3_FxNaL4Y5V2eB83ziYiPXLoW6CNa7yprV12GOSFkrx7VPFDlt3rkcfPt1qjV4v0Lh-of8bC_wAg_x3MA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79793861</pqid></control><display><type>article</type><title>Ketamine in hypovolemic dogs</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>HASKINS, STEVE C ; PATZ, JOHN D</creator><creatorcontrib>HASKINS, STEVE C ; PATZ, JOHN D</creatorcontrib><description>The cardiopulmonary consequences of hemorrhagic hypovolemia and the subsequent administration of ketamine were evaluated in eight dogs; five additional dogs served as controls. Heart rate (HR), systemic vascular resistance, breathing rate, minute ventilation (VE), Pao2, alveolar-arterial oxygen tension gradient, and oxygen extraction ratio increased, while arterial and pulmonary pressures, CVP, cardiac output, oxygen transport, P o2, Paco2, mixed venous oxygen content, bicarbonate, and base deficit decreased in response to hypovolemia. Ketamine administration was associated with a significant increase in HR, arterial and pulmonary BP, and Paco2, and a significant decrease in VE (transient), Pao2 (transient), and pH. Ketamine supported cardiovascular function well, did not impair tissue oxygenation, and caused only transient respiratory depression in these hypovolemic dogs.</description><identifier>ISSN: 0090-3493</identifier><identifier>EISSN: 1530-0293</identifier><identifier>DOI: 10.1097/00003246-199006000-00010</identifier><identifier>PMID: 2111756</identifier><identifier>CODEN: CCMDC7</identifier><language>eng</language><publisher>Hagerstown, MD: Williams & Wilkins</publisher><subject>Acid-Base Equilibrium - drug effects ; Anesthetics. Neuromuscular blocking agents ; Animals ; Biological and medical sciences ; Carbon Dioxide - blood ; Dogs ; Hemodynamics - drug effects ; Ketamine - pharmacology ; Medical sciences ; Neuropharmacology ; Oxygen - blood ; Pharmacology. Drug treatments ; Respiration - drug effects ; Shock - blood ; Shock - physiopathology</subject><ispartof>Critical care medicine, 1990-06, Vol.18 (6), p.625-629</ispartof><rights>Williams & Wilkins 1990. All Rights Reserved.</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3840-eaa55a1405015253764268a22bbbc4b44aa3eae56f341401582be3f0039cf2c33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5089923$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2111756$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HASKINS, STEVE C</creatorcontrib><creatorcontrib>PATZ, JOHN D</creatorcontrib><title>Ketamine in hypovolemic dogs</title><title>Critical care medicine</title><addtitle>Crit Care Med</addtitle><description>The cardiopulmonary consequences of hemorrhagic hypovolemia and the subsequent administration of ketamine were evaluated in eight dogs; five additional dogs served as controls. Heart rate (HR), systemic vascular resistance, breathing rate, minute ventilation (VE), Pao2, alveolar-arterial oxygen tension gradient, and oxygen extraction ratio increased, while arterial and pulmonary pressures, CVP, cardiac output, oxygen transport, P o2, Paco2, mixed venous oxygen content, bicarbonate, and base deficit decreased in response to hypovolemia. Ketamine administration was associated with a significant increase in HR, arterial and pulmonary BP, and Paco2, and a significant decrease in VE (transient), Pao2 (transient), and pH. Ketamine supported cardiovascular function well, did not impair tissue oxygenation, and caused only transient respiratory depression in these hypovolemic dogs.</description><subject>Acid-Base Equilibrium - drug effects</subject><subject>Anesthetics. Neuromuscular blocking agents</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Carbon Dioxide - blood</subject><subject>Dogs</subject><subject>Hemodynamics - drug effects</subject><subject>Ketamine - pharmacology</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>Oxygen - blood</subject><subject>Pharmacology. Drug treatments</subject><subject>Respiration - drug effects</subject><subject>Shock - blood</subject><subject>Shock - physiopathology</subject><issn>0090-3493</issn><issn>1530-0293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtPwzAMgCMEGmPwD0DqAXErJHHSNkc08RKTuMA5SjOXFdJ2JB3T_j0ZK7sRyYosf87jMyEJo9eMqvyGxgVcZClTitIsZmkMRg_ImEmICVdwSMaUKpqCUHBMTkL4iISQOYzIiDPGcpmNyfkz9qapW0zqNllslt1357CpbTLv3sMpOaqMC3g27BPydn_3On1MZy8PT9PbWWqhEDRFY6Q0TFBJmeQS8kzwrDCcl2VpRSmEMYAGZVaBiBSTBS8RqvgDZStuASbkanfu0ndfKwy9bupg0TnTYrcKOle5giJjESx2oPVdCB4rvfR1Y_xGM6q3YvSfGL0Xo3_FxNaL4Y5V2eB83ziYiPXLoW6CNa7yprV12GOSFkrx7VPFDlt3rkcfPt1qjV4v0Lh-of8bC_wAg_x3MA</recordid><startdate>199006</startdate><enddate>199006</enddate><creator>HASKINS, STEVE C</creator><creator>PATZ, JOHN D</creator><general>Williams & Wilkins</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199006</creationdate><title>Ketamine in hypovolemic dogs</title><author>HASKINS, STEVE C ; PATZ, JOHN D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3840-eaa55a1405015253764268a22bbbc4b44aa3eae56f341401582be3f0039cf2c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Acid-Base Equilibrium - drug effects</topic><topic>Anesthetics. Neuromuscular blocking agents</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Carbon Dioxide - blood</topic><topic>Dogs</topic><topic>Hemodynamics - drug effects</topic><topic>Ketamine - pharmacology</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Oxygen - blood</topic><topic>Pharmacology. Drug treatments</topic><topic>Respiration - drug effects</topic><topic>Shock - blood</topic><topic>Shock - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HASKINS, STEVE C</creatorcontrib><creatorcontrib>PATZ, JOHN D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Critical care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HASKINS, STEVE C</au><au>PATZ, JOHN D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ketamine in hypovolemic dogs</atitle><jtitle>Critical care medicine</jtitle><addtitle>Crit Care Med</addtitle><date>1990-06</date><risdate>1990</risdate><volume>18</volume><issue>6</issue><spage>625</spage><epage>629</epage><pages>625-629</pages><issn>0090-3493</issn><eissn>1530-0293</eissn><coden>CCMDC7</coden><abstract>The cardiopulmonary consequences of hemorrhagic hypovolemia and the subsequent administration of ketamine were evaluated in eight dogs; five additional dogs served as controls. Heart rate (HR), systemic vascular resistance, breathing rate, minute ventilation (VE), Pao2, alveolar-arterial oxygen tension gradient, and oxygen extraction ratio increased, while arterial and pulmonary pressures, CVP, cardiac output, oxygen transport, P o2, Paco2, mixed venous oxygen content, bicarbonate, and base deficit decreased in response to hypovolemia. Ketamine administration was associated with a significant increase in HR, arterial and pulmonary BP, and Paco2, and a significant decrease in VE (transient), Pao2 (transient), and pH. Ketamine supported cardiovascular function well, did not impair tissue oxygenation, and caused only transient respiratory depression in these hypovolemic dogs.</abstract><cop>Hagerstown, MD</cop><pub>Williams & Wilkins</pub><pmid>2111756</pmid><doi>10.1097/00003246-199006000-00010</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0090-3493 |
| ispartof | Critical care medicine, 1990-06, Vol.18 (6), p.625-629 |
| issn | 0090-3493 1530-0293 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79793861 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Acid-Base Equilibrium - drug effects Anesthetics. Neuromuscular blocking agents Animals Biological and medical sciences Carbon Dioxide - blood Dogs Hemodynamics - drug effects Ketamine - pharmacology Medical sciences Neuropharmacology Oxygen - blood Pharmacology. Drug treatments Respiration - drug effects Shock - blood Shock - physiopathology |
| title | Ketamine in hypovolemic dogs |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T18%3A17%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Ketamine%20in%20hypovolemic%20dogs&rft.jtitle=Critical%20care%20medicine&rft.au=HASKINS,%20STEVE%20C&rft.date=1990-06&rft.volume=18&rft.issue=6&rft.spage=625&rft.epage=629&rft.pages=625-629&rft.issn=0090-3493&rft.eissn=1530-0293&rft.coden=CCMDC7&rft_id=info:doi/10.1097/00003246-199006000-00010&rft_dat=%3Cproquest_cross%3E79793861%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=79793861&rft_id=info:pmid/2111756&rfr_iscdi=true |