Pharmacophoric requirements for cannabinoid side chains: multiple bond and C1'-substituted delta 8-tetrahydrocannabinols

Accumulated evidence indicates that within the cannabinoid structure the aliphatic side chain plays a pivotal role in determining cannabimimetic activity. We describe the synthesis and affinities for the CB1 and CB2 receptors of a series of novel delta 8-THC analogues in which the side-chain pharmac...

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Veröffentlicht in:	Journal of medicinal chemistry 1998-03, Vol.41 (7), p.1195-1200
Hauptverfasser:	Papahatjis, D P, Kourouli, T, Abadji, V, Goutopoulos, A, Makriyannis, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - drug effects Brain - metabolism Cannabinoids - chemical synthesis Cannabinoids - chemistry Cannabinoids - pharmacology Dronabinol - analogs & derivatives Dronabinol - chemical synthesis Dronabinol - chemistry Dronabinol - pharmacology Rats Receptor, Cannabinoid, CB2 Receptors, Cannabinoid Receptors, Drug - drug effects Structure-Activity Relationship
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