Kinetics, stoichiometry and role of the Na-Ca exchange mechanism in isolated cardiac myocytes

COMPELLING evidence has existed for more than a decade for a sodium/calcium (Na–Ca) exchange mechanism in the surface membrane of mammalian heart muscle cells 1–3 which exchanges about three sodium ions for each calcium ion 4–6 . Although it is known that cardiac muscle contraction is regulated by a...

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Veröffentlicht in:	Nature (London) 1990-06, Vol.345 (6276), p.618-621
Hauptverfasser:	Crespo, Lynn M, Grantham, Christopher J, Cannell, Mark B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Calcium Calcium (intracellular) Calcium (reticular) Calcium - metabolism Calcium ions Cardiac muscle Cardiomyocytes Carrier Proteins - metabolism Depolarization Electrochemistry Equilibrium Extrusion rate Fluorescent Dyes Guinea Pigs Heart Humanities and Social Sciences Indo-1 Indoles ion exchange Kinetics letter Membrane Potentials multidisciplinary Muscle contraction Muscles Muscular function Myocardium - metabolism Myocytes Na+/Ca2+ exchanger Physiology Sarcoplasmic reticulum Science Science (multidisciplinary) Sodium Sodium - metabolism Sodium channels (voltage-gated) Sodium-Calcium Exchanger Stoichiometry Time constant
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