Abnormal Papanicolaou Smear: A Population-based Study of Risk Factors in Greenlandic and Danish Women
Possible risk factors for abnormal Papanicolaou smear were investigated in a population-based cross-sectional study. From Nuuk (Greenland) and Nykebing Falster (Denmark), random samples of 800 women aged 20-39 years were drawn. Totals of 586 and 661 women were included in Greenland and Denmark, resp...
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| Veröffentlicht in: | Acta obstetricia et gynecologica Scandinavica 1990, Vol.69 (1), p.79-86 |
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| container_title | Acta obstetricia et gynecologica Scandinavica |
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| creator | Kjær, Susanne K. Poll, Paul Jensen, Henning Engholm, Gerda Haugaard, Birthe J. Teisen, Chantal Christensen, Rene B. Möller, Knud A. Vestergaard, Bent Faber Villiers, Ethel-Michele de Lynge, Elsebeth Jensen, Ole M. |
| description | Possible risk factors for abnormal Papanicolaou smear were investigated in a population-based cross-sectional study. From Nuuk (Greenland) and Nykebing Falster (Denmark), random samples of 800 women aged 20-39 years were drawn. Totals of 586 and 661 women were included in Greenland and Denmark, respectively. All women went through a personal interview, and had a gynecologic examination including a PAP smear and cervical swab for HPV analysis. A blood sample was taken for analysis of HSV type specific antibodies. Multiple sexual partners was the most important risk factor for abnormal cervical cytology (OR = 4.2). An infectious etiology was also indirectly supported by a relatively protective effect of barrier contraceptive methods (OR = 0.6). The simultaneous finding of HPV 16/18 as a significant risk factor (OR = 2.4) cannot be taken uncritically as support for a causal effect of this HPV type, since such a relationship between cytological changes of the cervix and HPV infection could also emerge if the positive PAP smear was not just a measure of intra-epithelial neoplasia but also an expression of the infection itself on the cervix. |
| doi_str_mv | 10.3109/00016349009021044 |
| format | Article |
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From Nuuk (Greenland) and Nykebing Falster (Denmark), random samples of 800 women aged 20-39 years were drawn. Totals of 586 and 661 women were included in Greenland and Denmark, respectively. All women went through a personal interview, and had a gynecologic examination including a PAP smear and cervical swab for HPV analysis. A blood sample was taken for analysis of HSV type specific antibodies. Multiple sexual partners was the most important risk factor for abnormal cervical cytology (OR = 4.2). An infectious etiology was also indirectly supported by a relatively protective effect of barrier contraceptive methods (OR = 0.6). The simultaneous finding of HPV 16/18 as a significant risk factor (OR = 2.4) cannot be taken uncritically as support for a causal effect of this HPV type, since such a relationship between cytological changes of the cervix and HPV infection could also emerge if the positive PAP smear was not just a measure of intra-epithelial neoplasia but also an expression of the infection itself on the cervix.</description><identifier>ISSN: 0001-6349</identifier><identifier>EISSN: 1600-0412</identifier><identifier>DOI: 10.3109/00016349009021044</identifier><identifier>PMID: 2161172</identifier><identifier>CODEN: AOGSAE</identifier><language>eng</language><publisher>Oxford, UK: Informa UK Ltd</publisher><subject>Adult ; Biological and medical sciences ; Contraception Behavior ; Cross-Sectional Studies ; Denmark ; Female ; Female genital diseases ; Greenland ; Gynecology. Andrology. Obstetrics ; Herpes Genitalis - complications ; Humans ; Medical sciences ; Non tumoral diseases ; Papanicolaou Test ; Papillomaviridae ; Risk Factors ; Sexual Behavior ; Smoking ; Tumor Virus Infections - complications ; Uterine Cervical Dysplasia - diagnosis ; Uterine Cervical Dysplasia - etiology ; Uterine Cervical Neoplasms - etiology ; Vaginal Smears</subject><ispartof>Acta obstetricia et gynecologica Scandinavica, 1990, Vol.69 (1), p.79-86</ispartof><rights>1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1990</rights><rights>1990 Acta Obstet Gynecol Scand</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4637-1c16d738265d8a3cc5b69ec7c3a15805062ad361aac3327598997ae2e867e9ee3</citedby><cites>FETCH-LOGICAL-c4637-1c16d738265d8a3cc5b69ec7c3a15805062ad361aac3327598997ae2e867e9ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.3109%2F00016349009021044$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.3109%2F00016349009021044$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,4024,27923,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19401367$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2161172$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kjær, Susanne K.</creatorcontrib><creatorcontrib>Poll, Paul</creatorcontrib><creatorcontrib>Jensen, Henning</creatorcontrib><creatorcontrib>Engholm, Gerda</creatorcontrib><creatorcontrib>Haugaard, Birthe J.</creatorcontrib><creatorcontrib>Teisen, Chantal</creatorcontrib><creatorcontrib>Christensen, Rene B.</creatorcontrib><creatorcontrib>Möller, Knud A.</creatorcontrib><creatorcontrib>Vestergaard, Bent Faber</creatorcontrib><creatorcontrib>Villiers, Ethel-Michele de</creatorcontrib><creatorcontrib>Lynge, Elsebeth</creatorcontrib><creatorcontrib>Jensen, Ole M.</creatorcontrib><title>Abnormal Papanicolaou Smear: A Population-based Study of Risk Factors in Greenlandic and Danish Women</title><title>Acta obstetricia et gynecologica Scandinavica</title><addtitle>Acta Obstet Gynecol Scand</addtitle><description>Possible risk factors for abnormal Papanicolaou smear were investigated in a population-based cross-sectional study. From Nuuk (Greenland) and Nykebing Falster (Denmark), random samples of 800 women aged 20-39 years were drawn. Totals of 586 and 661 women were included in Greenland and Denmark, respectively. All women went through a personal interview, and had a gynecologic examination including a PAP smear and cervical swab for HPV analysis. A blood sample was taken for analysis of HSV type specific antibodies. Multiple sexual partners was the most important risk factor for abnormal cervical cytology (OR = 4.2). An infectious etiology was also indirectly supported by a relatively protective effect of barrier contraceptive methods (OR = 0.6). The simultaneous finding of HPV 16/18 as a significant risk factor (OR = 2.4) cannot be taken uncritically as support for a causal effect of this HPV type, since such a relationship between cytological changes of the cervix and HPV infection could also emerge if the positive PAP smear was not just a measure of intra-epithelial neoplasia but also an expression of the infection itself on the cervix.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Contraception Behavior</subject><subject>Cross-Sectional Studies</subject><subject>Denmark</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Greenland</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Herpes Genitalis - complications</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Non tumoral diseases</subject><subject>Papanicolaou Test</subject><subject>Papillomaviridae</subject><subject>Risk Factors</subject><subject>Sexual Behavior</subject><subject>Smoking</subject><subject>Tumor Virus Infections - complications</subject><subject>Uterine Cervical Dysplasia - diagnosis</subject><subject>Uterine Cervical Dysplasia - etiology</subject><subject>Uterine Cervical Neoplasms - etiology</subject><subject>Vaginal Smears</subject><issn>0001-6349</issn><issn>1600-0412</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV9v0zAUxS0EGt3gA_CA5Bd4C_hPYsfwVA1akCpW0cEerVvnVs2WxJ2diPXb46jReECCF1vW-Z1j-1xCXnH2TnJm3jPGuJK5YcwwwVmePyEzrhjLWM7FUzIb9WwEnpPzGG_TSei8PCNngivOtZgRnG87H1po6BoO0NXON-AHumkRwgc6p2t_GBroa99lW4hY0U0_VEfqd_R7He_oAlzvQ6R1R5cBsWugq2pH00o_pbS4pze-xe4FebaDJuLLab8gPxafry-_ZKur5dfL-SpzuZI6446rSstSqKIqQTpXbJVBp50EXpSsYEpAJRUHcFIKXZjSGA0osFQaDaK8IG9PuYfg7weMvW3r6LBJz0I_RKuNNoIXIoH8BLrgYwy4s4dQtxCOljM7Vmv_qjZ5Xk_hw7bF6tExdZn0N5MO0UGzC9C5Ov4JNjnjUunEqRP3q27w-P-L7fxqqUw5GrOTsY49PjwaIdzZFKsLe_Ntaa9X65-bfLGx68R_nPhuN854j9D0ewcB7a0fQpcm8Y_v_gYnRLA4</recordid><startdate>1990</startdate><enddate>1990</enddate><creator>Kjær, Susanne K.</creator><creator>Poll, Paul</creator><creator>Jensen, Henning</creator><creator>Engholm, Gerda</creator><creator>Haugaard, Birthe J.</creator><creator>Teisen, Chantal</creator><creator>Christensen, Rene B.</creator><creator>Möller, Knud A.</creator><creator>Vestergaard, Bent Faber</creator><creator>Villiers, Ethel-Michele de</creator><creator>Lynge, Elsebeth</creator><creator>Jensen, Ole M.</creator><general>Informa UK Ltd</general><general>Blackwell Publishing Ltd</general><general>Taylor & Francis</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1990</creationdate><title>Abnormal Papanicolaou Smear: A Population-based Study of Risk Factors in Greenlandic and Danish Women</title><author>Kjær, Susanne K. ; Poll, Paul ; Jensen, Henning ; Engholm, Gerda ; Haugaard, Birthe J. ; Teisen, Chantal ; Christensen, Rene B. ; Möller, Knud A. ; Vestergaard, Bent Faber ; Villiers, Ethel-Michele de ; Lynge, Elsebeth ; Jensen, Ole M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4637-1c16d738265d8a3cc5b69ec7c3a15805062ad361aac3327598997ae2e867e9ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Contraception Behavior</topic><topic>Cross-Sectional Studies</topic><topic>Denmark</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Greenland</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Herpes Genitalis - complications</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Non tumoral diseases</topic><topic>Papanicolaou Test</topic><topic>Papillomaviridae</topic><topic>Risk Factors</topic><topic>Sexual Behavior</topic><topic>Smoking</topic><topic>Tumor Virus Infections - complications</topic><topic>Uterine Cervical Dysplasia - diagnosis</topic><topic>Uterine Cervical Dysplasia - etiology</topic><topic>Uterine Cervical Neoplasms - etiology</topic><topic>Vaginal Smears</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kjær, Susanne K.</creatorcontrib><creatorcontrib>Poll, Paul</creatorcontrib><creatorcontrib>Jensen, Henning</creatorcontrib><creatorcontrib>Engholm, Gerda</creatorcontrib><creatorcontrib>Haugaard, Birthe J.</creatorcontrib><creatorcontrib>Teisen, Chantal</creatorcontrib><creatorcontrib>Christensen, Rene B.</creatorcontrib><creatorcontrib>Möller, Knud A.</creatorcontrib><creatorcontrib>Vestergaard, Bent Faber</creatorcontrib><creatorcontrib>Villiers, Ethel-Michele de</creatorcontrib><creatorcontrib>Lynge, Elsebeth</creatorcontrib><creatorcontrib>Jensen, Ole M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta obstetricia et gynecologica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kjær, Susanne K.</au><au>Poll, Paul</au><au>Jensen, Henning</au><au>Engholm, Gerda</au><au>Haugaard, Birthe J.</au><au>Teisen, Chantal</au><au>Christensen, Rene B.</au><au>Möller, Knud A.</au><au>Vestergaard, Bent Faber</au><au>Villiers, Ethel-Michele de</au><au>Lynge, Elsebeth</au><au>Jensen, Ole M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Abnormal Papanicolaou Smear: A Population-based Study of Risk Factors in Greenlandic and Danish Women</atitle><jtitle>Acta obstetricia et gynecologica Scandinavica</jtitle><addtitle>Acta Obstet Gynecol Scand</addtitle><date>1990</date><risdate>1990</risdate><volume>69</volume><issue>1</issue><spage>79</spage><epage>86</epage><pages>79-86</pages><issn>0001-6349</issn><eissn>1600-0412</eissn><coden>AOGSAE</coden><abstract>Possible risk factors for abnormal Papanicolaou smear were investigated in a population-based cross-sectional study. From Nuuk (Greenland) and Nykebing Falster (Denmark), random samples of 800 women aged 20-39 years were drawn. Totals of 586 and 661 women were included in Greenland and Denmark, respectively. All women went through a personal interview, and had a gynecologic examination including a PAP smear and cervical swab for HPV analysis. A blood sample was taken for analysis of HSV type specific antibodies. Multiple sexual partners was the most important risk factor for abnormal cervical cytology (OR = 4.2). An infectious etiology was also indirectly supported by a relatively protective effect of barrier contraceptive methods (OR = 0.6). The simultaneous finding of HPV 16/18 as a significant risk factor (OR = 2.4) cannot be taken uncritically as support for a causal effect of this HPV type, since such a relationship between cytological changes of the cervix and HPV infection could also emerge if the positive PAP smear was not just a measure of intra-epithelial neoplasia but also an expression of the infection itself on the cervix.</abstract><cop>Oxford, UK</cop><pub>Informa UK Ltd</pub><pmid>2161172</pmid><doi>10.3109/00016349009021044</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0001-6349 |
| ispartof | Acta obstetricia et gynecologica Scandinavica, 1990, Vol.69 (1), p.79-86 |
| issn | 0001-6349 1600-0412 |
| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Adult Biological and medical sciences Contraception Behavior Cross-Sectional Studies Denmark Female Female genital diseases Greenland Gynecology. Andrology. Obstetrics Herpes Genitalis - complications Humans Medical sciences Non tumoral diseases Papanicolaou Test Papillomaviridae Risk Factors Sexual Behavior Smoking Tumor Virus Infections - complications Uterine Cervical Dysplasia - diagnosis Uterine Cervical Dysplasia - etiology Uterine Cervical Neoplasms - etiology Vaginal Smears |
| title | Abnormal Papanicolaou Smear: A Population-based Study of Risk Factors in Greenlandic and Danish Women |
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