Steroidal and Nonsteroidal Sulfamates as Potent Inhibitors of Steroid Sulfatase

Synthetic routes to potent steroidal and nonsteroidal sulfamate-based active site-directed inhibitors of the enzyme steroid sulfatase, a topical target in the treatment of postmenopausal women with hormone-dependent breast cancer, are described. Novel compounds were examined for estrone sulfatase (E...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of medicinal chemistry 1998-03, Vol.41 (7), p.1068-1083
Hauptverfasser:	Woo, L. W. Lawrence, Howarth, Nicola M, Purohit, Atul, Hejaz, Hatem A. M, Reed, Michael J, Potter, Barry V. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Arylsulfatases - antagonists & inhibitors Arylsulfatases - drug effects Biological and medical sciences Coumarins - chemical synthesis Coumarins - chemistry Coumarins - pharmacology Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Female General aspects Humans Medical sciences Naphthalenes - chemical synthesis Naphthalenes - pharmacology Pharmacology. Drug treatments Steryl-Sulfatase Sulfatases - antagonists & inhibitors Sulfatases - drug effects Sulfonamides - chemical synthesis Sulfonamides - chemistry Sulfonamides - pharmacology Tumor Cells, Cultured - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!