Determination of fenbendazole, praziquantel and pyrantel pamoate in dog plasma by high-performance liquid chromatography
Simple and rapid high-performance liquid chromatographic methods were developed for the determination of fenbendazole, praziquantel and pyrantel pamoate in dog plasma. The combination of these drugs is the most powerful treatment against most types of worms. Blood plasma samples obtained in a pharma...
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| Veröffentlicht in: | Journal of Chromatography A 1998-02, Vol.797 (1-2), p.237-244 |
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| container_title | Journal of Chromatography A |
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| creator | Morovján, György Csokán, Peter Makranszki, László Abdellah-Nagy, Edit Ait Tóth, Klára |
| description | Simple and rapid high-performance liquid chromatographic methods were developed for the determination of fenbendazole, praziquantel and pyrantel pamoate in dog plasma. The combination of these drugs is the most powerful treatment against most types of worms. Blood plasma samples obtained in a pharmacokinetic trial were prepared using solid-phase extraction. Fenbendazole and praziquantel were analyzed simultaneously by reversed-phase high-performance liquid chromatography on an octadecyl-modified silica stationary phase employing acetonitrile–phosphate buffer (pH 3.0) eluent and ultraviolet detection at 220 nm. Pyrantel was analyzed separately on a base-deactivated reversed-phase column using methanol–tetrahydrofuran–ammonium acetate buffer (pH 4.6) eluent and ultraviolet detection at 317 nm. Average recoveries for fenbendazole, praziquantel and pyrantel pamoate were 76.8, 93.4 and 90.5%, respectively. Limits of quantitation were in the range of 15–25 ng/ml plasma. |
| doi_str_mv | 10.1016/S0021-9673(97)01195-3 |
| format | Article |
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The combination of these drugs is the most powerful treatment against most types of worms. Blood plasma samples obtained in a pharmacokinetic trial were prepared using solid-phase extraction. Fenbendazole and praziquantel were analyzed simultaneously by reversed-phase high-performance liquid chromatography on an octadecyl-modified silica stationary phase employing acetonitrile–phosphate buffer (pH 3.0) eluent and ultraviolet detection at 220 nm. Pyrantel was analyzed separately on a base-deactivated reversed-phase column using methanol–tetrahydrofuran–ammonium acetate buffer (pH 4.6) eluent and ultraviolet detection at 317 nm. Average recoveries for fenbendazole, praziquantel and pyrantel pamoate were 76.8, 93.4 and 90.5%, respectively. Limits of quantitation were in the range of 15–25 ng/ml plasma.</description><identifier>ISSN: 0021-9673</identifier><identifier>DOI: 10.1016/S0021-9673(97)01195-3</identifier><identifier>PMID: 9542116</identifier><identifier>CODEN: JOCRAM</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Analysis ; Animals ; Anthelmintics - blood ; Biological and medical sciences ; Chromatography, High Pressure Liquid ; Dogs ; Female ; Fenbendazole ; Fenbendazole - blood ; General pharmacology ; Indicators and Reagents ; Male ; Medical sciences ; Pharmacology. Drug treatments ; Praziquantel ; Praziquantel - blood ; Pyrantel pamoate ; Pyrantel Pamoate - blood ; Spectrophotometry, Ultraviolet</subject><ispartof>Journal of Chromatography A, 1998-02, Vol.797 (1-2), p.237-244</ispartof><rights>1998 Elsevier Science B.V.</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-9f857ccc94d2009a898dbfd1b87b5bc808d574ee6ff9d3ed7d3f1a85c50ab003</citedby><cites>FETCH-LOGICAL-c455t-9f857ccc94d2009a898dbfd1b87b5bc808d574ee6ff9d3ed7d3f1a85c50ab003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0021-9673(97)01195-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,777,781,786,787,3538,23912,23913,25122,27906,27907,45977</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2221800$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9542116$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Morovján, György</creatorcontrib><creatorcontrib>Csokán, Peter</creatorcontrib><creatorcontrib>Makranszki, László</creatorcontrib><creatorcontrib>Abdellah-Nagy, Edit Ait</creatorcontrib><creatorcontrib>Tóth, Klára</creatorcontrib><title>Determination of fenbendazole, praziquantel and pyrantel pamoate in dog plasma by high-performance liquid chromatography</title><title>Journal of Chromatography A</title><addtitle>J Chromatogr A</addtitle><description>Simple and rapid high-performance liquid chromatographic methods were developed for the determination of fenbendazole, praziquantel and pyrantel pamoate in dog plasma. The combination of these drugs is the most powerful treatment against most types of worms. Blood plasma samples obtained in a pharmacokinetic trial were prepared using solid-phase extraction. Fenbendazole and praziquantel were analyzed simultaneously by reversed-phase high-performance liquid chromatography on an octadecyl-modified silica stationary phase employing acetonitrile–phosphate buffer (pH 3.0) eluent and ultraviolet detection at 220 nm. Pyrantel was analyzed separately on a base-deactivated reversed-phase column using methanol–tetrahydrofuran–ammonium acetate buffer (pH 4.6) eluent and ultraviolet detection at 317 nm. Average recoveries for fenbendazole, praziquantel and pyrantel pamoate were 76.8, 93.4 and 90.5%, respectively. Limits of quantitation were in the range of 15–25 ng/ml plasma.</description><subject>Analysis</subject><subject>Animals</subject><subject>Anthelmintics - blood</subject><subject>Biological and medical sciences</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Dogs</subject><subject>Female</subject><subject>Fenbendazole</subject><subject>Fenbendazole - blood</subject><subject>General pharmacology</subject><subject>Indicators and Reagents</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Praziquantel</subject><subject>Praziquantel - blood</subject><subject>Pyrantel pamoate</subject><subject>Pyrantel Pamoate - blood</subject><subject>Spectrophotometry, Ultraviolet</subject><issn>0021-9673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1r3DAQhnVoSDdpf8KCDqUkEDeSvbKsUyn5aAuBHJq7GEujXRVb8kreks2vr_eDveY0zMz7vjM8hMw5-8YZr2__MFbyQtWyulLymnGuRFF9ILPT-CO5yPkvY1wyWZ6TcyUWJef1jLze44ip9wFGHwONjjoMLQYLb7HDGzokePPrDYQROwrB0mGbDs0AfYQRqQ_UxiUdOsg90HZLV365KgZMLqYegkHaTQHeUrNKsYcxLhMMq-0ncuagy_j5WC_Jy-PDy92v4un55--7H0-FWQgxFso1Qhpj1MKWjCloVGNbZ3nbyFa0pmGNFXKBWDunbIVW2spxaIQRDFrGqkvy9RA7pLjeYB5177PBroOAcZO1VFLxmqtJKA5Ck2LOCZ0eku8hbTVnegdZ7yHrHU2tpN5D1tXkmx8PbNoe7cl1JDztvxz3kA10bqJnfD7JyrLkzf7P7wcZTiz-eUw6G48TPesTmlHb6N955D-qB547</recordid><startdate>19980227</startdate><enddate>19980227</enddate><creator>Morovján, György</creator><creator>Csokán, Peter</creator><creator>Makranszki, László</creator><creator>Abdellah-Nagy, Edit Ait</creator><creator>Tóth, Klára</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980227</creationdate><title>Determination of fenbendazole, praziquantel and pyrantel pamoate in dog plasma by high-performance liquid chromatography</title><author>Morovján, György ; Csokán, Peter ; Makranszki, László ; Abdellah-Nagy, Edit Ait ; Tóth, Klára</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-9f857ccc94d2009a898dbfd1b87b5bc808d574ee6ff9d3ed7d3f1a85c50ab003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Analysis</topic><topic>Animals</topic><topic>Anthelmintics - blood</topic><topic>Biological and medical sciences</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Dogs</topic><topic>Female</topic><topic>Fenbendazole</topic><topic>Fenbendazole - blood</topic><topic>General pharmacology</topic><topic>Indicators and Reagents</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Praziquantel</topic><topic>Praziquantel - blood</topic><topic>Pyrantel pamoate</topic><topic>Pyrantel Pamoate - blood</topic><topic>Spectrophotometry, Ultraviolet</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Morovján, György</creatorcontrib><creatorcontrib>Csokán, Peter</creatorcontrib><creatorcontrib>Makranszki, László</creatorcontrib><creatorcontrib>Abdellah-Nagy, Edit Ait</creatorcontrib><creatorcontrib>Tóth, Klára</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Chromatography A</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Morovján, György</au><au>Csokán, Peter</au><au>Makranszki, László</au><au>Abdellah-Nagy, Edit Ait</au><au>Tóth, Klára</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determination of fenbendazole, praziquantel and pyrantel pamoate in dog plasma by high-performance liquid chromatography</atitle><jtitle>Journal of Chromatography A</jtitle><addtitle>J Chromatogr A</addtitle><date>1998-02-27</date><risdate>1998</risdate><volume>797</volume><issue>1-2</issue><spage>237</spage><epage>244</epage><pages>237-244</pages><issn>0021-9673</issn><coden>JOCRAM</coden><abstract>Simple and rapid high-performance liquid chromatographic methods were developed for the determination of fenbendazole, praziquantel and pyrantel pamoate in dog plasma. The combination of these drugs is the most powerful treatment against most types of worms. Blood plasma samples obtained in a pharmacokinetic trial were prepared using solid-phase extraction. Fenbendazole and praziquantel were analyzed simultaneously by reversed-phase high-performance liquid chromatography on an octadecyl-modified silica stationary phase employing acetonitrile–phosphate buffer (pH 3.0) eluent and ultraviolet detection at 220 nm. Pyrantel was analyzed separately on a base-deactivated reversed-phase column using methanol–tetrahydrofuran–ammonium acetate buffer (pH 4.6) eluent and ultraviolet detection at 317 nm. Average recoveries for fenbendazole, praziquantel and pyrantel pamoate were 76.8, 93.4 and 90.5%, respectively. Limits of quantitation were in the range of 15–25 ng/ml plasma.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>9542116</pmid><doi>10.1016/S0021-9673(97)01195-3</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Analysis Animals Anthelmintics - blood Biological and medical sciences Chromatography, High Pressure Liquid Dogs Female Fenbendazole Fenbendazole - blood General pharmacology Indicators and Reagents Male Medical sciences Pharmacology. Drug treatments Praziquantel Praziquantel - blood Pyrantel pamoate Pyrantel Pamoate - blood Spectrophotometry, Ultraviolet |
| title | Determination of fenbendazole, praziquantel and pyrantel pamoate in dog plasma by high-performance liquid chromatography |
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