Incorporation of inositol into the phosphoinositides of lymphoblastoid cell lines established from bipolar manic-depressive patients
Lymphoblastoid cell lines established from patients suffering from bipolar manic-depressive psychosis or from a control group have been used to study the metabolism of the polyphosphoinositides in these cells. Cells were incubated for up to 6 h in [3H]inositol and the extent of inositol incorporatio...
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| Veröffentlicht in: | Journal of affective disorders 1990-05, Vol.19 (1), p.1-8 |
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| container_title | Journal of affective disorders |
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| creator | Banks, R E Aiton, J F Cramb, G Naylor, G J |
| description | Lymphoblastoid cell lines established from patients suffering from bipolar manic-depressive psychosis or from a control group have been used to study the metabolism of the polyphosphoinositides in these cells. Cells were incubated for up to 6 h in [3H]inositol and the extent of inositol incorporation into the mono-, di- and triphosphoinositides was measured after extracting the water- and lipid-soluble inositol-containing pools. Although both the uptake of inositol and the 'free' intracellular inositol pool sizes were similar in the two cell groups, the incorporation of [3H]inositol into the phosphoinositides of the cells derived from bipolar manic-depressives was significantly less (by around 50-60%) than that which occurred in the control cells. |
| doi_str_mv | 10.1016/0165-0327(90)90002-P |
| format | Article |
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Cells were incubated for up to 6 h in [3H]inositol and the extent of inositol incorporation into the mono-, di- and triphosphoinositides was measured after extracting the water- and lipid-soluble inositol-containing pools. Although both the uptake of inositol and the 'free' intracellular inositol pool sizes were similar in the two cell groups, the incorporation of [3H]inositol into the phosphoinositides of the cells derived from bipolar manic-depressives was significantly less (by around 50-60%) than that which occurred in the control cells.</description><identifier>ISSN: 0165-0327</identifier><identifier>DOI: 10.1016/0165-0327(90)90002-P</identifier><identifier>PMID: 2161438</identifier><language>eng</language><publisher>Netherlands</publisher><subject>Bipolar Disorder - genetics ; Bipolar Disorder - metabolism ; Cell Line ; Female ; Humans ; Inositol - metabolism ; Lymphocytes - metabolism ; Male ; Middle Aged ; Phosphatidylinositols - metabolism ; Risk Factors</subject><ispartof>Journal of affective disorders, 1990-05, Vol.19 (1), p.1-8</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c302t-2af3b2809d3c38ea02bf4a6db93df14ee0ef63ee359d812fd038cf5c10f578c23</citedby><cites>FETCH-LOGICAL-c302t-2af3b2809d3c38ea02bf4a6db93df14ee0ef63ee359d812fd038cf5c10f578c23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2161438$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Banks, R E</creatorcontrib><creatorcontrib>Aiton, J F</creatorcontrib><creatorcontrib>Cramb, G</creatorcontrib><creatorcontrib>Naylor, G J</creatorcontrib><title>Incorporation of inositol into the phosphoinositides of lymphoblastoid cell lines established from bipolar manic-depressive patients</title><title>Journal of affective disorders</title><addtitle>J Affect Disord</addtitle><description>Lymphoblastoid cell lines established from patients suffering from bipolar manic-depressive psychosis or from a control group have been used to study the metabolism of the polyphosphoinositides in these cells. Cells were incubated for up to 6 h in [3H]inositol and the extent of inositol incorporation into the mono-, di- and triphosphoinositides was measured after extracting the water- and lipid-soluble inositol-containing pools. Although both the uptake of inositol and the 'free' intracellular inositol pool sizes were similar in the two cell groups, the incorporation of [3H]inositol into the phosphoinositides of the cells derived from bipolar manic-depressives was significantly less (by around 50-60%) than that which occurred in the control cells.</description><subject>Bipolar Disorder - genetics</subject><subject>Bipolar Disorder - metabolism</subject><subject>Cell Line</subject><subject>Female</subject><subject>Humans</subject><subject>Inositol - metabolism</subject><subject>Lymphocytes - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Phosphatidylinositols - metabolism</subject><subject>Risk Factors</subject><issn>0165-0327</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kElLBDEQhXNQXEb_gUJOoofWLL3lKIPLgKAHPYd0UmEi6U6b9Aje_eGmnWEORcKrV6-KD6ELSm4pofVdrqognDXXgtwIQggr3g7QyV4-RqcpfWa9Fg05QkeM1rTk7Qn6XQ06xDFENbkw4GCxG0JyU_D5MwU8rQGP65BybRvOQJpt_qfPWudVmoIzWIP32LshNyFNqvMurcFgG0OPOzcGryLu1eB0YWCMkJL7zsF5KQxTOkOHVvkE57t3gT4eH96Xz8XL69Nqef9SaE7YVDBlecdaIgzXvAVFWGdLVZtOcGNpCUDA1hyAV8K0lFlDeKttpSmxVdNqxhfoaps7xvC1yXfK3qX5cjVA2CTZiEbQqpyN5daoY0gpgpVjdL2KP5ISOQOXM1k5k5WCyH_g8i2PXe7yN10PZj-0o83_AIp6go4</recordid><startdate>19900501</startdate><enddate>19900501</enddate><creator>Banks, R E</creator><creator>Aiton, J F</creator><creator>Cramb, G</creator><creator>Naylor, G J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19900501</creationdate><title>Incorporation of inositol into the phosphoinositides of lymphoblastoid cell lines established from bipolar manic-depressive patients</title><author>Banks, R E ; Aiton, J F ; Cramb, G ; Naylor, G J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c302t-2af3b2809d3c38ea02bf4a6db93df14ee0ef63ee359d812fd038cf5c10f578c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Bipolar Disorder - genetics</topic><topic>Bipolar Disorder - metabolism</topic><topic>Cell Line</topic><topic>Female</topic><topic>Humans</topic><topic>Inositol - metabolism</topic><topic>Lymphocytes - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Phosphatidylinositols - metabolism</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Banks, R E</creatorcontrib><creatorcontrib>Aiton, J F</creatorcontrib><creatorcontrib>Cramb, G</creatorcontrib><creatorcontrib>Naylor, G J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of affective disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Banks, R E</au><au>Aiton, J F</au><au>Cramb, G</au><au>Naylor, G J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incorporation of inositol into the phosphoinositides of lymphoblastoid cell lines established from bipolar manic-depressive patients</atitle><jtitle>Journal of affective disorders</jtitle><addtitle>J Affect Disord</addtitle><date>1990-05-01</date><risdate>1990</risdate><volume>19</volume><issue>1</issue><spage>1</spage><epage>8</epage><pages>1-8</pages><issn>0165-0327</issn><abstract>Lymphoblastoid cell lines established from patients suffering from bipolar manic-depressive psychosis or from a control group have been used to study the metabolism of the polyphosphoinositides in these cells. Cells were incubated for up to 6 h in [3H]inositol and the extent of inositol incorporation into the mono-, di- and triphosphoinositides was measured after extracting the water- and lipid-soluble inositol-containing pools. Although both the uptake of inositol and the 'free' intracellular inositol pool sizes were similar in the two cell groups, the incorporation of [3H]inositol into the phosphoinositides of the cells derived from bipolar manic-depressives was significantly less (by around 50-60%) than that which occurred in the control cells.</abstract><cop>Netherlands</cop><pmid>2161438</pmid><doi>10.1016/0165-0327(90)90002-P</doi><tpages>8</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Bipolar Disorder - genetics Bipolar Disorder - metabolism Cell Line Female Humans Inositol - metabolism Lymphocytes - metabolism Male Middle Aged Phosphatidylinositols - metabolism Risk Factors |
| title | Incorporation of inositol into the phosphoinositides of lymphoblastoid cell lines established from bipolar manic-depressive patients |
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