Ceramide‐independent CD28 and TCR signaling but reduced IL‐2 secretion in T cells of acid sphingomyelinase‐deficient mice

Ceramide generated by lysosomal acid sphingomyelinase (aSMase) has been proposed to contribute to CD28 co‐stimulatory signaling pathways. We used an aSMase‐deficient mouse line ( asmase − / − ) to elucidate the role of the aSMase in splenocytes stimulated with either a combination of anti‐CD3 and an...

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Veröffentlicht in:	European journal of immunology 1998-03, Vol.28 (3), p.874-880
Hauptverfasser:	Stoffel, Boris, Bauer, Petra, Nix, Michael, Deres, Karl, Stoffel, Wilhelm
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid sphingomyelinase‐deficient mouse Animals CD28 Antigens - physiology Cells, Cultured Ceramides - physiology Concanavalin A IL‐2 Interleukin-2 - metabolism Lymphocyte Activation Lysosomes - enzymology Mice Mice, Inbred C57BL Mice, Mutant Strains Receptors, Antigen, T-Cell - physiology Receptors, Interleukin-2 - metabolism Signal Transduction Sphingomyelin Phosphodiesterase - deficiency Spleen - cytology Staphylococcal enterotoxin B Superantigen T cell T-Lymphocytes - immunology
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