Otitis media with effusion and chronic upper respiratory tract infection in children: A randomized, placebo-controlled clinical study
This study was performed to investigate the course of spontaneous recovery from otitis media with effusion in children with chronic rhinosinusitis treated in various ways. One hundred forty‐one children between 3 and 10 years of age were selected for the presence of chronic rhino‐sinusitis and unila...
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| Veröffentlicht in: | The Laryngoscope 1990-06, Vol.100 (6), p.627-633 |
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| creator | Otten, Floris W. A. Grote, Jan J. |
| description | This study was performed to investigate the course of spontaneous recovery from otitis media with effusion in children with chronic rhinosinusitis treated in various ways. One hundred forty‐one children between 3 and 10 years of age were selected for the presence of chronic rhino‐sinusitis and unilateral or bilateral otitis media with effusion.
The children were assigned at random to one of four treatment groups, i.e., placebo, amoxicillin combined with xylometazoline hydrochloride nose drops, maxillary sinus drainage, or a combination of the latter two forms of therapy. The follow‐up period was 6 months. Drainage of the maxillary sinus had no effect on either the recovery of the chronic upper respiratory tract infection or otitis media with effusion. Amoxicillin combined with xylometazoline nose drops had no significant effect on recovery from the upper respiratory tract infection, but did have a small but significant effect on recovery from otitis media with effusion. However, the general tendency of the upper respiratory tract and ears to recover was poor. Persistence of the chronic upper respiratory tract infection during the follow‐up period proved to be a negative prognostic factor with respect to cure of otitis media with effusion.
Children with chronic rhinosinusitis as defined in this study appear to have a high risk of developing chronic otitis media with effusion. The results of the study are discussed. |
| doi_str_mv | 10.1288/00005537-199006000-00014 |
| format | Article |
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The children were assigned at random to one of four treatment groups, i.e., placebo, amoxicillin combined with xylometazoline hydrochloride nose drops, maxillary sinus drainage, or a combination of the latter two forms of therapy. The follow‐up period was 6 months. Drainage of the maxillary sinus had no effect on either the recovery of the chronic upper respiratory tract infection or otitis media with effusion. Amoxicillin combined with xylometazoline nose drops had no significant effect on recovery from the upper respiratory tract infection, but did have a small but significant effect on recovery from otitis media with effusion. However, the general tendency of the upper respiratory tract and ears to recover was poor. Persistence of the chronic upper respiratory tract infection during the follow‐up period proved to be a negative prognostic factor with respect to cure of otitis media with effusion.
Children with chronic rhinosinusitis as defined in this study appear to have a high risk of developing chronic otitis media with effusion. The results of the study are discussed.</description><identifier>ISSN: 0023-852X</identifier><identifier>EISSN: 1531-4995</identifier><identifier>DOI: 10.1288/00005537-199006000-00014</identifier><identifier>PMID: 1693411</identifier><identifier>CODEN: LARYA8</identifier><language>eng</language><publisher>Hoboken, NJ: John Wiley & Sons, Inc</publisher><subject>Amoxicillin - therapeutic use ; Biological and medical sciences ; Child ; Child, Preschool ; Chronic Disease ; Combined Modality Therapy ; Drainage ; Ent. Stomatology ; Female ; Humans ; Imidazoles - therapeutic use ; Male ; Medical sciences ; Nasal Decongestants - therapeutic use ; Otitis Media with Effusion - complications ; Otitis Media with Effusion - therapy ; Pharmacology. Drug treatments ; Prospective Studies ; Random Allocation ; Rhinitis - complications ; Rhinitis - drug therapy ; Rhinitis - therapy ; Sinusitis - complications ; Sinusitis - drug therapy ; Sinusitis - therapy</subject><ispartof>The Laryngoscope, 1990-06, Vol.100 (6), p.627-633</ispartof><rights>Copyright © 1990 The Triological Society</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4394-f79da40a8574bccf7c0ae1829f9338c5dc177bfad3e675dbb56bae376a731e383</citedby><cites>FETCH-LOGICAL-c4394-f79da40a8574bccf7c0ae1829f9338c5dc177bfad3e675dbb56bae376a731e383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19837523$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1693411$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Otten, Floris W. A.</creatorcontrib><creatorcontrib>Grote, Jan J.</creatorcontrib><title>Otitis media with effusion and chronic upper respiratory tract infection in children: A randomized, placebo-controlled clinical study</title><title>The Laryngoscope</title><addtitle>The Laryngoscope</addtitle><description>This study was performed to investigate the course of spontaneous recovery from otitis media with effusion in children with chronic rhinosinusitis treated in various ways. One hundred forty‐one children between 3 and 10 years of age were selected for the presence of chronic rhino‐sinusitis and unilateral or bilateral otitis media with effusion.
The children were assigned at random to one of four treatment groups, i.e., placebo, amoxicillin combined with xylometazoline hydrochloride nose drops, maxillary sinus drainage, or a combination of the latter two forms of therapy. The follow‐up period was 6 months. Drainage of the maxillary sinus had no effect on either the recovery of the chronic upper respiratory tract infection or otitis media with effusion. Amoxicillin combined with xylometazoline nose drops had no significant effect on recovery from the upper respiratory tract infection, but did have a small but significant effect on recovery from otitis media with effusion. However, the general tendency of the upper respiratory tract and ears to recover was poor. Persistence of the chronic upper respiratory tract infection during the follow‐up period proved to be a negative prognostic factor with respect to cure of otitis media with effusion.
Children with chronic rhinosinusitis as defined in this study appear to have a high risk of developing chronic otitis media with effusion. The results of the study are discussed.</description><subject>Amoxicillin - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Chronic Disease</subject><subject>Combined Modality Therapy</subject><subject>Drainage</subject><subject>Ent. Stomatology</subject><subject>Female</subject><subject>Humans</subject><subject>Imidazoles - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nasal Decongestants - therapeutic use</subject><subject>Otitis Media with Effusion - complications</subject><subject>Otitis Media with Effusion - therapy</subject><subject>Pharmacology. Drug treatments</subject><subject>Prospective Studies</subject><subject>Random Allocation</subject><subject>Rhinitis - complications</subject><subject>Rhinitis - drug therapy</subject><subject>Rhinitis - therapy</subject><subject>Sinusitis - complications</subject><subject>Sinusitis - drug therapy</subject><subject>Sinusitis - therapy</subject><issn>0023-852X</issn><issn>1531-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkV9vFCEUxYnR1LX6EUx40SdHYRiGwbdN1VWzsfFfrE-EYS4pyg5TYFLXd7-3tLO2r5IQcnN_91xyDkKYkue07roXpBzOmaiolIS0parKpc0dtKKc0aqRkt9FK0JqVnW8PruPHqT0oxCCcXKEjmgrWUPpCv05zS67hHcwOI0vXT7HYO2cXBixHgdszmMYncHzNEHEEdLkos4h7nGO2mTsRgsmX9FuLLDzQ4TxJV7jWKbDzv2G4RmevDbQh8qEMcfgPRRd74qs9jjledg_RPes9gkeHd5j9PXN6y8nb6vt6ebdyXpbmYbJprJCDrohuuOi6Y2xwhANtKullYx1hg-GCtFbPTBoBR_6nre9BiZaLRgF1rFj9HTRnWK4mCFltXPJgPd6hDAnJaSQRBJewG4BTQwpRbBqim6n415Roq4SUP8SUDcJqOsEyujjw465L67eDi6Wl_6TQ1-nYoAtRhmXbjHZMcFrVrhXC3fpPOz_e7_arj9957yhpWqvv1MtMi5l-HUjo-NP1YqySX37sFF1_XnzcXPWqffsLyNNsvM</recordid><startdate>199006</startdate><enddate>199006</enddate><creator>Otten, Floris W. A.</creator><creator>Grote, Jan J.</creator><general>John Wiley & Sons, Inc</general><general>Wiley-Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>199006</creationdate><title>Otitis media with effusion and chronic upper respiratory tract infection in children: A randomized, placebo-controlled clinical study</title><author>Otten, Floris W. A. ; Grote, Jan J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4394-f79da40a8574bccf7c0ae1829f9338c5dc177bfad3e675dbb56bae376a731e383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Amoxicillin - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Chronic Disease</topic><topic>Combined Modality Therapy</topic><topic>Drainage</topic><topic>Ent. Stomatology</topic><topic>Female</topic><topic>Humans</topic><topic>Imidazoles - therapeutic use</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nasal Decongestants - therapeutic use</topic><topic>Otitis Media with Effusion - complications</topic><topic>Otitis Media with Effusion - therapy</topic><topic>Pharmacology. Drug treatments</topic><topic>Prospective Studies</topic><topic>Random Allocation</topic><topic>Rhinitis - complications</topic><topic>Rhinitis - drug therapy</topic><topic>Rhinitis - therapy</topic><topic>Sinusitis - complications</topic><topic>Sinusitis - drug therapy</topic><topic>Sinusitis - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Otten, Floris W. A.</creatorcontrib><creatorcontrib>Grote, Jan J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>The Laryngoscope</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Otten, Floris W. A.</au><au>Grote, Jan J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Otitis media with effusion and chronic upper respiratory tract infection in children: A randomized, placebo-controlled clinical study</atitle><jtitle>The Laryngoscope</jtitle><addtitle>The Laryngoscope</addtitle><date>1990-06</date><risdate>1990</risdate><volume>100</volume><issue>6</issue><spage>627</spage><epage>633</epage><pages>627-633</pages><issn>0023-852X</issn><eissn>1531-4995</eissn><coden>LARYA8</coden><abstract>This study was performed to investigate the course of spontaneous recovery from otitis media with effusion in children with chronic rhinosinusitis treated in various ways. One hundred forty‐one children between 3 and 10 years of age were selected for the presence of chronic rhino‐sinusitis and unilateral or bilateral otitis media with effusion.
The children were assigned at random to one of four treatment groups, i.e., placebo, amoxicillin combined with xylometazoline hydrochloride nose drops, maxillary sinus drainage, or a combination of the latter two forms of therapy. The follow‐up period was 6 months. Drainage of the maxillary sinus had no effect on either the recovery of the chronic upper respiratory tract infection or otitis media with effusion. Amoxicillin combined with xylometazoline nose drops had no significant effect on recovery from the upper respiratory tract infection, but did have a small but significant effect on recovery from otitis media with effusion. However, the general tendency of the upper respiratory tract and ears to recover was poor. Persistence of the chronic upper respiratory tract infection during the follow‐up period proved to be a negative prognostic factor with respect to cure of otitis media with effusion.
Children with chronic rhinosinusitis as defined in this study appear to have a high risk of developing chronic otitis media with effusion. The results of the study are discussed.</abstract><cop>Hoboken, NJ</cop><pub>John Wiley & Sons, Inc</pub><pmid>1693411</pmid><doi>10.1288/00005537-199006000-00014</doi><tpages>7</tpages></addata></record> |
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| ispartof | The Laryngoscope, 1990-06, Vol.100 (6), p.627-633 |
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| language | eng |
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| subjects | Amoxicillin - therapeutic use Biological and medical sciences Child Child, Preschool Chronic Disease Combined Modality Therapy Drainage Ent. Stomatology Female Humans Imidazoles - therapeutic use Male Medical sciences Nasal Decongestants - therapeutic use Otitis Media with Effusion - complications Otitis Media with Effusion - therapy Pharmacology. Drug treatments Prospective Studies Random Allocation Rhinitis - complications Rhinitis - drug therapy Rhinitis - therapy Sinusitis - complications Sinusitis - drug therapy Sinusitis - therapy |
| title | Otitis media with effusion and chronic upper respiratory tract infection in children: A randomized, placebo-controlled clinical study |
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