Novel Synthetic Inhibitors of Selectin-Mediated Cell Adhesion:  Synthesis of 1,6-Bis[3-(3-carboxymethylphenyl)-4-(2-α-d-mannopyranosyloxy)phenyl]hexane (TBC1269)

Reports of a high-affinity ligand for E-selectin, sialyl di-Lewisx (sLexLex, 1), motivated us to incorporate modifications to previously reported biphenyl-based inhibitors that would provide additional interactions with the protein. These compounds were assayed for the ability to inhibit the binding...

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