Inhibition of GPI phospholipase C from Trypanosoma brucei by fluoro-inositol dodecylphosphonates

Glycosyl phosphatidylinositol phospholipase C (GPI-PLC) of Trypanosoma brucei is inhibited by myo-inositol(Ins)-1-O-dodecylphosphonate (VP-602L). Several novel fluoro-substituted analogs of 2-deoxy-myo-Ins-1-O-dedecylphosphonate, among which 2-deoxy-2-fluoro-scyllo-Ins-1-O-dodecylphosphonate (VP-616...

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Veröffentlicht in:	Biochemical and biophysical research communications 1998-03, Vol.244 (3), p.873-876
Hauptverfasser:	Morris, J.C, Ping-Sheng, L, Zhai, H.X, Shen, T.Y, Mesna-Wilmot, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dose-Response Relationship, Drug ESTERASAS ESTERASE ESTERASES Fluorine GLYCOSYL PHOSPHATIDYLINOSITOL Glycosylphosphatidylinositol Diacylglycerol-Lyase INHIBICION INHIBITION Inositol - analogs & derivatives Inositol - pharmacology Models, Chemical Organophosphonates - pharmacology Organophosphorus Compounds - pharmacology Phosphatidylinositol Diacylglycerol-Lyase Structure-Activity Relationship TRYPANOSOMA BRUCEI Trypanosoma brucei brucei - enzymology Type C Phospholipases - antagonists & inhibitors Type C Phospholipases - metabolism
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