Effect of Pharmacokinetic Sampling Methods on Aminoglycoside Dosing in Critically Ill Surgery Patients

We compared pharmacokinetic parameters derived from three aminoglycoside serum concentration sampling methods and evaluated their effects on recommended aminoglycoside dosing regimens in 60 critically ill surgery patients. Patients had presumed or documented gram‐negative sepsis, and had at least 4...

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Veröffentlicht in:	Pharmacotherapy 1998-03, Vol.18 (2), p.371-378
Hauptverfasser:	Mann, Henry J., Wittbrodt, Eric T., Baghaie, Ali A., Cerra, Frank B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Analysis of Variance Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - blood Anti-Bacterial Agents - pharmacokinetics Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Blood Specimen Collection - methods Critical Illness - therapy Cross Infection - microbiology Data Interpretation, Statistical Dose-Response Relationship, Drug Female Gentamicins - administration & dosage Gentamicins - blood Gentamicins - pharmacokinetics Humans Male Medical sciences Metabolic Clearance Rate Middle Aged Pharmacology. Drug treatments Postoperative Complications - blood Postoperative Complications - microbiology Postoperative Complications - surgery Reference Values Sample Size Surgical Wound Infection - blood Surgical Wound Infection - microbiology Time Factors Tobramycin - administration & dosage Tobramycin - blood Tobramycin - pharmacokinetics
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