Selective reduction of 6‐O‐sulfation in heparan sulfate from transformed mammary epithelial cells

Heparan sulfate at cell surfaces and in the extracellular matrix regulates cell proliferation and adhesion by binding to growth factors and matrix proteins via structurally specific oligosaccharide domains. We have used the hormonally regulated mouse mammary carcinoma cell line S115 as a model to el...

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