The Surgical Management of Recurrent Squamous Cell Carcinoma of the Vulva
Thirty-four patients with recurrent/persistent squamous cell carcinoma of the vulva were treated at the University of Michigan Medical Center from 1975-1988. At follow-up, 19 patients (56%) were free of disease and 15 were dead of disease. Three patients developed a “bridge” recurrence, one patient...
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| Veröffentlicht in: | Obstetrics and gynecology (New York. 1953) 1990-06, Vol.75 (6), p.1001-1005 |
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| container_title | Obstetrics and gynecology (New York. 1953) |
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| creator | HOPKINS, MICHAEL P REID, GARY C MORLEY, GEORGE W |
| description | Thirty-four patients with recurrent/persistent squamous cell carcinoma of the vulva were treated at the University of Michigan Medical Center from 1975-1988. At follow-up, 19 patients (56%) were free of disease and 15 were dead of disease. Three patients developed a “bridge” recurrence, one patient each with original stages I, II, and IV. Two of these patients were free of disease and one patient died of disease. Ten patients had metastatic disease to the groin lymph nodes at the time of recurrence, and all of these patients are dead of disease. Therapy for the recurrence consisted of five radical vulvectomies (80% survival), four pelvic exenterations (25% survival), and 25 wide radical excisions (56% survival). The lymph node status was highly significant in predicting outcome, with zero of ten patients remaining free of disease when the lymph nodes were involved and 19 of 24 free of disease when the lymph nodes were uninvolved (P |
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At follow-up, 19 patients (56%) were free of disease and 15 were dead of disease. Three patients developed a “bridge” recurrence, one patient each with original stages I, II, and IV. Two of these patients were free of disease and one patient died of disease. Ten patients had metastatic disease to the groin lymph nodes at the time of recurrence, and all of these patients are dead of disease. Therapy for the recurrence consisted of five radical vulvectomies (80% survival), four pelvic exenterations (25% survival), and 25 wide radical excisions (56% survival). The lymph node status was highly significant in predicting outcome, with zero of ten patients remaining free of disease when the lymph nodes were involved and 19 of 24 free of disease when the lymph nodes were uninvolved (P<.0001). Factors that did not influence survival included the institution where the initial surgery was performed and the interval from initial therapy to recurrence. Twenty patients received their initial therapy at the University of Michigan and 12 (60%) were free of disease. Fourteen patients were referred from outside institutions for their recurrence and seven (50%) were free of disease. Nineteen patients had a recurrence within 2 years and nine were free of disease, ten patients recurred between 2-10 years of whom seven were free of disease, and five patients recurred after 10 years with three free of disease. Radical excision of localized recurrent vulvar cancer provides acceptable survival results when the regional lymph nodes are not involved.</description><identifier>ISSN: 0029-7844</identifier><identifier>EISSN: 1873-233X</identifier><identifier>PMID: 2342725</identifier><identifier>CODEN: OBGNAS</identifier><language>eng</language><publisher>New York, NY: The American College of Obstetricians and Gynecologists</publisher><subject>Biological and medical sciences ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - surgery ; Female ; Female genital diseases ; Gynecology. Andrology. Obstetrics ; Humans ; Lymphatic Metastasis ; Medical sciences ; Neoplasm Recurrence, Local - surgery ; Survival Rate ; Tumors ; Vulvar Neoplasms - mortality ; Vulvar Neoplasms - pathology ; Vulvar Neoplasms - surgery</subject><ispartof>Obstetrics and gynecology (New York. 1953), 1990-06, Vol.75 (6), p.1001-1005</ispartof><rights>1990 The American College of Obstetricians and Gynecologists</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6950519$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2342725$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HOPKINS, MICHAEL P</creatorcontrib><creatorcontrib>REID, GARY C</creatorcontrib><creatorcontrib>MORLEY, GEORGE W</creatorcontrib><title>The Surgical Management of Recurrent Squamous Cell Carcinoma of the Vulva</title><title>Obstetrics and gynecology (New York. 1953)</title><addtitle>Obstet Gynecol</addtitle><description>Thirty-four patients with recurrent/persistent squamous cell carcinoma of the vulva were treated at the University of Michigan Medical Center from 1975-1988. At follow-up, 19 patients (56%) were free of disease and 15 were dead of disease. Three patients developed a “bridge” recurrence, one patient each with original stages I, II, and IV. Two of these patients were free of disease and one patient died of disease. Ten patients had metastatic disease to the groin lymph nodes at the time of recurrence, and all of these patients are dead of disease. Therapy for the recurrence consisted of five radical vulvectomies (80% survival), four pelvic exenterations (25% survival), and 25 wide radical excisions (56% survival). The lymph node status was highly significant in predicting outcome, with zero of ten patients remaining free of disease when the lymph nodes were involved and 19 of 24 free of disease when the lymph nodes were uninvolved (P<.0001). Factors that did not influence survival included the institution where the initial surgery was performed and the interval from initial therapy to recurrence. Twenty patients received their initial therapy at the University of Michigan and 12 (60%) were free of disease. Fourteen patients were referred from outside institutions for their recurrence and seven (50%) were free of disease. Nineteen patients had a recurrence within 2 years and nine were free of disease, ten patients recurred between 2-10 years of whom seven were free of disease, and five patients recurred after 10 years with three free of disease. Radical excision of localized recurrent vulvar cancer provides acceptable survival results when the regional lymph nodes are not involved.</description><subject>Biological and medical sciences</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Lymphatic Metastasis</subject><subject>Medical sciences</subject><subject>Neoplasm Recurrence, Local - surgery</subject><subject>Survival Rate</subject><subject>Tumors</subject><subject>Vulvar Neoplasms - mortality</subject><subject>Vulvar Neoplasms - pathology</subject><subject>Vulvar Neoplasms - surgery</subject><issn>0029-7844</issn><issn>1873-233X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kNtKw0AQhoMotR4eQciFeBfYU_ZwKcVDoSLYKt6FyWbTRjdJu5u1-PZuafBimPmZb4aZ_ySZYiloRij9PE2mCBGVCcnYeXLh_RdCCHNFJ8mEUEYEyafJfLUx6TK4daPBpi_Qwdq0phvSvk7fjA7OHcRyF6Dtg09nxtp0Bk43Xd_CARri_EewP3CVnNVgvbke82Xy_viwmj1ni9en-ex-kW2JRDSDEjOdK1FqqQjknCjGgdQEYVNXIBAmZUWYZEhTZRDiwPMKNOK4krRmBtHL5O64d-v6XTB-KNrG63gXdCaeWAglpJBYRPBmBEPZmqrYuqYF91uMv8f-7dgHH5-vHXS68f8YVznKsYoYO2L73g7G-W8b9sYVGwN22BTRUsRJjjKsVKyiymJE-_8Ay2NxXw</recordid><startdate>199006</startdate><enddate>199006</enddate><creator>HOPKINS, MICHAEL P</creator><creator>REID, GARY C</creator><creator>MORLEY, GEORGE W</creator><general>The American College of Obstetricians and Gynecologists</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199006</creationdate><title>The Surgical Management of Recurrent Squamous Cell Carcinoma of the Vulva</title><author>HOPKINS, MICHAEL P ; REID, GARY C ; MORLEY, GEORGE W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p2803-ab14c597bc892a562946a2f201efda7012bd24840c39e006a65dac061d83f4e03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Biological and medical sciences</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Lymphatic Metastasis</topic><topic>Medical sciences</topic><topic>Neoplasm Recurrence, Local - surgery</topic><topic>Survival Rate</topic><topic>Tumors</topic><topic>Vulvar Neoplasms - mortality</topic><topic>Vulvar Neoplasms - pathology</topic><topic>Vulvar Neoplasms - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HOPKINS, MICHAEL P</creatorcontrib><creatorcontrib>REID, GARY C</creatorcontrib><creatorcontrib>MORLEY, GEORGE W</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HOPKINS, MICHAEL P</au><au>REID, GARY C</au><au>MORLEY, GEORGE W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Surgical Management of Recurrent Squamous Cell Carcinoma of the Vulva</atitle><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle><addtitle>Obstet Gynecol</addtitle><date>1990-06</date><risdate>1990</risdate><volume>75</volume><issue>6</issue><spage>1001</spage><epage>1005</epage><pages>1001-1005</pages><issn>0029-7844</issn><eissn>1873-233X</eissn><coden>OBGNAS</coden><abstract>Thirty-four patients with recurrent/persistent squamous cell carcinoma of the vulva were treated at the University of Michigan Medical Center from 1975-1988. At follow-up, 19 patients (56%) were free of disease and 15 were dead of disease. Three patients developed a “bridge” recurrence, one patient each with original stages I, II, and IV. Two of these patients were free of disease and one patient died of disease. Ten patients had metastatic disease to the groin lymph nodes at the time of recurrence, and all of these patients are dead of disease. Therapy for the recurrence consisted of five radical vulvectomies (80% survival), four pelvic exenterations (25% survival), and 25 wide radical excisions (56% survival). The lymph node status was highly significant in predicting outcome, with zero of ten patients remaining free of disease when the lymph nodes were involved and 19 of 24 free of disease when the lymph nodes were uninvolved (P<.0001). Factors that did not influence survival included the institution where the initial surgery was performed and the interval from initial therapy to recurrence. Twenty patients received their initial therapy at the University of Michigan and 12 (60%) were free of disease. Fourteen patients were referred from outside institutions for their recurrence and seven (50%) were free of disease. Nineteen patients had a recurrence within 2 years and nine were free of disease, ten patients recurred between 2-10 years of whom seven were free of disease, and five patients recurred after 10 years with three free of disease. Radical excision of localized recurrent vulvar cancer provides acceptable survival results when the regional lymph nodes are not involved.</abstract><cop>New York, NY</cop><pub>The American College of Obstetricians and Gynecologists</pub><pmid>2342725</pmid><tpages>5</tpages></addata></record> |
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| ispartof | Obstetrics and gynecology (New York. 1953), 1990-06, Vol.75 (6), p.1001-1005 |
| issn | 0029-7844 1873-233X |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Biological and medical sciences Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - surgery Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Lymphatic Metastasis Medical sciences Neoplasm Recurrence, Local - surgery Survival Rate Tumors Vulvar Neoplasms - mortality Vulvar Neoplasms - pathology Vulvar Neoplasms - surgery |
| title | The Surgical Management of Recurrent Squamous Cell Carcinoma of the Vulva |
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