Nitric Oxide Mediates Interleukin-1-Induced Gene Expression of Matrix Metalloproteinases and Basic Fibroblast Growth Factor in Cultured Rabbit Articular Chondrocytes

We recently reported that nitric oxide (NO), which is produced by chondrocytes treated with interleukin-1β (IL-1), releases basic fibroblast growth factor (bFGF) stored in the matrix of articular chondrocytes. To clarify the mechanism of the IL-1-induced bFGF release, we investigated the production...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of biochemistry (Tokyo) 1998-03, Vol.123 (3), p.431-439
Hauptverfasser:	Sasaki, Kazuhiro, Hattori, Takako, Fujisawa, Takuo, Takahashi, Kojiro, Inoue, Hajime, Takigawa, Masaharu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals basic fibroblast growth factor Cartilage, Articular - cytology Cells, Cultured chondrocytes Chondrocytes - cytology Chondrocytes - drug effects Chondrocytes - metabolism Collagenases - drug effects Collagenases - genetics Collagenases - metabolism Fibroblast Growth Factor 2 - drug effects Fibroblast Growth Factor 2 - genetics Fibroblast Growth Factor 2 - pharmacology Gelatinases - drug effects Gelatinases - genetics Gelatinases - metabolism Gene Expression Regulation - drug effects Interleukin-1 - pharmacology interleukin-1β Male matrix metalloproteinase Matrix Metalloproteinase 2 Matrix Metalloproteinase 3 - drug effects Matrix Metalloproteinase 3 - genetics Matrix Metalloproteinase 3 - metabolism Matrix Metalloproteinase 9 Matrix Metalloproteinases, Membrane-Associated Membrane Glycoproteins - drug effects Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Metalloendopeptidases - antagonists & inhibitors Metalloendopeptidases - drug effects Metalloendopeptidases - genetics Metalloendopeptidases - metabolism nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase - drug effects Nitric Oxide Synthase - genetics Nitric Oxide Synthase - metabolism Nitric Oxide Synthase Type II omega-N-Methylarginine - pharmacology Protease Inhibitors - pharmacology Proteoglycans - drug effects Proteoglycans - genetics Proteoglycans - metabolism Rabbits Syndecan-3
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!