Ca2+-Independent Activation of the Endothelial Nitric Oxide Synthase in Response to Tyrosine Phosphatase Inhibitors and Fluid Shear Stress

Fluid shear stress enhances NO formation via a Ca () tyrosine kinase inhibitor-sensitive pathway. In the present study, we investigated the effects of the protein tyrosine phosphatase inhibitor phenylarsine oxide and of fluid shear stress on endothelial NO production as well as on the membrane assoc...

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Veröffentlicht in:	Circulation research 1998-04, Vol.82 (6), p.686-695
Hauptverfasser:	Fleming, Ingrid, Bauersachs, Johann, Fisslthaler, Beate, Busse, Rudi
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Arsenicals - pharmacology Biological and medical sciences Blood vessels and receptors Calcium - metabolism Calmodulin - antagonists & inhibitors Carotid Arteries - drug effects Carotid Arteries - physiology Egtazic Acid - analogs & derivatives Egtazic Acid - pharmacology Endothelium, Vascular - drug effects Endothelium, Vascular - enzymology Endothelium, Vascular - physiology Enzyme Activation Enzyme Inhibitors - pharmacology Female Fundamental and applied biological sciences. Psychology Imidazoles - pharmacology In Vitro Techniques Male Muscle Relaxation - drug effects Nitric Oxide - physiology Nitric Oxide Synthase - metabolism Phosphorylation Protein Tyrosine Phosphatases - antagonists & inhibitors Protein-Tyrosine Kinases - metabolism Rabbits Stress, Mechanical Vasodilation Vertebrates: cardiovascular system
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