Meiotic induction in cumulus cell-enclosed mouse oocytes: involvement of the pentose phosphate pathway

In this study we tested the hypothesis that the pentose phosphate pathway (PPP) participates in the meiotic induction of mouse oocytes. The electron acceptors methylene blue, phenazine ethosulfate (PES), and pyrroline-5-carboxylate (P5C) oxidize NADPH to NADP and activate the NADP-dependent enzymes...

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Veröffentlicht in:	Biology of reproduction 1998-04, Vol.58 (4), p.1084-1094
Hauptverfasser:	DOWNS, S. M, HUMPHERSON, P. G, LEESE, H. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Deoxyglucose - pharmacology Enzyme Inhibitors - pharmacology Female Follicle Stimulating Hormone - pharmacology Fundamental and applied biological sciences. Psychology Glucosephosphate Dehydrogenase - antagonists & inhibitors Glucosephosphate Dehydrogenase - metabolism Mammalian female genital system Meiosis Methylene Blue - pharmacology Mice Mice, Inbred C57BL Morphology. Physiology NADP - metabolism NADPH Oxidases - antagonists & inhibitors Oocytes - cytology Ovarian Follicle - physiology Oxidation-Reduction Pentose Phosphate Pathway - physiology Phenazines - pharmacology Phosphogluconate Dehydrogenase - antagonists & inhibitors Phosphogluconate Dehydrogenase - metabolism Pyrroles - pharmacology Vertebrates: reproduction
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