Novel role of human CD4 molecule identified in neurodegeneration
The human CD4 molecule (hCD4) is expressed on T lymphocytes and macrophages and acts as a key component of the cellular receptor for HIV. At baseline, hCD4 transgenic mice expressed hCD4 on microglia, the resident mononuclear phagocytes of the brain, and showed no neuronal damage. Activation of brai...
Gespeichert in:
| Veröffentlicht in: | Nature medicine 1998-04, Vol.4 (4), p.441-446 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 446 |
|---|---|
| container_issue | 4 |
| container_start_page | 441 |
| container_title | Nature medicine |
| container_volume | 4 |
| creator | Buttini, Manuel Westland, Christopher E. Masliah, Eliezer Yafeh, Arie M. Wyss-Coray, Tony Mucke, Lennart |
| description | The human CD4 molecule (hCD4) is expressed on T lymphocytes and macrophages and acts as a key component of the cellular receptor for HIV. At baseline, hCD4 transgenic mice expressed hCD4 on microglia, the resident mononuclear phagocytes of the brain, and showed no neuronal damage. Activation of brain microglia by peripheral immune challenges elicited neurodegeneration in hCD4 mice but not in nontransgenic controls. In post-mortem brain tissues from AIDS patients with opportunistic infections, but without typical HIV encephalitis, hCD4 expression correlated with neurodegeneration. We conclude that hCD4 may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. |
| doi_str_mv | 10.1038/nm0498-441 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79786246</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>16518016</sourcerecordid><originalsourceid>FETCH-LOGICAL-c349t-4b713a1a9ade7aa9cfbc0d5cd0452077092cbd503a2b8fd7f8002a4dc18fb9393</originalsourceid><addsrcrecordid>eNqFkEtLxDAUhYMoo45u3AtduVCqN23aJDtlfMKgGwV3Ic1j7NAmY9IK_nszzOBKcHUv53ycxYfQCYZLDCW7cj0QznJC8A46wBWpc0zhfTf9QFnOeFXvo8MYlwBQQsUnaMITRDkcoOtn_2W6LPjOZN5mH2MvXTa7JVmfEjWmtNXGDa1tjc5alzkzBq_NwjgT5NB6d4T2rOyiOd7eKXq7v3udPebzl4en2c08VyXhQ04aikuJJZfaUCm5so0CXSkNpCqAUuCFanQFpSwaZjW1DKCQRCvMbMNLXk7R2WZ3FfznaOIg-jYq03XSGT9GQTlldUHqf0FcV5gBXoPnG1AFH2MwVqxC28vwLTCItVex8SqS1wSfblfHpjf6F92KTP3Fpo-pcQsTxNKPwSUjf639AD7qgNc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16518016</pqid></control><display><type>article</type><title>Novel role of human CD4 molecule identified in neurodegeneration</title><source>MEDLINE</source><source>Nature</source><source>Springer Nature - Complete Springer Journals</source><creator>Buttini, Manuel ; Westland, Christopher E. ; Masliah, Eliezer ; Yafeh, Arie M. ; Wyss-Coray, Tony ; Mucke, Lennart</creator><creatorcontrib>Buttini, Manuel ; Westland, Christopher E. ; Masliah, Eliezer ; Yafeh, Arie M. ; Wyss-Coray, Tony ; Mucke, Lennart</creatorcontrib><description>The human CD4 molecule (hCD4) is expressed on T lymphocytes and macrophages and acts as a key component of the cellular receptor for HIV. At baseline, hCD4 transgenic mice expressed hCD4 on microglia, the resident mononuclear phagocytes of the brain, and showed no neuronal damage. Activation of brain microglia by peripheral immune challenges elicited neurodegeneration in hCD4 mice but not in nontransgenic controls. In post-mortem brain tissues from AIDS patients with opportunistic infections, but without typical HIV encephalitis, hCD4 expression correlated with neurodegeneration. We conclude that hCD4 may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system.</description><identifier>ISSN: 1078-8956</identifier><identifier>EISSN: 1546-170X</identifier><identifier>DOI: 10.1038/nm0498-441</identifier><identifier>PMID: 9546790</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>AIDS-Related Opportunistic Infections - immunology ; AIDS-Related Opportunistic Infections - pathology ; AIDS/HIV ; Animals ; Antigens, CD - biosynthesis ; Antigens, CD - genetics ; Antigens, CD - physiology ; Biomedical and Life Sciences ; Biomedicine ; Brain - immunology ; Brain - pathology ; Cancer Research ; CD4 Antigens - biosynthesis ; CD4 Antigens - genetics ; CD4 Antigens - physiology ; Heterozygote ; Homozygote ; Humans ; Infectious Diseases ; Inflammation ; Metabolic Diseases ; Mice ; Mice, Inbred C57BL ; Mice, Inbred Strains ; Mice, Transgenic ; Microglia - immunology ; Microglia - pathology ; Molecular Medicine ; Neocortex - immunology ; Neocortex - pathology ; Nerve Degeneration - immunology ; Nerve Degeneration - pathology ; Neurosciences ; Synapses - pathology</subject><ispartof>Nature medicine, 1998-04, Vol.4 (4), p.441-446</ispartof><rights>Springer Nature America, Inc. 1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c349t-4b713a1a9ade7aa9cfbc0d5cd0452077092cbd503a2b8fd7f8002a4dc18fb9393</citedby><cites>FETCH-LOGICAL-c349t-4b713a1a9ade7aa9cfbc0d5cd0452077092cbd503a2b8fd7f8002a4dc18fb9393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/nm0498-441$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/nm0498-441$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9546790$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Buttini, Manuel</creatorcontrib><creatorcontrib>Westland, Christopher E.</creatorcontrib><creatorcontrib>Masliah, Eliezer</creatorcontrib><creatorcontrib>Yafeh, Arie M.</creatorcontrib><creatorcontrib>Wyss-Coray, Tony</creatorcontrib><creatorcontrib>Mucke, Lennart</creatorcontrib><title>Novel role of human CD4 molecule identified in neurodegeneration</title><title>Nature medicine</title><addtitle>Nat Med</addtitle><addtitle>Nat Med</addtitle><description>The human CD4 molecule (hCD4) is expressed on T lymphocytes and macrophages and acts as a key component of the cellular receptor for HIV. At baseline, hCD4 transgenic mice expressed hCD4 on microglia, the resident mononuclear phagocytes of the brain, and showed no neuronal damage. Activation of brain microglia by peripheral immune challenges elicited neurodegeneration in hCD4 mice but not in nontransgenic controls. In post-mortem brain tissues from AIDS patients with opportunistic infections, but without typical HIV encephalitis, hCD4 expression correlated with neurodegeneration. We conclude that hCD4 may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system.</description><subject>AIDS-Related Opportunistic Infections - immunology</subject><subject>AIDS-Related Opportunistic Infections - pathology</subject><subject>AIDS/HIV</subject><subject>Animals</subject><subject>Antigens, CD - biosynthesis</subject><subject>Antigens, CD - genetics</subject><subject>Antigens, CD - physiology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain - immunology</subject><subject>Brain - pathology</subject><subject>Cancer Research</subject><subject>CD4 Antigens - biosynthesis</subject><subject>CD4 Antigens - genetics</subject><subject>CD4 Antigens - physiology</subject><subject>Heterozygote</subject><subject>Homozygote</subject><subject>Humans</subject><subject>Infectious Diseases</subject><subject>Inflammation</subject><subject>Metabolic Diseases</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Inbred Strains</subject><subject>Mice, Transgenic</subject><subject>Microglia - immunology</subject><subject>Microglia - pathology</subject><subject>Molecular Medicine</subject><subject>Neocortex - immunology</subject><subject>Neocortex - pathology</subject><subject>Nerve Degeneration - immunology</subject><subject>Nerve Degeneration - pathology</subject><subject>Neurosciences</subject><subject>Synapses - pathology</subject><issn>1078-8956</issn><issn>1546-170X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLxDAUhYMoo45u3AtduVCqN23aJDtlfMKgGwV3Ic1j7NAmY9IK_nszzOBKcHUv53ycxYfQCYZLDCW7cj0QznJC8A46wBWpc0zhfTf9QFnOeFXvo8MYlwBQQsUnaMITRDkcoOtn_2W6LPjOZN5mH2MvXTa7JVmfEjWmtNXGDa1tjc5alzkzBq_NwjgT5NB6d4T2rOyiOd7eKXq7v3udPebzl4en2c08VyXhQ04aikuJJZfaUCm5so0CXSkNpCqAUuCFanQFpSwaZjW1DKCQRCvMbMNLXk7R2WZ3FfznaOIg-jYq03XSGT9GQTlldUHqf0FcV5gBXoPnG1AFH2MwVqxC28vwLTCItVex8SqS1wSfblfHpjf6F92KTP3Fpo-pcQsTxNKPwSUjf639AD7qgNc</recordid><startdate>19980401</startdate><enddate>19980401</enddate><creator>Buttini, Manuel</creator><creator>Westland, Christopher E.</creator><creator>Masliah, Eliezer</creator><creator>Yafeh, Arie M.</creator><creator>Wyss-Coray, Tony</creator><creator>Mucke, Lennart</creator><general>Nature Publishing Group US</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19980401</creationdate><title>Novel role of human CD4 molecule identified in neurodegeneration</title><author>Buttini, Manuel ; Westland, Christopher E. ; Masliah, Eliezer ; Yafeh, Arie M. ; Wyss-Coray, Tony ; Mucke, Lennart</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c349t-4b713a1a9ade7aa9cfbc0d5cd0452077092cbd503a2b8fd7f8002a4dc18fb9393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>AIDS-Related Opportunistic Infections - immunology</topic><topic>AIDS-Related Opportunistic Infections - pathology</topic><topic>AIDS/HIV</topic><topic>Animals</topic><topic>Antigens, CD - biosynthesis</topic><topic>Antigens, CD - genetics</topic><topic>Antigens, CD - physiology</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain - immunology</topic><topic>Brain - pathology</topic><topic>Cancer Research</topic><topic>CD4 Antigens - biosynthesis</topic><topic>CD4 Antigens - genetics</topic><topic>CD4 Antigens - physiology</topic><topic>Heterozygote</topic><topic>Homozygote</topic><topic>Humans</topic><topic>Infectious Diseases</topic><topic>Inflammation</topic><topic>Metabolic Diseases</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Inbred Strains</topic><topic>Mice, Transgenic</topic><topic>Microglia - immunology</topic><topic>Microglia - pathology</topic><topic>Molecular Medicine</topic><topic>Neocortex - immunology</topic><topic>Neocortex - pathology</topic><topic>Nerve Degeneration - immunology</topic><topic>Nerve Degeneration - pathology</topic><topic>Neurosciences</topic><topic>Synapses - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Buttini, Manuel</creatorcontrib><creatorcontrib>Westland, Christopher E.</creatorcontrib><creatorcontrib>Masliah, Eliezer</creatorcontrib><creatorcontrib>Yafeh, Arie M.</creatorcontrib><creatorcontrib>Wyss-Coray, Tony</creatorcontrib><creatorcontrib>Mucke, Lennart</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nature medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Buttini, Manuel</au><au>Westland, Christopher E.</au><au>Masliah, Eliezer</au><au>Yafeh, Arie M.</au><au>Wyss-Coray, Tony</au><au>Mucke, Lennart</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel role of human CD4 molecule identified in neurodegeneration</atitle><jtitle>Nature medicine</jtitle><stitle>Nat Med</stitle><addtitle>Nat Med</addtitle><date>1998-04-01</date><risdate>1998</risdate><volume>4</volume><issue>4</issue><spage>441</spage><epage>446</epage><pages>441-446</pages><issn>1078-8956</issn><eissn>1546-170X</eissn><abstract>The human CD4 molecule (hCD4) is expressed on T lymphocytes and macrophages and acts as a key component of the cellular receptor for HIV. At baseline, hCD4 transgenic mice expressed hCD4 on microglia, the resident mononuclear phagocytes of the brain, and showed no neuronal damage. Activation of brain microglia by peripheral immune challenges elicited neurodegeneration in hCD4 mice but not in nontransgenic controls. In post-mortem brain tissues from AIDS patients with opportunistic infections, but without typical HIV encephalitis, hCD4 expression correlated with neurodegeneration. We conclude that hCD4 may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>9546790</pmid><doi>10.1038/nm0498-441</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1078-8956 |
| ispartof | Nature medicine, 1998-04, Vol.4 (4), p.441-446 |
| issn | 1078-8956 1546-170X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79786246 |
| source | MEDLINE; Nature; Springer Nature - Complete Springer Journals |
| subjects | AIDS-Related Opportunistic Infections - immunology AIDS-Related Opportunistic Infections - pathology AIDS/HIV Animals Antigens, CD - biosynthesis Antigens, CD - genetics Antigens, CD - physiology Biomedical and Life Sciences Biomedicine Brain - immunology Brain - pathology Cancer Research CD4 Antigens - biosynthesis CD4 Antigens - genetics CD4 Antigens - physiology Heterozygote Homozygote Humans Infectious Diseases Inflammation Metabolic Diseases Mice Mice, Inbred C57BL Mice, Inbred Strains Mice, Transgenic Microglia - immunology Microglia - pathology Molecular Medicine Neocortex - immunology Neocortex - pathology Nerve Degeneration - immunology Nerve Degeneration - pathology Neurosciences Synapses - pathology |
| title | Novel role of human CD4 molecule identified in neurodegeneration |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T19%3A49%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Novel%20role%20of%20human%20CD4%20molecule%20identified%20in%20neurodegeneration&rft.jtitle=Nature%20medicine&rft.au=Buttini,%20Manuel&rft.date=1998-04-01&rft.volume=4&rft.issue=4&rft.spage=441&rft.epage=446&rft.pages=441-446&rft.issn=1078-8956&rft.eissn=1546-170X&rft_id=info:doi/10.1038/nm0498-441&rft_dat=%3Cproquest_cross%3E16518016%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16518016&rft_id=info:pmid/9546790&rfr_iscdi=true |