Pharmacological Evaluation of Hydroxypropylcellulose-Ethylcellulose Microcapsules Containing Piretanide

Hydroxypropylcellulose (HPC)-ethylcellulose (EC) microcapsules containing piretanide prepared by a solvent evaporation technique, were evaluated on pharmacokinetic, pharmacodynamic and pharmacological parameters in spontaneously hypertensive rats (SHR). HPC-EC10 (5 : 3) microcapsules showed sustaine...

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Veröffentlicht in:	Journal of Pharmacobio-Dynamics 1990, Vol.13(1), pp.1-9
Hauptverfasser:	TSUJIYAMA, Tsuyoshi, SUZUKI, Nobuo, KURIKI, Takeo, KAWATA, Masakazu, GOTO, Shigeru
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Aldosterone - blood Animals Antihypertensive agents Biological and medical sciences Blood Pressure - drug effects Body Weight - drug effects Cardiovascular system Cellulose - analogs & derivatives Diuretics - administration & dosage Diuretics - blood Diuretics - pharmacokinetics Diuretics - pharmacology Drug Administration Schedule Drug Compounding Heart Rate - drug effects Hypertension - drug therapy Male Medical sciences Pharmacology. Drug treatments Rats Rats, Inbred SHR Renin - blood Sulfonamides - administration & dosage Sulfonamides - blood Sulfonamides - pharmacokinetics Sulfonamides - pharmacology sustained release
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