Local Treatment of Prosthetic Vascular Graft Infection with Multivesicular Liposome-Encapsulated Amikacin
Background.Contaminated surgical fields limit the use of prosthetic vascular grafts. We studied the efficacy of sustained-release amikacin applied locally to contaminated grafts in the prevention of infectious complications. Materials and methods.Thirty-one New Zealand white rabbits underwent placem...
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| Veröffentlicht in: | The Journal of surgical research 1998-01, Vol.74 (1), p.54-58 |
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| creator | Huh, Joseph Chen, John C. Furman, Grace M. Malki, Charles King, Bryan Kafie, Fernando Wilson, Samuel Eric |
| description | Background.Contaminated surgical fields limit the use of prosthetic vascular grafts. We studied the efficacy of sustained-release amikacin applied locally to contaminated grafts in the prevention of infectious complications.
Materials and methods.Thirty-one New Zealand white rabbits underwent placement of a polytetrafluoroethylene (PTFE) interposition graft in a 1-cm segment of the descending aorta. The surgical field was infected with application of 105to 108Staphylococcus aureusorganisms suspended in normal saline solution. Nineteen rabbits underwent contaminated aortic graft placement without treatment. Twelve rabbits were treated with local application of 2.5 ml of amikacin encapsulated in lipid particle-based sustained-release dosage form. Rabbits were observed for 2 weeks and then evaluated for the presence of graft infection.
Results.Seventy-five percent of the treated rabbits survived without evidence of graft infection or systemic sepsis versus 37% in the untreated group (P< 0.04). Cultures verified the absence of organisms in all surviving rabbits without clinical infection.
Conclusions.Sustained-release lipid particle-encapsulated amikacin applied to contaminated PTFE grafts increased survival and decreased postoperative graft infections. Adjunctive use of local, delayed-release antibiotics in contaminated vascular beds may allow wider clinical use of prosthetic grafts. |
| doi_str_mv | 10.1006/jsre.1997.5188 |
| format | Article |
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Materials and methods.Thirty-one New Zealand white rabbits underwent placement of a polytetrafluoroethylene (PTFE) interposition graft in a 1-cm segment of the descending aorta. The surgical field was infected with application of 105to 108Staphylococcus aureusorganisms suspended in normal saline solution. Nineteen rabbits underwent contaminated aortic graft placement without treatment. Twelve rabbits were treated with local application of 2.5 ml of amikacin encapsulated in lipid particle-based sustained-release dosage form. Rabbits were observed for 2 weeks and then evaluated for the presence of graft infection.
Results.Seventy-five percent of the treated rabbits survived without evidence of graft infection or systemic sepsis versus 37% in the untreated group (P< 0.04). Cultures verified the absence of organisms in all surviving rabbits without clinical infection.
Conclusions.Sustained-release lipid particle-encapsulated amikacin applied to contaminated PTFE grafts increased survival and decreased postoperative graft infections. Adjunctive use of local, delayed-release antibiotics in contaminated vascular beds may allow wider clinical use of prosthetic grafts.</description><identifier>ISSN: 0022-4804</identifier><identifier>EISSN: 1095-8673</identifier><identifier>DOI: 10.1006/jsre.1997.5188</identifier><identifier>PMID: 9536974</identifier><identifier>CODEN: JSGRA2</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Amikacin - administration & dosage ; Animals ; Aorta, Thoracic - surgery ; Biological and medical sciences ; Blood Vessel Prosthesis - adverse effects ; Cardiovascular system ; Delayed-Action Preparations ; Drug Delivery Systems ; liposome ; Liposomes ; local antibiotic ; Medical sciences ; Microscopy, Electron, Scanning ; Miscellaneous ; Particle Size ; Pharmacology. Drug treatments ; Polytetrafluoroethylene ; Prosthesis-Related Infections - drug therapy ; Prosthesis-Related Infections - prevention & control ; prosthetic grafts ; Rabbits ; Staphylococcal Infections - drug therapy ; Staphylococcal Infections - prevention & control</subject><ispartof>The Journal of surgical research, 1998-01, Vol.74 (1), p.54-58</ispartof><rights>1998 Academic Press</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-bb3c99f8a87829bed6c148ec3c941134e7753ab6ee491832279e7759f3b3d2a13</citedby><cites>FETCH-LOGICAL-c368t-bb3c99f8a87829bed6c148ec3c941134e7753ab6ee491832279e7759f3b3d2a13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S002248049795188X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,3537,4036,4037,23909,23910,25118,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2235615$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9536974$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huh, Joseph</creatorcontrib><creatorcontrib>Chen, John C.</creatorcontrib><creatorcontrib>Furman, Grace M.</creatorcontrib><creatorcontrib>Malki, Charles</creatorcontrib><creatorcontrib>King, Bryan</creatorcontrib><creatorcontrib>Kafie, Fernando</creatorcontrib><creatorcontrib>Wilson, Samuel Eric</creatorcontrib><title>Local Treatment of Prosthetic Vascular Graft Infection with Multivesicular Liposome-Encapsulated Amikacin</title><title>The Journal of surgical research</title><addtitle>J Surg Res</addtitle><description>Background.Contaminated surgical fields limit the use of prosthetic vascular grafts. We studied the efficacy of sustained-release amikacin applied locally to contaminated grafts in the prevention of infectious complications.
Materials and methods.Thirty-one New Zealand white rabbits underwent placement of a polytetrafluoroethylene (PTFE) interposition graft in a 1-cm segment of the descending aorta. The surgical field was infected with application of 105to 108Staphylococcus aureusorganisms suspended in normal saline solution. Nineteen rabbits underwent contaminated aortic graft placement without treatment. Twelve rabbits were treated with local application of 2.5 ml of amikacin encapsulated in lipid particle-based sustained-release dosage form. Rabbits were observed for 2 weeks and then evaluated for the presence of graft infection.
Results.Seventy-five percent of the treated rabbits survived without evidence of graft infection or systemic sepsis versus 37% in the untreated group (P< 0.04). Cultures verified the absence of organisms in all surviving rabbits without clinical infection.
Conclusions.Sustained-release lipid particle-encapsulated amikacin applied to contaminated PTFE grafts increased survival and decreased postoperative graft infections. Adjunctive use of local, delayed-release antibiotics in contaminated vascular beds may allow wider clinical use of prosthetic grafts.</description><subject>Amikacin - administration & dosage</subject><subject>Animals</subject><subject>Aorta, Thoracic - surgery</subject><subject>Biological and medical sciences</subject><subject>Blood Vessel Prosthesis - adverse effects</subject><subject>Cardiovascular system</subject><subject>Delayed-Action Preparations</subject><subject>Drug Delivery Systems</subject><subject>liposome</subject><subject>Liposomes</subject><subject>local antibiotic</subject><subject>Medical sciences</subject><subject>Microscopy, Electron, Scanning</subject><subject>Miscellaneous</subject><subject>Particle Size</subject><subject>Pharmacology. Drug treatments</subject><subject>Polytetrafluoroethylene</subject><subject>Prosthesis-Related Infections - drug therapy</subject><subject>Prosthesis-Related Infections - prevention & control</subject><subject>prosthetic grafts</subject><subject>Rabbits</subject><subject>Staphylococcal Infections - drug therapy</subject><subject>Staphylococcal Infections - prevention & control</subject><issn>0022-4804</issn><issn>1095-8673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEFPxCAQRonR6Lp69WbCwXjrCqUtcDRmXU3W6EG9EkqnEW3LClTjv5dmN948kfnmMZl5CJ1RsqCEVFfvwcOCSskXJRViD80okWUmKs720YyQPM8KQYojdBzCO0m15OwQHcqSVZIXM2TXzugOP3vQsYchYtfiJ-9CfINoDX7VwYyd9njldRvx_dCCidYN-NvGN_wwdtF-QbBbZm03LrgesuVg9CakLEKDr3v7oY0dTtBBq7sAp7t3jl5ul883d9n6cXV_c73ODKtEzOqaGSlboQUXuayhqQwtBJiUFpSyAjgvma4rgEJSwfKcyymSLatZk2vK5uhyO3fj3ecIIareBgNdpwdwY1BcckFKViRwsQVNujdZbNXG2177H0WJmtyqya2a3KrJbfpwvps81j00f_hOZupf7PrJmu5arwdjwx-W56ysaJkwscUgWfiy4FUwFgYDjfXJrmqc_W-DX9zHlsY</recordid><startdate>199801</startdate><enddate>199801</enddate><creator>Huh, Joseph</creator><creator>Chen, John C.</creator><creator>Furman, Grace M.</creator><creator>Malki, Charles</creator><creator>King, Bryan</creator><creator>Kafie, Fernando</creator><creator>Wilson, Samuel Eric</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199801</creationdate><title>Local Treatment of Prosthetic Vascular Graft Infection with Multivesicular Liposome-Encapsulated Amikacin</title><author>Huh, Joseph ; Chen, John C. ; Furman, Grace M. ; Malki, Charles ; King, Bryan ; Kafie, Fernando ; Wilson, Samuel Eric</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-bb3c99f8a87829bed6c148ec3c941134e7753ab6ee491832279e7759f3b3d2a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Amikacin - administration & dosage</topic><topic>Animals</topic><topic>Aorta, Thoracic - surgery</topic><topic>Biological and medical sciences</topic><topic>Blood Vessel Prosthesis - adverse effects</topic><topic>Cardiovascular system</topic><topic>Delayed-Action Preparations</topic><topic>Drug Delivery Systems</topic><topic>liposome</topic><topic>Liposomes</topic><topic>local antibiotic</topic><topic>Medical sciences</topic><topic>Microscopy, Electron, Scanning</topic><topic>Miscellaneous</topic><topic>Particle Size</topic><topic>Pharmacology. Drug treatments</topic><topic>Polytetrafluoroethylene</topic><topic>Prosthesis-Related Infections - drug therapy</topic><topic>Prosthesis-Related Infections - prevention & control</topic><topic>prosthetic grafts</topic><topic>Rabbits</topic><topic>Staphylococcal Infections - drug therapy</topic><topic>Staphylococcal Infections - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huh, Joseph</creatorcontrib><creatorcontrib>Chen, John C.</creatorcontrib><creatorcontrib>Furman, Grace M.</creatorcontrib><creatorcontrib>Malki, Charles</creatorcontrib><creatorcontrib>King, Bryan</creatorcontrib><creatorcontrib>Kafie, Fernando</creatorcontrib><creatorcontrib>Wilson, Samuel Eric</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of surgical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huh, Joseph</au><au>Chen, John C.</au><au>Furman, Grace M.</au><au>Malki, Charles</au><au>King, Bryan</au><au>Kafie, Fernando</au><au>Wilson, Samuel Eric</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Local Treatment of Prosthetic Vascular Graft Infection with Multivesicular Liposome-Encapsulated Amikacin</atitle><jtitle>The Journal of surgical research</jtitle><addtitle>J Surg Res</addtitle><date>1998-01</date><risdate>1998</risdate><volume>74</volume><issue>1</issue><spage>54</spage><epage>58</epage><pages>54-58</pages><issn>0022-4804</issn><eissn>1095-8673</eissn><coden>JSGRA2</coden><abstract>Background.Contaminated surgical fields limit the use of prosthetic vascular grafts. We studied the efficacy of sustained-release amikacin applied locally to contaminated grafts in the prevention of infectious complications.
Materials and methods.Thirty-one New Zealand white rabbits underwent placement of a polytetrafluoroethylene (PTFE) interposition graft in a 1-cm segment of the descending aorta. The surgical field was infected with application of 105to 108Staphylococcus aureusorganisms suspended in normal saline solution. Nineteen rabbits underwent contaminated aortic graft placement without treatment. Twelve rabbits were treated with local application of 2.5 ml of amikacin encapsulated in lipid particle-based sustained-release dosage form. Rabbits were observed for 2 weeks and then evaluated for the presence of graft infection.
Results.Seventy-five percent of the treated rabbits survived without evidence of graft infection or systemic sepsis versus 37% in the untreated group (P< 0.04). Cultures verified the absence of organisms in all surviving rabbits without clinical infection.
Conclusions.Sustained-release lipid particle-encapsulated amikacin applied to contaminated PTFE grafts increased survival and decreased postoperative graft infections. Adjunctive use of local, delayed-release antibiotics in contaminated vascular beds may allow wider clinical use of prosthetic grafts.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>9536974</pmid><doi>10.1006/jsre.1997.5188</doi><tpages>5</tpages></addata></record> |
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| subjects | Amikacin - administration & dosage Animals Aorta, Thoracic - surgery Biological and medical sciences Blood Vessel Prosthesis - adverse effects Cardiovascular system Delayed-Action Preparations Drug Delivery Systems liposome Liposomes local antibiotic Medical sciences Microscopy, Electron, Scanning Miscellaneous Particle Size Pharmacology. Drug treatments Polytetrafluoroethylene Prosthesis-Related Infections - drug therapy Prosthesis-Related Infections - prevention & control prosthetic grafts Rabbits Staphylococcal Infections - drug therapy Staphylococcal Infections - prevention & control |
| title | Local Treatment of Prosthetic Vascular Graft Infection with Multivesicular Liposome-Encapsulated Amikacin |
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