Black tea consumption does not protect low density lipoprotein from oxidative modification
To investigate the in vivo and in vitro effects of black tea on the oxidative modification of low density lipoprotein (LDL). The antioxidant activity of the tea was studied in vitro by measuring the resistance of the LDL to oxidative modification in the presence of copper. The effects of tea consump...
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| Veröffentlicht in: | European journal of clinical nutrition 1998-03, Vol.52 (3), p.202-206 |
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| creator | MCANLIS, G. T MCENENY, J PEARCE, J YOUNG, I. S |
| description | To investigate the in vivo and in vitro effects of black tea on the oxidative modification of low density lipoprotein (LDL).
The antioxidant activity of the tea was studied in vitro by measuring the resistance of the LDL to oxidative modification in the presence of copper. The effects of tea consumption in vivo were investigated in two settings. Firstly, to assess the acute effects of tea consumption, five fasting healthy subjects ingested 600 mls (50.7+/-5.4 mg flavonoids) of black tea and peripheral venous blood was collected at 0, 30, 60, 90, 120 and 180 min after consumption. Secondly, to assess the effects of chronic tea consumption, a randomised crossover trial of tea (126.8+/-13.5 mg flavonoids) and coffee consumption was carried out in ten healthy subjects.
Black tea extract increased the resistance of LDL in vitro in a concentration dependent manner. There was no significant change in total plasma antioxidant capacity or susceptibility of the LDL to oxidation over the 3 h period after consumption of black tea. The four-week crossover study in which coffee was used as a control against the black tea showed no significant difference in the total plasma antioxidant capacity or susceptibility of LDL to oxidation between the tea and coffee groups. Serum lipids, including total cholesterol, triglycerides, LDL cholesterol and HDL cholesterol did not change significantly throughout the study.
The consumption of moderate quantities of black tea acutely or for one week does not increase plasma total antioxidant capacity or alter the susceptibility of LDL to oxidation. |
| doi_str_mv | 10.1038/sj.ejcn.1600540 |
| format | Article |
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The antioxidant activity of the tea was studied in vitro by measuring the resistance of the LDL to oxidative modification in the presence of copper. The effects of tea consumption in vivo were investigated in two settings. Firstly, to assess the acute effects of tea consumption, five fasting healthy subjects ingested 600 mls (50.7+/-5.4 mg flavonoids) of black tea and peripheral venous blood was collected at 0, 30, 60, 90, 120 and 180 min after consumption. Secondly, to assess the effects of chronic tea consumption, a randomised crossover trial of tea (126.8+/-13.5 mg flavonoids) and coffee consumption was carried out in ten healthy subjects.
Black tea extract increased the resistance of LDL in vitro in a concentration dependent manner. There was no significant change in total plasma antioxidant capacity or susceptibility of the LDL to oxidation over the 3 h period after consumption of black tea. The four-week crossover study in which coffee was used as a control against the black tea showed no significant difference in the total plasma antioxidant capacity or susceptibility of LDL to oxidation between the tea and coffee groups. Serum lipids, including total cholesterol, triglycerides, LDL cholesterol and HDL cholesterol did not change significantly throughout the study.
The consumption of moderate quantities of black tea acutely or for one week does not increase plasma total antioxidant capacity or alter the susceptibility of LDL to oxidation.</description><identifier>ISSN: 0954-3007</identifier><identifier>EISSN: 1476-5640</identifier><identifier>DOI: 10.1038/sj.ejcn.1600540</identifier><identifier>PMID: 9537306</identifier><language>eng</language><publisher>Basingstoke: Nature Publishing</publisher><subject>Acute effects ; Adult ; Antioxidants ; Biological and medical sciences ; Black tea ; Cholesterol ; Chromatography, High Pressure Liquid ; Cocoa ; Coffee ; Consumption ; Cross-Over Studies ; Density ; Design modifications ; Diet ; Female ; Flavonoids ; High density lipoprotein ; Humans ; In vivo methods and tests ; Kinetics ; Lipids ; Lipids - blood ; Lipoproteins, LDL - blood ; Low density lipoprotein ; Male ; Medical sciences ; Miscellaneous ; Oxidation ; Oxidation resistance ; Oxidation-Reduction ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Serum lipids ; Tea ; Triglycerides</subject><ispartof>European journal of clinical nutrition, 1998-03, Vol.52 (3), p.202-206</ispartof><rights>1998 INIST-CNRS</rights><rights>Copyright Macmillan Journals Ltd. Mar 1998</rights><rights>Macmillan Publishers Limited 1998.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c376t-7ff3f43a7b9dc8d5cf96393b1668fc4c89930e499181cf792a315094ad5360123</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2174339$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9537306$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MCANLIS, G. T</creatorcontrib><creatorcontrib>MCENENY, J</creatorcontrib><creatorcontrib>PEARCE, J</creatorcontrib><creatorcontrib>YOUNG, I. S</creatorcontrib><title>Black tea consumption does not protect low density lipoprotein from oxidative modification</title><title>European journal of clinical nutrition</title><addtitle>Eur J Clin Nutr</addtitle><description>To investigate the in vivo and in vitro effects of black tea on the oxidative modification of low density lipoprotein (LDL).
The antioxidant activity of the tea was studied in vitro by measuring the resistance of the LDL to oxidative modification in the presence of copper. The effects of tea consumption in vivo were investigated in two settings. Firstly, to assess the acute effects of tea consumption, five fasting healthy subjects ingested 600 mls (50.7+/-5.4 mg flavonoids) of black tea and peripheral venous blood was collected at 0, 30, 60, 90, 120 and 180 min after consumption. Secondly, to assess the effects of chronic tea consumption, a randomised crossover trial of tea (126.8+/-13.5 mg flavonoids) and coffee consumption was carried out in ten healthy subjects.
Black tea extract increased the resistance of LDL in vitro in a concentration dependent manner. There was no significant change in total plasma antioxidant capacity or susceptibility of the LDL to oxidation over the 3 h period after consumption of black tea. The four-week crossover study in which coffee was used as a control against the black tea showed no significant difference in the total plasma antioxidant capacity or susceptibility of LDL to oxidation between the tea and coffee groups. Serum lipids, including total cholesterol, triglycerides, LDL cholesterol and HDL cholesterol did not change significantly throughout the study.
The consumption of moderate quantities of black tea acutely or for one week does not increase plasma total antioxidant capacity or alter the susceptibility of LDL to oxidation.</description><subject>Acute effects</subject><subject>Adult</subject><subject>Antioxidants</subject><subject>Biological and medical sciences</subject><subject>Black tea</subject><subject>Cholesterol</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Cocoa</subject><subject>Coffee</subject><subject>Consumption</subject><subject>Cross-Over Studies</subject><subject>Density</subject><subject>Design modifications</subject><subject>Diet</subject><subject>Female</subject><subject>Flavonoids</subject><subject>High density lipoprotein</subject><subject>Humans</subject><subject>In vivo methods and tests</subject><subject>Kinetics</subject><subject>Lipids</subject><subject>Lipids - blood</subject><subject>Lipoproteins, LDL - blood</subject><subject>Low density lipoprotein</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Oxidation</subject><subject>Oxidation resistance</subject><subject>Oxidation-Reduction</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Serum lipids</subject><subject>Tea</subject><subject>Triglycerides</subject><issn>0954-3007</issn><issn>1476-5640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc1v1DAQxS1U1G4LZ06VrFL1lu04_oqPpYKCVIkLXLhYXseWHBJ7iR3a_vd4adQDEqeR5v3mzWgeQu8IbAnQ7joPWzfYuCUCgDN4hTaESdFwweAIbUBx1lAAeYJOcx4AqijbY3SsOJUUxAb9-DAa-xMXZ7BNMS_TvoQUcZ9cxjEVvJ9TcbbgMT3g3sUcyhMewz797YeI_ZwmnB5Db0r47fCU-uCDNQeTN-i1N2N2b9d6hr5_-vjt9nNz__Xuy-3NfWOpFKWR3lPPqJE71duu59YrQRXdESE6b5ntlKLgmFKkI9ZL1RpKOChmek4FkJaeoatn33rTr8XloqeQrRtHE11aspZKdtASVcH3_4BDWuZYb9OtYK1oOQFeqYv_UkQJXndDha6fITunnGfn9X4Ok5mfNAF9CEbnQR-C0WswdeJ8tV12k-tf-DWJql-uusnWjH420Yb8grVEMlrf8gfDvZZO</recordid><startdate>19980301</startdate><enddate>19980301</enddate><creator>MCANLIS, G. T</creator><creator>MCENENY, J</creator><creator>PEARCE, J</creator><creator>YOUNG, I. S</creator><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>19980301</creationdate><title>Black tea consumption does not protect low density lipoprotein from oxidative modification</title><author>MCANLIS, G. T ; MCENENY, J ; PEARCE, J ; YOUNG, I. S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c376t-7ff3f43a7b9dc8d5cf96393b1668fc4c89930e499181cf792a315094ad5360123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Acute effects</topic><topic>Adult</topic><topic>Antioxidants</topic><topic>Biological and medical sciences</topic><topic>Black tea</topic><topic>Cholesterol</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Cocoa</topic><topic>Coffee</topic><topic>Consumption</topic><topic>Cross-Over Studies</topic><topic>Density</topic><topic>Design modifications</topic><topic>Diet</topic><topic>Female</topic><topic>Flavonoids</topic><topic>High density lipoprotein</topic><topic>Humans</topic><topic>In vivo methods and tests</topic><topic>Kinetics</topic><topic>Lipids</topic><topic>Lipids - blood</topic><topic>Lipoproteins, LDL - blood</topic><topic>Low density lipoprotein</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Oxidation</topic><topic>Oxidation resistance</topic><topic>Oxidation-Reduction</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Serum lipids</topic><topic>Tea</topic><topic>Triglycerides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MCANLIS, G. T</creatorcontrib><creatorcontrib>MCENENY, J</creatorcontrib><creatorcontrib>PEARCE, J</creatorcontrib><creatorcontrib>YOUNG, I. 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S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Black tea consumption does not protect low density lipoprotein from oxidative modification</atitle><jtitle>European journal of clinical nutrition</jtitle><addtitle>Eur J Clin Nutr</addtitle><date>1998-03-01</date><risdate>1998</risdate><volume>52</volume><issue>3</issue><spage>202</spage><epage>206</epage><pages>202-206</pages><issn>0954-3007</issn><eissn>1476-5640</eissn><abstract>To investigate the in vivo and in vitro effects of black tea on the oxidative modification of low density lipoprotein (LDL).
The antioxidant activity of the tea was studied in vitro by measuring the resistance of the LDL to oxidative modification in the presence of copper. The effects of tea consumption in vivo were investigated in two settings. Firstly, to assess the acute effects of tea consumption, five fasting healthy subjects ingested 600 mls (50.7+/-5.4 mg flavonoids) of black tea and peripheral venous blood was collected at 0, 30, 60, 90, 120 and 180 min after consumption. Secondly, to assess the effects of chronic tea consumption, a randomised crossover trial of tea (126.8+/-13.5 mg flavonoids) and coffee consumption was carried out in ten healthy subjects.
Black tea extract increased the resistance of LDL in vitro in a concentration dependent manner. There was no significant change in total plasma antioxidant capacity or susceptibility of the LDL to oxidation over the 3 h period after consumption of black tea. The four-week crossover study in which coffee was used as a control against the black tea showed no significant difference in the total plasma antioxidant capacity or susceptibility of LDL to oxidation between the tea and coffee groups. Serum lipids, including total cholesterol, triglycerides, LDL cholesterol and HDL cholesterol did not change significantly throughout the study.
The consumption of moderate quantities of black tea acutely or for one week does not increase plasma total antioxidant capacity or alter the susceptibility of LDL to oxidation.</abstract><cop>Basingstoke</cop><pub>Nature Publishing</pub><pmid>9537306</pmid><doi>10.1038/sj.ejcn.1600540</doi><tpages>5</tpages></addata></record> |
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| subjects | Acute effects Adult Antioxidants Biological and medical sciences Black tea Cholesterol Chromatography, High Pressure Liquid Cocoa Coffee Consumption Cross-Over Studies Density Design modifications Diet Female Flavonoids High density lipoprotein Humans In vivo methods and tests Kinetics Lipids Lipids - blood Lipoproteins, LDL - blood Low density lipoprotein Male Medical sciences Miscellaneous Oxidation Oxidation resistance Oxidation-Reduction Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Serum lipids Tea Triglycerides |
| title | Black tea consumption does not protect low density lipoprotein from oxidative modification |
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