Can grafting of an octapeptide improve the structure of a de novo protein?

Structural properties and conformational stability of de novo proteins – albebetin and albeferon (albebetin with a grafted interferon fragment) – were studied by means of CD spectroscopy, gel filtration and urea-induced unfolding. The results allow us to conclude that albebetin possesses the propert...

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Veröffentlicht in:	FEBS letters 1998-03, Vol.425 (1), p.101-104
Hauptverfasser:	Aphasizheva, Inna Yu, Dolgikh, Dmitry A, Abdullaev, Ziedulla K, Uversky, Vladimir N, Kirpichnikov, Mikhail P, Ptitsyn, Oleg B
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromatography, Gel Circular Dichroism Cloning, Molecular De novo protein Escherichia coli - genetics Interferon Molten globule Oligopeptides - chemistry Protein design Protein Engineering Protein expression Protein Folding Protein Structure, Secondary Protein Structure, Tertiary Proteins - chemistry Proteins - genetics Recombinant Proteins - chemistry Recombinant Proteins - genetics Thermodynamics Urea - chemistry
Online-Zugang:	Volltext
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