Treatment of Acute Superior Sagittal Sinus Thrombosis by t-PA Infusion via Venography—Direct Thrombolytic Therapy in the Acute Phase
Background Dural sinus thrombosis is a relatively rare syndrome, often with a very poor prognosis. Systemic anticoagulant therapy has produced poor results; therefore rapid recanalization of the affected vessels is essential. The recent advancements in angiographic technique and catheter technology...
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Veröffentlicht in: | Surgical neurology 1998-04, Vol.49 (4), p.425-429 |
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creator | Niwa, Jun Ohyama, Hiroshi Matumura, Shigeki Maeda, Yoshihiro Shimizu, Tadakazu |
description | Background
Dural sinus thrombosis is a relatively rare syndrome, often with a very poor prognosis. Systemic anticoagulant therapy has produced poor results; therefore rapid recanalization of the affected vessels is essential. The recent advancements in angiographic technique and catheter technology enable us to perform direct selective venography.
Case report
We observed a case of acute superior sagittal sinus thrombosis in a pregnant woman. The patient’s consciousness level and motor function gradually deteriorated. Direct thrombolysis was performed via venography.
Results
The patient was treated successfully by thrombolysis with infusion of t-PA via selective venography within 2 days of rapid clinical deterioration and sustained a dramatic improvement of her neurological deficits.
Conclusions
Direct thrombolysis via selective venography is considered a safe and useful treatment for dural sinus thrombosis in the acute phase. |
doi_str_mv | 10.1016/S0090-3019(97)00453-9 |
format | Article |
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Dural sinus thrombosis is a relatively rare syndrome, often with a very poor prognosis. Systemic anticoagulant therapy has produced poor results; therefore rapid recanalization of the affected vessels is essential. The recent advancements in angiographic technique and catheter technology enable us to perform direct selective venography.
Case report
We observed a case of acute superior sagittal sinus thrombosis in a pregnant woman. The patient’s consciousness level and motor function gradually deteriorated. Direct thrombolysis was performed via venography.
Results
The patient was treated successfully by thrombolysis with infusion of t-PA via selective venography within 2 days of rapid clinical deterioration and sustained a dramatic improvement of her neurological deficits.
Conclusions
Direct thrombolysis via selective venography is considered a safe and useful treatment for dural sinus thrombosis in the acute phase.</description><identifier>ISSN: 0090-3019</identifier><identifier>EISSN: 1879-3339</identifier><identifier>DOI: 10.1016/S0090-3019(97)00453-9</identifier><identifier>PMID: 9537662</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Acute Disease ; acute phase ; Adult ; Cranial Sinuses ; Female ; Humans ; Infusions, Intravenous ; Phlebography ; Plasminogen Activators - therapeutic use ; Pregnancy ; Pregnancy Complications, Cardiovascular - therapy ; Sinus Thrombosis, Intracranial - therapy ; superior sagittal sinus ; Thrombolysis ; Thrombolytic Therapy ; Tissue Plasminogen Activator - therapeutic use ; tissue-plasminogen activator ; Tomography, X-Ray Computed ; venography</subject><ispartof>Surgical neurology, 1998-04, Vol.49 (4), p.425-429</ispartof><rights>1998 Elsevier Science Inc.</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-caffab50f7f42ecef2ad6f0b0ed670f8578231cc8d261490b8d34ea3e689a4703</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9537662$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Niwa, Jun</creatorcontrib><creatorcontrib>Ohyama, Hiroshi</creatorcontrib><creatorcontrib>Matumura, Shigeki</creatorcontrib><creatorcontrib>Maeda, Yoshihiro</creatorcontrib><creatorcontrib>Shimizu, Tadakazu</creatorcontrib><title>Treatment of Acute Superior Sagittal Sinus Thrombosis by t-PA Infusion via Venography—Direct Thrombolytic Therapy in the Acute Phase</title><title>Surgical neurology</title><addtitle>Surg Neurol</addtitle><description>Background
Dural sinus thrombosis is a relatively rare syndrome, often with a very poor prognosis. Systemic anticoagulant therapy has produced poor results; therefore rapid recanalization of the affected vessels is essential. The recent advancements in angiographic technique and catheter technology enable us to perform direct selective venography.
Case report
We observed a case of acute superior sagittal sinus thrombosis in a pregnant woman. The patient’s consciousness level and motor function gradually deteriorated. Direct thrombolysis was performed via venography.
Results
The patient was treated successfully by thrombolysis with infusion of t-PA via selective venography within 2 days of rapid clinical deterioration and sustained a dramatic improvement of her neurological deficits.
Conclusions
Direct thrombolysis via selective venography is considered a safe and useful treatment for dural sinus thrombosis in the acute phase.</description><subject>Acute Disease</subject><subject>acute phase</subject><subject>Adult</subject><subject>Cranial Sinuses</subject><subject>Female</subject><subject>Humans</subject><subject>Infusions, Intravenous</subject><subject>Phlebography</subject><subject>Plasminogen Activators - therapeutic use</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Cardiovascular - therapy</subject><subject>Sinus Thrombosis, Intracranial - therapy</subject><subject>superior sagittal sinus</subject><subject>Thrombolysis</subject><subject>Thrombolytic Therapy</subject><subject>Tissue Plasminogen Activator - therapeutic use</subject><subject>tissue-plasminogen activator</subject><subject>Tomography, X-Ray Computed</subject><subject>venography</subject><issn>0090-3019</issn><issn>1879-3339</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFO3DAQhq2qiG5pHwHJJ9QeApM4ieNTtdrSFgkJpN32ajnOmDVK4q3tIOXGiSfgCXkSwu7CldNo9P___JqPkOMUTlNIy7MlgICEQSq-Cf4dIC9YIj6QWVpxkTDGxEcye7N8Ip9DuAUAJgpxSA5FwXhZZjPysPKoYod9pM7QuR4i0uWwQW-dp0t1Y2NULV3afgh0tfauq12wgdYjjcn1nF70ZgjW9fTOKvoPe3fj1WY9Pt0__rQedXzNtGO0elpwkkdqexrXuG-7XquAX8iBUW3Ar_t5RP7-Ol8t_iSXV78vFvPLRLMSYqKVMaouwHCTZ6jRZKopDdSATcnBVAWvMpZqXTVZmeYC6qphOSqGZSVUzoEdkZPd3Y13_wcMUXY2aGxb1aMbguSC84pBNRmLnVF7F4JHIzfedsqPMgX5wl9u-csXuFJwueUvxZQ73hcMdYfNW2oPfNJ_7HScvryz6GXQFnuNzZaXbJx9p-EZQYeYZw</recordid><startdate>19980401</startdate><enddate>19980401</enddate><creator>Niwa, Jun</creator><creator>Ohyama, Hiroshi</creator><creator>Matumura, Shigeki</creator><creator>Maeda, Yoshihiro</creator><creator>Shimizu, Tadakazu</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980401</creationdate><title>Treatment of Acute Superior Sagittal Sinus Thrombosis by t-PA Infusion via Venography—Direct Thrombolytic Therapy in the Acute Phase</title><author>Niwa, Jun ; Ohyama, Hiroshi ; Matumura, Shigeki ; Maeda, Yoshihiro ; Shimizu, Tadakazu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-caffab50f7f42ecef2ad6f0b0ed670f8578231cc8d261490b8d34ea3e689a4703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Acute Disease</topic><topic>acute phase</topic><topic>Adult</topic><topic>Cranial Sinuses</topic><topic>Female</topic><topic>Humans</topic><topic>Infusions, Intravenous</topic><topic>Phlebography</topic><topic>Plasminogen Activators - therapeutic use</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Cardiovascular - therapy</topic><topic>Sinus Thrombosis, Intracranial - therapy</topic><topic>superior sagittal sinus</topic><topic>Thrombolysis</topic><topic>Thrombolytic Therapy</topic><topic>Tissue Plasminogen Activator - therapeutic use</topic><topic>tissue-plasminogen activator</topic><topic>Tomography, X-Ray Computed</topic><topic>venography</topic><toplevel>online_resources</toplevel><creatorcontrib>Niwa, Jun</creatorcontrib><creatorcontrib>Ohyama, Hiroshi</creatorcontrib><creatorcontrib>Matumura, Shigeki</creatorcontrib><creatorcontrib>Maeda, Yoshihiro</creatorcontrib><creatorcontrib>Shimizu, Tadakazu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Surgical neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Niwa, Jun</au><au>Ohyama, Hiroshi</au><au>Matumura, Shigeki</au><au>Maeda, Yoshihiro</au><au>Shimizu, Tadakazu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment of Acute Superior Sagittal Sinus Thrombosis by t-PA Infusion via Venography—Direct Thrombolytic Therapy in the Acute Phase</atitle><jtitle>Surgical neurology</jtitle><addtitle>Surg Neurol</addtitle><date>1998-04-01</date><risdate>1998</risdate><volume>49</volume><issue>4</issue><spage>425</spage><epage>429</epage><pages>425-429</pages><issn>0090-3019</issn><eissn>1879-3339</eissn><abstract>Background
Dural sinus thrombosis is a relatively rare syndrome, often with a very poor prognosis. Systemic anticoagulant therapy has produced poor results; therefore rapid recanalization of the affected vessels is essential. The recent advancements in angiographic technique and catheter technology enable us to perform direct selective venography.
Case report
We observed a case of acute superior sagittal sinus thrombosis in a pregnant woman. The patient’s consciousness level and motor function gradually deteriorated. Direct thrombolysis was performed via venography.
Results
The patient was treated successfully by thrombolysis with infusion of t-PA via selective venography within 2 days of rapid clinical deterioration and sustained a dramatic improvement of her neurological deficits.
Conclusions
Direct thrombolysis via selective venography is considered a safe and useful treatment for dural sinus thrombosis in the acute phase.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>9537662</pmid><doi>10.1016/S0090-3019(97)00453-9</doi><tpages>5</tpages></addata></record> |
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subjects | Acute Disease acute phase Adult Cranial Sinuses Female Humans Infusions, Intravenous Phlebography Plasminogen Activators - therapeutic use Pregnancy Pregnancy Complications, Cardiovascular - therapy Sinus Thrombosis, Intracranial - therapy superior sagittal sinus Thrombolysis Thrombolytic Therapy Tissue Plasminogen Activator - therapeutic use tissue-plasminogen activator Tomography, X-Ray Computed venography |
title | Treatment of Acute Superior Sagittal Sinus Thrombosis by t-PA Infusion via Venography—Direct Thrombolytic Therapy in the Acute Phase |
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