Potent, low molecular weight renin inhibitors containing a C-terminal heterocycle: hydrogen bonding at the active site

A series of low-nanomolar renin inhibitors containing novel C-terminal heterocycles has been designed by formally cyclizing the C-terminus of a glycol-based inhibitor to the second hydroxyl. Molecular modeling suggests that the heterocyclic oxygen hydrogen bonds as an acceptor to the flap region of...

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Veröffentlicht in:Journal of medicinal chemistry 1990-06, Vol.33 (6), p.1582-1590
Hauptverfasser: Rosenberg, Saul H, Dellaria, Joseph F, Kempf, Dale J, Hutchins, Charles W, Woods, Keith W, Maki, Robert G, De Lara, Ed, Spina, Kenneth P, Stein, Herman H
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Sprache:eng
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Zusammenfassung:A series of low-nanomolar renin inhibitors containing novel C-terminal heterocycles has been designed by formally cyclizing the C-terminus of a glycol-based inhibitor to the second hydroxyl. Molecular modeling suggests that the heterocyclic oxygen hydrogen bonds as an acceptor to the flap region of renin and that the second hydroxyl in the glycol-based inhibitors behaves similarly.
ISSN:0022-2623
1520-4804
DOI:10.1021/jm00168a009