Nutritional folate-deficiency in Chinese hamster ovary cells: Chromosomal abnormalities associated with perturbations in nucleic acid precursors

Folate deficiency is known to induce chromosomal abnormalities. We used a nutritionally folate-deficient Chinese hamster ovary (CHO) cell culture system to examine modulation of chromosome damage by purine or pyrimidine supplementation. The cells were cultured in folate-deficient (Fol −) medium or F...

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Veröffentlicht in:	Cancer genetics and cytogenetics 1990-06, Vol.46 (2), p.231-242
Hauptverfasser:	Libbus, Bisharah L., Borman, Linda S., Ventrone, Cassandra H., Branda, Richard F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Cycle Cell Line Chromosome Aberrations Cricetinae Cricetulus Culture Media Folic Acid Deficiency - genetics Folic Acid Deficiency - metabolism Hypoxanthine Hypoxanthines - metabolism Hypoxanthines - pharmacology Karyotyping Medical sciences Metabolic diseases Mitotic Index Nucleic Acid Precursors - metabolism Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...) Thymidine - metabolism Thymidine - pharmacology
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