Rescue of cells from apoptosis by inhibition of active GSH extrusion

Cells induced to apoptosis extrude glutathione in the reduced form concomitantly with (U937 cells) or before (HepG2 cells) the development of apoptosis, much earlier than plasma membrane leakage. Two specific inhibitors of carrier‐mediated GSH extrusion, methionine or cystathionine, are able to decr...

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Veröffentlicht in:	The FASEB journal 1998-04, Vol.12 (6), p.479-486
Hauptverfasser:	Ghibelli, L., Fanelli, C., Rotilio, G., Lafavia, E., Coppola, S., Colussi, C., Civitareale, P., Ciriolo, M. R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Cell Line cystathionine Cystathionine - pharmacology Glutathione - antagonists & inhibitors GSH efflux Humans methionine Methionine - pharmacology puromycin Puromycin - pharmacology
Online-Zugang:	Volltext
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