Target tissue uptake selectivity of three fluorine-substituted progestins: Potential imaging agents for receptor-positive breast tumors

We have studied three new fluorine-substituted progestins ( 1–3) as potential imaging agents for progesterone receptor (PgR)-positive human breast tumors. Two of these are fluorine-substituted analogs of the potent progestin R5020 (promegestone), derived from (21S)-hydroxy R 5020 (RU 27987) and (21...

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Veröffentlicht in:	International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology Nuclear medicine and biology, 1990, Vol.17 (3), p.309-319
Hauptverfasser:	Pomper, Martin G., Pinney, Kevin G., Carlson, Kathryn E., Van Brocklin, Henry, Mathias, Carla J., Welch, Michael J., Katzenellenbogen, John A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Breast Neoplasms - diagnostic imaging Female Humans Investigative techniques, diagnostic techniques (general aspects) Medical sciences Neoplasms, Hormone-Dependent - diagnostic imaging Norpregnadienes - pharmacokinetics Pregnenediones - chemical synthesis Pregnenediones - pharmacokinetics Promegestone - analogs & derivatives Promegestone - chemical synthesis Promegestone - pharmacokinetics Radionuclide Imaging Rats Rats, Inbred Strains Tissue Distribution
Online-Zugang:	Volltext
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