Heparin free hemodialysis does not cause fibrin consumptive coagulopathy and maintains alternate pathway complement activation
Heparin-free hemodialysis allows demonstration of the intradialytic coagulation status not previously possible during standard heparin anticoagulant hemodialysis protocols in patients with end-stage renal disease. No evidence for consumptive coagulopathy was noted in the absence of heparin during he...
Gespeichert in:
| Veröffentlicht in: | ASAIO transactions 1990-04, Vol.36 (2), p.86-89 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 89 |
|---|---|
| container_issue | 2 |
| container_start_page | 86 |
| container_title | ASAIO transactions |
| container_volume | 36 |
| creator | Liboro, R Schwartz, A B Conroy, J Brezin, J Vanderlinde, R E Krevolin, L Brodsky, I |
| description | Heparin-free hemodialysis allows demonstration of the intradialytic coagulation status not previously possible during standard heparin anticoagulant hemodialysis protocols in patients with end-stage renal disease. No evidence for consumptive coagulopathy was noted in the absence of heparin during hemodialysis with cuprophane hollow fiber dialyzers. Fibrinogen levels, euglobulin lysis time, and platelet counts remained stable throughout 3 hours of heparin-free hemodialysis. Serial thrombin times and platelet aggregation improved during heparin-free hemodialysis. Hemodialyzer volumes and the ultrafiltration coefficient decreased only minimally. The alternate pathway of complement activation associated with hemodialysis blood-membrane interaction is not prevented by heparin-free hemodialysis. |
| doi_str_mv | 10.1097/00002216-199004000-00008 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79773705</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>79773705</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1022-695f0021b3bc04b94e5a591d82538c6f98594e346662180c3776bec01f589d483</originalsourceid><addsrcrecordid>eNo9kMFOxCAQhjlo1nX1EUw4eatCaQsczUZdExMvem4onbqYArVQzV58dqm7LsmE4Z9_mMyHEKbkhhLJb0k6eU6rjEpJSJFe2SyJE7QkQsiMU0nO0HkIH4QwxgldoEXOCpLTfIl-NjCo0TjcjQB4C9a3RvW7YAJuPQTsfMRaTQFwZ5rZp70Lkx2i-YKUq_ep94OK2x1WrsVWGRdTBKz6CKNTEfBc_Va7ZLZDDxZcxEqndhWNdxfotFN9gMvDvUJvD_ev6032_PL4tL57zjRNu2WVLLu0JG1Yo0nRyAJKVUrairxkQledFGXSWFFVVU4F0YzzqgFNaFcK2RaCrdD1_t9h9J8ThFhbEzT0vXLgp1BzyXlCUyaj2Bv16EMYoauH0Vg17mpK6hl3_Y-7PuL-k-YZV4cZU2OhPTYeWLNfPyh-1g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79773705</pqid></control><display><type>article</type><title>Heparin free hemodialysis does not cause fibrin consumptive coagulopathy and maintains alternate pathway complement activation</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>Liboro, R ; Schwartz, A B ; Conroy, J ; Brezin, J ; Vanderlinde, R E ; Krevolin, L ; Brodsky, I</creator><creatorcontrib>Liboro, R ; Schwartz, A B ; Conroy, J ; Brezin, J ; Vanderlinde, R E ; Krevolin, L ; Brodsky, I</creatorcontrib><description>Heparin-free hemodialysis allows demonstration of the intradialytic coagulation status not previously possible during standard heparin anticoagulant hemodialysis protocols in patients with end-stage renal disease. No evidence for consumptive coagulopathy was noted in the absence of heparin during hemodialysis with cuprophane hollow fiber dialyzers. Fibrinogen levels, euglobulin lysis time, and platelet counts remained stable throughout 3 hours of heparin-free hemodialysis. Serial thrombin times and platelet aggregation improved during heparin-free hemodialysis. Hemodialyzer volumes and the ultrafiltration coefficient decreased only minimally. The alternate pathway of complement activation associated with hemodialysis blood-membrane interaction is not prevented by heparin-free hemodialysis.</description><identifier>ISSN: 0889-7190</identifier><identifier>DOI: 10.1097/00002216-199004000-00008</identifier><identifier>PMID: 2340212</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Aged ; Blood Coagulation ; Complement Activation ; Complement Pathway, Alternative ; Female ; Fibrinogen - metabolism ; Heparin ; Humans ; Leukocyte Count ; Male ; Middle Aged ; Platelet Adhesiveness ; Platelet Aggregation ; Platelet Count ; Renal Dialysis - methods</subject><ispartof>ASAIO transactions, 1990-04, Vol.36 (2), p.86-89</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2340212$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liboro, R</creatorcontrib><creatorcontrib>Schwartz, A B</creatorcontrib><creatorcontrib>Conroy, J</creatorcontrib><creatorcontrib>Brezin, J</creatorcontrib><creatorcontrib>Vanderlinde, R E</creatorcontrib><creatorcontrib>Krevolin, L</creatorcontrib><creatorcontrib>Brodsky, I</creatorcontrib><title>Heparin free hemodialysis does not cause fibrin consumptive coagulopathy and maintains alternate pathway complement activation</title><title>ASAIO transactions</title><addtitle>ASAIO Trans</addtitle><description>Heparin-free hemodialysis allows demonstration of the intradialytic coagulation status not previously possible during standard heparin anticoagulant hemodialysis protocols in patients with end-stage renal disease. No evidence for consumptive coagulopathy was noted in the absence of heparin during hemodialysis with cuprophane hollow fiber dialyzers. Fibrinogen levels, euglobulin lysis time, and platelet counts remained stable throughout 3 hours of heparin-free hemodialysis. Serial thrombin times and platelet aggregation improved during heparin-free hemodialysis. Hemodialyzer volumes and the ultrafiltration coefficient decreased only minimally. The alternate pathway of complement activation associated with hemodialysis blood-membrane interaction is not prevented by heparin-free hemodialysis.</description><subject>Adult</subject><subject>Aged</subject><subject>Blood Coagulation</subject><subject>Complement Activation</subject><subject>Complement Pathway, Alternative</subject><subject>Female</subject><subject>Fibrinogen - metabolism</subject><subject>Heparin</subject><subject>Humans</subject><subject>Leukocyte Count</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Platelet Adhesiveness</subject><subject>Platelet Aggregation</subject><subject>Platelet Count</subject><subject>Renal Dialysis - methods</subject><issn>0889-7190</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMFOxCAQhjlo1nX1EUw4eatCaQsczUZdExMvem4onbqYArVQzV58dqm7LsmE4Z9_mMyHEKbkhhLJb0k6eU6rjEpJSJFe2SyJE7QkQsiMU0nO0HkIH4QwxgldoEXOCpLTfIl-NjCo0TjcjQB4C9a3RvW7YAJuPQTsfMRaTQFwZ5rZp70Lkx2i-YKUq_ep94OK2x1WrsVWGRdTBKz6CKNTEfBc_Va7ZLZDDxZcxEqndhWNdxfotFN9gMvDvUJvD_ev6032_PL4tL57zjRNu2WVLLu0JG1Yo0nRyAJKVUrairxkQledFGXSWFFVVU4F0YzzqgFNaFcK2RaCrdD1_t9h9J8ThFhbEzT0vXLgp1BzyXlCUyaj2Bv16EMYoauH0Vg17mpK6hl3_Y-7PuL-k-YZV4cZU2OhPTYeWLNfPyh-1g</recordid><startdate>199004</startdate><enddate>199004</enddate><creator>Liboro, R</creator><creator>Schwartz, A B</creator><creator>Conroy, J</creator><creator>Brezin, J</creator><creator>Vanderlinde, R E</creator><creator>Krevolin, L</creator><creator>Brodsky, I</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199004</creationdate><title>Heparin free hemodialysis does not cause fibrin consumptive coagulopathy and maintains alternate pathway complement activation</title><author>Liboro, R ; Schwartz, A B ; Conroy, J ; Brezin, J ; Vanderlinde, R E ; Krevolin, L ; Brodsky, I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1022-695f0021b3bc04b94e5a591d82538c6f98594e346662180c3776bec01f589d483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Blood Coagulation</topic><topic>Complement Activation</topic><topic>Complement Pathway, Alternative</topic><topic>Female</topic><topic>Fibrinogen - metabolism</topic><topic>Heparin</topic><topic>Humans</topic><topic>Leukocyte Count</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Platelet Adhesiveness</topic><topic>Platelet Aggregation</topic><topic>Platelet Count</topic><topic>Renal Dialysis - methods</topic><toplevel>online_resources</toplevel><creatorcontrib>Liboro, R</creatorcontrib><creatorcontrib>Schwartz, A B</creatorcontrib><creatorcontrib>Conroy, J</creatorcontrib><creatorcontrib>Brezin, J</creatorcontrib><creatorcontrib>Vanderlinde, R E</creatorcontrib><creatorcontrib>Krevolin, L</creatorcontrib><creatorcontrib>Brodsky, I</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>ASAIO transactions</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liboro, R</au><au>Schwartz, A B</au><au>Conroy, J</au><au>Brezin, J</au><au>Vanderlinde, R E</au><au>Krevolin, L</au><au>Brodsky, I</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Heparin free hemodialysis does not cause fibrin consumptive coagulopathy and maintains alternate pathway complement activation</atitle><jtitle>ASAIO transactions</jtitle><addtitle>ASAIO Trans</addtitle><date>1990-04</date><risdate>1990</risdate><volume>36</volume><issue>2</issue><spage>86</spage><epage>89</epage><pages>86-89</pages><issn>0889-7190</issn><abstract>Heparin-free hemodialysis allows demonstration of the intradialytic coagulation status not previously possible during standard heparin anticoagulant hemodialysis protocols in patients with end-stage renal disease. No evidence for consumptive coagulopathy was noted in the absence of heparin during hemodialysis with cuprophane hollow fiber dialyzers. Fibrinogen levels, euglobulin lysis time, and platelet counts remained stable throughout 3 hours of heparin-free hemodialysis. Serial thrombin times and platelet aggregation improved during heparin-free hemodialysis. Hemodialyzer volumes and the ultrafiltration coefficient decreased only minimally. The alternate pathway of complement activation associated with hemodialysis blood-membrane interaction is not prevented by heparin-free hemodialysis.</abstract><cop>United States</cop><pmid>2340212</pmid><doi>10.1097/00002216-199004000-00008</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0889-7190 |
| ispartof | ASAIO transactions, 1990-04, Vol.36 (2), p.86-89 |
| issn | 0889-7190 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_79773705 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Aged Blood Coagulation Complement Activation Complement Pathway, Alternative Female Fibrinogen - metabolism Heparin Humans Leukocyte Count Male Middle Aged Platelet Adhesiveness Platelet Aggregation Platelet Count Renal Dialysis - methods |
| title | Heparin free hemodialysis does not cause fibrin consumptive coagulopathy and maintains alternate pathway complement activation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T05%3A08%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Heparin%20free%20hemodialysis%20does%20not%20cause%20fibrin%20consumptive%20coagulopathy%20and%20maintains%20alternate%20pathway%20complement%20activation&rft.jtitle=ASAIO%20transactions&rft.au=Liboro,%20R&rft.date=1990-04&rft.volume=36&rft.issue=2&rft.spage=86&rft.epage=89&rft.pages=86-89&rft.issn=0889-7190&rft_id=info:doi/10.1097/00002216-199004000-00008&rft_dat=%3Cproquest_cross%3E79773705%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=79773705&rft_id=info:pmid/2340212&rfr_iscdi=true |