Improvement in Cell-Mediated Immune Function during Potent Anti-Human Immunodeficiency Virus Therapy with Ritonavir plus Saquinavir

Inhibiting human immunodeficiency virus (HIV) replication with potent antiretroviral therapy may result in improved immune function, and this may lead to favorable outcomes, independent of changes in CD4+ lymphocyte count. The effect of combination protease inhibitor therapy (ritonavir plus saquinav...

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Veröffentlicht in:	The Journal of infectious diseases 1998-04, Vol.177 (4), p.898-904
Hauptverfasser:	Angel, Jonathan B., Kumar, Ashok, Parato, Karl, Filion, Lionel G., Diaz-Mitoma, Francisco, Daftarian, Pirouz, Pham, Ba', Sun, Eugene, Leonard, John M., Cameron, D. William
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Antibiotics. Antiinfectious agents. Antiparasitic agents Antigens Antiretrovirals Antiviral agents Biological and medical sciences Blood Blood plasma CD28 Antigens - immunology CD28 Antigens - metabolism CD4 Lymphocyte Count CD8-Positive T-Lymphocytes - immunology Cell Division Cytokines Drug Therapy, Combination Flow Cytometry HIV HIV - isolation & purification HIV Infections - drug therapy HIV Infections - immunology HIV Protease Inhibitors - administration & dosage HIV Protease Inhibitors - therapeutic use Humans Immunity, Cellular Interleukin-10 - metabolism Interleukin-12 - metabolism Interleukin-2 - metabolism Leukocytes, Mononuclear - cytology Leukocytes, Mononuclear - immunology Lymphocytes Major Articles Medical sciences Pharmacology. Drug treatments Phytohemagglutinins - immunology Ritonavir - administration & dosage Ritonavir - therapeutic use RNA RNA, Viral - isolation & purification Saquinavir - administration & dosage Saquinavir - therapeutic use T lymphocytes Viral Load Viruses
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