Cloning of the Canine β-Glucuronidase cDNA, Mutation Identification in Canine MPS VII, and Retroviral Vector-Mediated Correction of MPS VII Cells

Mucopolysaccharidosis type VII (MPS VII) is an inherited disease resulting from deficient activity of the lysosomal acid hydrolase β-glucuronidase (GUSB) and has been reported in humans, mice, cats, and dogs. To characterize canine MPS VII, we have isolated and sequenced the canine GUSB cDNA from no...

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Veröffentlicht in:	Genomics (San Diego, Calif.) Calif.), 1998-03, Vol.48 (2), p.248-253
Hauptverfasser:	Ray, Jharna, Bouvet, Alain, DeSanto, Christopher, Fyfe, John C., Xu, Danbin, Wolfe, John H., Aguirre, Gustavo D., Patterson, Donald F., Haskins, Mark E., Henthorn, Paula S.
Format:	Artikel
Sprache:	eng
Schlagworte:	ACTIVIDAD ENZIMATICA ACTIVITE ENZYMATIQUE ADN Amino Acid Sequence AMINO ACID SEQUENCES Amino Acid Substitution - genetics Animals Biological and medical sciences Carbohydrates (enzymatic deficiencies). Glycogenosis CELL CULTURE CELL LINES CHEMICAL COMPOSITION CHIEN COMPLEMENTARY DNA COMPOSICION QUIMICA COMPOSITION CHIMIQUE CULTIVO DE CELULAS CULTURE DE CELLULE DIRECT DNA UPTAKE DNA DNA, Complementary - biosynthesis DNA, Complementary - genetics DNA, Complementary - isolation & purification DOGS ENZYMIC ACTIVITY Errors of metabolism FIBROBLASTE FIBROBLASTOS FIBROBLASTS GENBANK/AF019759 GENE Gene Transfer Techniques GENES GENETIC TRANSFORMATION Genetic Vectors - genetics Genetic Vectors - metabolism GLICOSIDASAS Glucuronidase - deficiency Glucuronidase - genetics GLYCOSIDASE GLYCOSIDASES Humans Medical sciences Metabolic diseases METABOLIC DISORDERS Mice MOLECULAR SEQUENCE DATA MUCOPOLYSACCHARIDOSIS Mucopolysaccharidosis VII - enzymology Mucopolysaccharidosis VII - genetics Mucopolysaccharidosis VII - therapy Mucopolysaccharidosis VII - veterinary MUTACION MUTATION NUCLEOTIDE SEQUENCE NUCLEOTIDE SUBSTITUTION PERRO Point Mutation - genetics Rats RETROVIRIDAE Retroviridae - genetics SECUENCIA NUCLEOTIDICA Sequence Alignment SEQUENCE NUCLEOTIDIQUE TERAPIA THERAPEUTIQUE THERAPY TRANSFORMACION GENETICA TRANSFORMATION GENETIQUE TRASTORNOS METABOLICOS TROUBLE DU METABOLISME VECTEUR DE MALADIE VECTORES VECTORS
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