Epstein-Barr viral DNA in serum of patients with nasopharyngeal carcinoma
This study evaluated Epstein-Barr virus (EBV) DNA in sera of 42 patients with nasopharyngeal carcinoma (NPC) and 82 healthy individuals who had been infected previously with EBV. Thirteen of 42 NPC samples were positive for EBV DNA in their sera, whereas all 82 normal controls were negative. In addi...
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| Veröffentlicht in: | Clinical cancer research 1998-03, Vol.4 (3), p.665-669 |
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| creator | MUTIRANGURA, A PORNTHANAKASEM, W THEAMBOONLERS, A SRIURANPONG, V LERTSANGUANSINCHI, P YENRUDI, S VORAVUD, N SUPIYAPHUN, P POOVORAWAN, Y |
| description | This study evaluated Epstein-Barr virus (EBV) DNA in sera of 42 patients with nasopharyngeal carcinoma (NPC) and 82 healthy
individuals who had been infected previously with EBV. Thirteen of 42 NPC samples were positive for EBV DNA in their sera,
whereas all 82 normal controls were negative. In addition, EBV typing between primary tumors and sera showed identical results,
suggesting that serum EBV DNA represented tumor DNA. To evaluate the importance of the serum NPC DNA, clinical data and tumor
phenotypes including age, sex, WHO type, EBV type, stage, tumor invasion, metastasis, and apoptosis were correlated with serum
EBV DNA, and only apoptosis was found statistically significant. In conclusion, EBV DNA was detectable in the serum of some
patients with NPC, represented tumor DNA, and might have clinical implications in the future. |
| format | Article |
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individuals who had been infected previously with EBV. Thirteen of 42 NPC samples were positive for EBV DNA in their sera,
whereas all 82 normal controls were negative. In addition, EBV typing between primary tumors and sera showed identical results,
suggesting that serum EBV DNA represented tumor DNA. To evaluate the importance of the serum NPC DNA, clinical data and tumor
phenotypes including age, sex, WHO type, EBV type, stage, tumor invasion, metastasis, and apoptosis were correlated with serum
EBV DNA, and only apoptosis was found statistically significant. In conclusion, EBV DNA was detectable in the serum of some
patients with NPC, represented tumor DNA, and might have clinical implications in the future.</description><identifier>ISSN: 1078-0432</identifier><identifier>EISSN: 1557-3265</identifier><identifier>PMID: 9533535</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Adult ; Age Factors ; Apoptosis ; Biological and medical sciences ; DNA Fragmentation ; DNA, Viral - blood ; Enzyme-Linked Immunosorbent Assay ; Female ; Herpesvirus 4, Human - isolation & purification ; Humans ; Male ; Medical sciences ; Middle Aged ; Nasopharyngeal Neoplasms - blood ; Nasopharyngeal Neoplasms - pathology ; Nasopharyngeal Neoplasms - virology ; Neoplasm Invasiveness ; Neoplasm Metastasis ; Neoplasm Staging ; Otorhinolaryngology (head neck, general aspects and miscellaneous) ; Otorhinolaryngology. Stomatology ; Polymerase Chain Reaction ; Reference Values ; Tumors</subject><ispartof>Clinical cancer research, 1998-03, Vol.4 (3), p.665-669</ispartof><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2190115$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9533535$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MUTIRANGURA, A</creatorcontrib><creatorcontrib>PORNTHANAKASEM, W</creatorcontrib><creatorcontrib>THEAMBOONLERS, A</creatorcontrib><creatorcontrib>SRIURANPONG, V</creatorcontrib><creatorcontrib>LERTSANGUANSINCHI, P</creatorcontrib><creatorcontrib>YENRUDI, S</creatorcontrib><creatorcontrib>VORAVUD, N</creatorcontrib><creatorcontrib>SUPIYAPHUN, P</creatorcontrib><creatorcontrib>POOVORAWAN, Y</creatorcontrib><title>Epstein-Barr viral DNA in serum of patients with nasopharyngeal carcinoma</title><title>Clinical cancer research</title><addtitle>Clin Cancer Res</addtitle><description>This study evaluated Epstein-Barr virus (EBV) DNA in sera of 42 patients with nasopharyngeal carcinoma (NPC) and 82 healthy
individuals who had been infected previously with EBV. Thirteen of 42 NPC samples were positive for EBV DNA in their sera,
whereas all 82 normal controls were negative. In addition, EBV typing between primary tumors and sera showed identical results,
suggesting that serum EBV DNA represented tumor DNA. To evaluate the importance of the serum NPC DNA, clinical data and tumor
phenotypes including age, sex, WHO type, EBV type, stage, tumor invasion, metastasis, and apoptosis were correlated with serum
EBV DNA, and only apoptosis was found statistically significant. In conclusion, EBV DNA was detectable in the serum of some
patients with NPC, represented tumor DNA, and might have clinical implications in the future.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Apoptosis</subject><subject>Biological and medical sciences</subject><subject>DNA Fragmentation</subject><subject>DNA, Viral - blood</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Herpesvirus 4, Human - isolation & purification</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nasopharyngeal Neoplasms - blood</subject><subject>Nasopharyngeal Neoplasms - pathology</subject><subject>Nasopharyngeal Neoplasms - virology</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Metastasis</subject><subject>Neoplasm Staging</subject><subject>Otorhinolaryngology (head neck, general aspects and miscellaneous)</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Polymerase Chain Reaction</subject><subject>Reference Values</subject><subject>Tumors</subject><issn>1078-0432</issn><issn>1557-3265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFj09Lw0AUxIMoVasfQdiDeAtk_yfHWqsWil70vLxsXpqVZBN3U4vf3oBBT29gfsy8OUkuqJQ65UzJ00lnOk8zwdl5chnjR5ZRQTOxSBaF5FxyeZFsN0Mc0fn0HkIgXy5ASx5eVsR5EjEcOtLXZIDRoR8jObqxIR5iPzQQvv0eJ9hCsM73HVwlZzW0Ea_nu0zeHzdv6-d09_q0Xa92acOUGlOmqgKFwFxIYeuKoUCOQLEUlEMpeC0zpmueQ6mBUcHyoqoprXKreF5rhnyZ3P3mDqH_PGAcTeeixbYFj_0hGl1opZjOJ_BmBg9lh5UZguumt828ffJvZx-ihbYO4K2LfxijRUap_O9r3L45uoDGTiCGgBGn7Y0RhhulJP8BXrRwUg</recordid><startdate>19980301</startdate><enddate>19980301</enddate><creator>MUTIRANGURA, A</creator><creator>PORNTHANAKASEM, W</creator><creator>THEAMBOONLERS, A</creator><creator>SRIURANPONG, V</creator><creator>LERTSANGUANSINCHI, P</creator><creator>YENRUDI, S</creator><creator>VORAVUD, N</creator><creator>SUPIYAPHUN, P</creator><creator>POOVORAWAN, Y</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19980301</creationdate><title>Epstein-Barr viral DNA in serum of patients with nasopharyngeal carcinoma</title><author>MUTIRANGURA, A ; PORNTHANAKASEM, W ; THEAMBOONLERS, A ; SRIURANPONG, V ; LERTSANGUANSINCHI, P ; YENRUDI, S ; VORAVUD, N ; SUPIYAPHUN, P ; POOVORAWAN, Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h266t-26d9e44e8454cfd2e4e3ea1eb413ab43f5027f38ab7a214289df11d8c638f72e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Apoptosis</topic><topic>Biological and medical sciences</topic><topic>DNA Fragmentation</topic><topic>DNA, Viral - blood</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Herpesvirus 4, Human - isolation & purification</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nasopharyngeal Neoplasms - blood</topic><topic>Nasopharyngeal Neoplasms - pathology</topic><topic>Nasopharyngeal Neoplasms - virology</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Metastasis</topic><topic>Neoplasm Staging</topic><topic>Otorhinolaryngology (head neck, general aspects and miscellaneous)</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Polymerase Chain Reaction</topic><topic>Reference Values</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MUTIRANGURA, A</creatorcontrib><creatorcontrib>PORNTHANAKASEM, W</creatorcontrib><creatorcontrib>THEAMBOONLERS, A</creatorcontrib><creatorcontrib>SRIURANPONG, V</creatorcontrib><creatorcontrib>LERTSANGUANSINCHI, P</creatorcontrib><creatorcontrib>YENRUDI, S</creatorcontrib><creatorcontrib>VORAVUD, N</creatorcontrib><creatorcontrib>SUPIYAPHUN, P</creatorcontrib><creatorcontrib>POOVORAWAN, Y</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical cancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MUTIRANGURA, A</au><au>PORNTHANAKASEM, W</au><au>THEAMBOONLERS, A</au><au>SRIURANPONG, V</au><au>LERTSANGUANSINCHI, P</au><au>YENRUDI, S</au><au>VORAVUD, N</au><au>SUPIYAPHUN, P</au><au>POOVORAWAN, Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epstein-Barr viral DNA in serum of patients with nasopharyngeal carcinoma</atitle><jtitle>Clinical cancer research</jtitle><addtitle>Clin Cancer Res</addtitle><date>1998-03-01</date><risdate>1998</risdate><volume>4</volume><issue>3</issue><spage>665</spage><epage>669</epage><pages>665-669</pages><issn>1078-0432</issn><eissn>1557-3265</eissn><abstract>This study evaluated Epstein-Barr virus (EBV) DNA in sera of 42 patients with nasopharyngeal carcinoma (NPC) and 82 healthy
individuals who had been infected previously with EBV. Thirteen of 42 NPC samples were positive for EBV DNA in their sera,
whereas all 82 normal controls were negative. In addition, EBV typing between primary tumors and sera showed identical results,
suggesting that serum EBV DNA represented tumor DNA. To evaluate the importance of the serum NPC DNA, clinical data and tumor
phenotypes including age, sex, WHO type, EBV type, stage, tumor invasion, metastasis, and apoptosis were correlated with serum
EBV DNA, and only apoptosis was found statistically significant. In conclusion, EBV DNA was detectable in the serum of some
patients with NPC, represented tumor DNA, and might have clinical implications in the future.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>9533535</pmid><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Free E-Journal (出版社公開部分のみ）; Alma/SFX Local Collection; Highwire Press American Association for Cancer Research - AACR Journals |
| subjects | Adult Age Factors Apoptosis Biological and medical sciences DNA Fragmentation DNA, Viral - blood Enzyme-Linked Immunosorbent Assay Female Herpesvirus 4, Human - isolation & purification Humans Male Medical sciences Middle Aged Nasopharyngeal Neoplasms - blood Nasopharyngeal Neoplasms - pathology Nasopharyngeal Neoplasms - virology Neoplasm Invasiveness Neoplasm Metastasis Neoplasm Staging Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology Polymerase Chain Reaction Reference Values Tumors |
| title | Epstein-Barr viral DNA in serum of patients with nasopharyngeal carcinoma |
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