Structural Requirements for Human Inducible Nitric Oxide Synthase Substrates and Substrate Analogue Inhibitors

Inducible nitric oxide synthase (iNOS; EC 1.14.13.39) catalyzes the NADPH-dependent oxidation of one of the free guanidino nitrogens of l-Arg to form nitric oxide and l-citrulline. Analogues of l-Arg and the inhibitor, l-N 6-(1-iminoethyl)lysine, were used to define structural elements required for...

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Veröffentlicht in:	Biochemistry (Easton) 1998-03, Vol.37 (12), p.4174-4180
Hauptverfasser:	Grant, Stephan K, Green, Barbara G, Stiffey-Wilusz, Janet, Durette, Philippe L, Shah, Shrenik K, Kozarich, John W
Format:	Artikel
Sprache:	eng
Schlagworte:	Arginine - analogs & derivatives Arginine - chemistry Arginine - pharmacology Enzyme Activation - drug effects Enzyme Induction - drug effects Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Humans Hydrocarbons Lysine - analogs & derivatives Lysine - chemistry Methane - analogs & derivatives Methane - chemistry Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase - biosynthesis Nitric Oxide Synthase Type II Structure-Activity Relationship Substrate Specificity - drug effects
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