A GTPase-independent mechanism of p21-activated kinase activation. Regulation by sphingosine and other biologically active lipids

p21-activated kinases (PAKs) are serine/threonine kinases that have been identified as targets for the small GTPases Rac and Cdc42. PAKs have been implicated in cytoskeletal regulation, stimulation of mitogen-activated protein kinase cascades, and in control of the phagocyte NADPH oxidase. Membrane...

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Veröffentlicht in:	The Journal of biological chemistry 1998-04, Vol.273 (14), p.8137-8144
Hauptverfasser:	Bokoch, G M, Reilly, A M, Daniels, R H, King, C C, Olivera, A, Spiegel, S, Knaus, U G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals COS Cells Cyclin-Dependent Kinase Inhibitor p21 Cyclins - metabolism Enzyme Activation - drug effects GTP Phosphohydrolases - metabolism Mutation p21-Activated Kinases Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Sphingomyelin Phosphodiesterase - pharmacology Sphingosine - pharmacology
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