Synthesis and Platelet Aggregation-Inhibitory Activities of Novel 3-(2-Oxopropylidene)azetidin-2-one Derivatives. I

Treatment of (E)-3-(2-hydroxypropylidene)-4-methyl-1-phenylazetidin-2-one (11) with 10% Pd/C gave (E)-(12), (Z)-3-(2-oxopropylidene)-4-methyl-1-phenylazetidin-2-one (13), 3, 4-cis-(14a) and 3, 4-trans-3-(2-oxopropyl)-4-methyl-1-phenylazetidin-2-one (14b). Among them, 12 and 13 were found to show pot...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1990/02/25, Vol.38(2), pp.393-399
Hauptverfasser:	KAWASHIMA, Yutaka, SATO, Masakazu, HATADA, Yuuichi, GOTO, Jun, NAKASHIMA, Yosimoto, HATAYAMA, Katsuo, SHIBUYA, Shiroshi
Format:	Artikel
Sprache:	eng
Schlagworte:	3-(2-oxopropylidene)-4-methyl-1-phenylazetidin-2-one adenosine diphosphate Animals azetidin-2-one Azetidines - chemical synthesis Azetidines - pharmacology Azetines - chemical synthesis Chemical Phenomena Chemistry collagen Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with only one n hetero atom and condensed derivatives In Vitro Techniques Organic chemistry Platelet Aggregation - drug effects platelet aggregation inhibition Platelet Aggregation Inhibitors - chemical synthesis Preparations and properties Rabbits structure-activity relationship
Online-Zugang:	Volltext
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