Formalin-induced release of excitatory amino acids in the skin of the rat hindpaw
Application of glutamate to skin evokes pain-related behaviors [S.M. Carlton, G.L. Hargett, R.E. Coggeshall, Localization and activation of glutamate receptors in unmyelinated axons of rat glabrous skin, Neurosci. Lett., 197 (1995) 25–28; D.L. Jackson, C.B. Graff, J.D. Richardson, K.M. Hargreaves, G...
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| Veröffentlicht in: | Brain research 1998-03, Vol.787 (1), p.161-164 |
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| creator | Omote, Keiichi Kawamata, Tomoyuki Kawamata, Mikito Namiki, Akiyoshi |
| description | Application of glutamate to skin evokes pain-related behaviors [S.M. Carlton, G.L. Hargett, R.E. Coggeshall, Localization and activation of glutamate receptors in unmyelinated axons of rat glabrous skin, Neurosci. Lett., 197 (1995) 25–28; D.L. Jackson, C.B. Graff, J.D. Richardson, K.M. Hargreaves, Glutamate participates in the peripheral modulation of thermal hyperalgesia in rats, Eur. J. Pharmacol., 284 (1995) 321–325.] and peripherally-administered glutamate antagonists can prevent the nociception produced by inflammation [E.M. Davidson, R.E. Coggeshall, S.M. Carlton, Peripheral NMDA and non-NMDA glutamate receptors contribute to nociceptive behaviors in the rat formalin test, NeuroReport, 8 (1997) 941–946; Jackson et al., 1995.] In this study, the concentrations of glutamate and aspartate in the plantar of the rat hindpaws were measured before and after the subcutaneous administration of formalin. Increases in glutamate and aspartate concentrations were observed on the ipsilateral side, but not on the contralateral side, to the injection. This shows that nociception and inflammation caused by formalin injection induces the release of peripheral glutamate and aspartate, which would contribute to nociception and inflammatory pain. |
| doi_str_mv | 10.1016/S0006-8993(97)01568-0 |
| format | Article |
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Carlton, G.L. Hargett, R.E. Coggeshall, Localization and activation of glutamate receptors in unmyelinated axons of rat glabrous skin, Neurosci. Lett., 197 (1995) 25–28; D.L. Jackson, C.B. Graff, J.D. Richardson, K.M. Hargreaves, Glutamate participates in the peripheral modulation of thermal hyperalgesia in rats, Eur. J. Pharmacol., 284 (1995) 321–325.] and peripherally-administered glutamate antagonists can prevent the nociception produced by inflammation [E.M. Davidson, R.E. Coggeshall, S.M. Carlton, Peripheral NMDA and non-NMDA glutamate receptors contribute to nociceptive behaviors in the rat formalin test, NeuroReport, 8 (1997) 941–946; Jackson et al., 1995.] In this study, the concentrations of glutamate and aspartate in the plantar of the rat hindpaws were measured before and after the subcutaneous administration of formalin. Increases in glutamate and aspartate concentrations were observed on the ipsilateral side, but not on the contralateral side, to the injection. This shows that nociception and inflammation caused by formalin injection induces the release of peripheral glutamate and aspartate, which would contribute to nociception and inflammatory pain.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/S0006-8993(97)01568-0</identifier><identifier>PMID: 9518591</identifier><identifier>CODEN: BRREAP</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Animals ; Aspartate ; Aspartic Acid - metabolism ; Biological and medical sciences ; Formaldehyde - pharmacology ; Formalin test ; Fundamental and applied biological sciences. Psychology ; Glutamate ; Glutamic Acid - metabolism ; Hindlimb ; Inflammation ; Male ; Pain ; Pain Measurement ; Periphery ; Rats ; Rats, Sprague-Dawley ; Skin - drug effects ; Skin - metabolism ; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. 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Carlton, G.L. Hargett, R.E. Coggeshall, Localization and activation of glutamate receptors in unmyelinated axons of rat glabrous skin, Neurosci. Lett., 197 (1995) 25–28; D.L. Jackson, C.B. Graff, J.D. Richardson, K.M. Hargreaves, Glutamate participates in the peripheral modulation of thermal hyperalgesia in rats, Eur. J. Pharmacol., 284 (1995) 321–325.] and peripherally-administered glutamate antagonists can prevent the nociception produced by inflammation [E.M. Davidson, R.E. Coggeshall, S.M. Carlton, Peripheral NMDA and non-NMDA glutamate receptors contribute to nociceptive behaviors in the rat formalin test, NeuroReport, 8 (1997) 941–946; Jackson et al., 1995.] In this study, the concentrations of glutamate and aspartate in the plantar of the rat hindpaws were measured before and after the subcutaneous administration of formalin. Increases in glutamate and aspartate concentrations were observed on the ipsilateral side, but not on the contralateral side, to the injection. This shows that nociception and inflammation caused by formalin injection induces the release of peripheral glutamate and aspartate, which would contribute to nociception and inflammatory pain.</description><subject>Animals</subject><subject>Aspartate</subject><subject>Aspartic Acid - metabolism</subject><subject>Biological and medical sciences</subject><subject>Formaldehyde - pharmacology</subject><subject>Formalin test</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glutamate</subject><subject>Glutamic Acid - metabolism</subject><subject>Hindlimb</subject><subject>Inflammation</subject><subject>Male</subject><subject>Pain</subject><subject>Pain Measurement</subject><subject>Periphery</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Skin - drug effects</subject><subject>Skin - metabolism</subject><subject>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV1LHTEQhkOp6KntTxByIaW9WJtJNl9XIqK2IEhpex2y2VlMux_HZI_Vf2_Wczi3XuUN88xMeELICbAzYKC-_WKMqcpYK75Y_ZWBVKZi78gKjOaV4jV7T1Z75Ih8yPlvuQph2SE5tBKMtLAiP6-nNPg-jlUc203Alibs0WekU0fxKcTZz1N6pn6I40R9iG2mcaTzPdL8r4RCLTn5md6XCWv__yM56Hyf8dPuPCZ_rq9-X36vbu9uflxe3FZBKjFXRgJravQiSNFgLeuu0SUzUSsjMAAo2erQKm0bABO4l4ob0WgDQnKEWhyTz9u56zQ9bDDPbog5YN_7EadNdtpqJaxVb4KguBYGFlBuwZCmnBN2bp3i4NOzA-YW5-7VuVuEOqvdq3PHSt_JbsGmGbDdd-0kl_rpru5z8H2X_Bhi3mOcA1d6GXO-xbBYe4yYXA4Rx_InMWGYXTvFNx7yAtNNnAs</recordid><startdate>19980316</startdate><enddate>19980316</enddate><creator>Omote, Keiichi</creator><creator>Kawamata, Tomoyuki</creator><creator>Kawamata, Mikito</creator><creator>Namiki, Akiyoshi</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19980316</creationdate><title>Formalin-induced release of excitatory amino acids in the skin of the rat hindpaw</title><author>Omote, Keiichi ; Kawamata, Tomoyuki ; Kawamata, Mikito ; Namiki, Akiyoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c563t-8510b4ea3c53be454fb73c5034683ec1165d7cd679b118c2a56283b781352e143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Aspartate</topic><topic>Aspartic Acid - metabolism</topic><topic>Biological and medical sciences</topic><topic>Formaldehyde - pharmacology</topic><topic>Formalin test</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glutamate</topic><topic>Glutamic Acid - metabolism</topic><topic>Hindlimb</topic><topic>Inflammation</topic><topic>Male</topic><topic>Pain</topic><topic>Pain Measurement</topic><topic>Periphery</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Skin - drug effects</topic><topic>Skin - metabolism</topic><topic>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Omote, Keiichi</creatorcontrib><creatorcontrib>Kawamata, Tomoyuki</creatorcontrib><creatorcontrib>Kawamata, Mikito</creatorcontrib><creatorcontrib>Namiki, Akiyoshi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Omote, Keiichi</au><au>Kawamata, Tomoyuki</au><au>Kawamata, Mikito</au><au>Namiki, Akiyoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Formalin-induced release of excitatory amino acids in the skin of the rat hindpaw</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1998-03-16</date><risdate>1998</risdate><volume>787</volume><issue>1</issue><spage>161</spage><epage>164</epage><pages>161-164</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Application of glutamate to skin evokes pain-related behaviors [S.M. Carlton, G.L. Hargett, R.E. Coggeshall, Localization and activation of glutamate receptors in unmyelinated axons of rat glabrous skin, Neurosci. Lett., 197 (1995) 25–28; D.L. Jackson, C.B. Graff, J.D. Richardson, K.M. Hargreaves, Glutamate participates in the peripheral modulation of thermal hyperalgesia in rats, Eur. J. Pharmacol., 284 (1995) 321–325.] and peripherally-administered glutamate antagonists can prevent the nociception produced by inflammation [E.M. Davidson, R.E. Coggeshall, S.M. Carlton, Peripheral NMDA and non-NMDA glutamate receptors contribute to nociceptive behaviors in the rat formalin test, NeuroReport, 8 (1997) 941–946; Jackson et al., 1995.] In this study, the concentrations of glutamate and aspartate in the plantar of the rat hindpaws were measured before and after the subcutaneous administration of formalin. Increases in glutamate and aspartate concentrations were observed on the ipsilateral side, but not on the contralateral side, to the injection. This shows that nociception and inflammation caused by formalin injection induces the release of peripheral glutamate and aspartate, which would contribute to nociception and inflammatory pain.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>9518591</pmid><doi>10.1016/S0006-8993(97)01568-0</doi><tpages>4</tpages></addata></record> |
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| subjects | Animals Aspartate Aspartic Acid - metabolism Biological and medical sciences Formaldehyde - pharmacology Formalin test Fundamental and applied biological sciences. Psychology Glutamate Glutamic Acid - metabolism Hindlimb Inflammation Male Pain Pain Measurement Periphery Rats Rats, Sprague-Dawley Skin - drug effects Skin - metabolism Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Vertebrates: nervous system and sense organs |
| title | Formalin-induced release of excitatory amino acids in the skin of the rat hindpaw |
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