Sexually dimorphic MK801-induced c-fos in the rat hypothalamic paraventricular nucleus
MK801 induces Fos-like immunoreactivity (FLI) in the paraventricular nucleus (PVN) in a sex, age, hormone and dosage dependent manner. MK801 (1.0 mg/kg) elicited greater behavioural disruption, but less FLI in the PVN of cycling and lactating female rats, compared to like-treated males. Results from...
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| Veröffentlicht in: | Neuroscience letters 1998-02, Vol.242 (3), p.151-154 |
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| creator | Wintrip, N Nance, D.M Wilkinson, M |
| description | MK801 induces Fos-like immunoreactivity (FLI) in the paraventricular nucleus (PVN) in a sex, age, hormone and dosage dependent manner. MK801 (1.0 mg/kg) elicited greater behavioural disruption, but less FLI in the PVN of cycling and lactating female rats, compared to like-treated males. Results from gonadectomized rats with or without acute steroid replacement resembled those seen in intact rats but sex differences were extinguished. At a lower dose (0.1 mg/kg), behavioural effects were diminished but females exhibited more behavioural disruption. At this dose however, more FLI was seen in the PVN of females compared to males, but only male-lactating female differences were significant. Taken together, the data suggest that the action of MK801 on the PVN is influenced by gonadal steroids. |
| doi_str_mv | 10.1016/S0304-3940(98)00069-X |
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MK801 (1.0 mg/kg) elicited greater behavioural disruption, but less FLI in the PVN of cycling and lactating female rats, compared to like-treated males. Results from gonadectomized rats with or without acute steroid replacement resembled those seen in intact rats but sex differences were extinguished. At a lower dose (0.1 mg/kg), behavioural effects were diminished but females exhibited more behavioural disruption. At this dose however, more FLI was seen in the PVN of females compared to males, but only male-lactating female differences were significant. Taken together, the data suggest that the action of MK801 on the PVN is influenced by gonadal steroids.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/S0304-3940(98)00069-X</identifier><identifier>PMID: 9530928</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Androgen ; Animals ; Antineoplastic Agents, Hormonal - pharmacology ; Behavior, Animal - physiology ; Behavioural effects ; Biological and medical sciences ; Dizocilpine ; Dizocilpine Maleate - pharmacology ; Estradiol - pharmacology ; Estrogen ; Excitatory Amino Acid Antagonists - pharmacology ; Female ; Fundamental and applied biological sciences. Psychology ; Hormones and neuropeptides. Regulation ; Hypothalamus. Hypophysis. Epiphysis. Urophysis ; Image processing ; Immunohistochemistry ; Lactation - physiology ; Male ; Morphometry ; Paraventricular Hypothalamic Nucleus - chemistry ; Paraventricular nucleus ; Proto-Oncogene Proteins c-fos - analysis ; Quantitative immunocytochemistry ; Rats ; Rats, Sprague-Dawley ; Sex Characteristics ; Testosterone - pharmacology ; Vertebrates: endocrinology</subject><ispartof>Neuroscience letters, 1998-02, Vol.242 (3), p.151-154</ispartof><rights>1998 Elsevier Science Ireland Ltd</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-30917ef90f1c0c5e95f8074ac7cb9f82be469d690d01afee9fd7f117d72946963</citedby><cites>FETCH-LOGICAL-c420t-30917ef90f1c0c5e95f8074ac7cb9f82be469d690d01afee9fd7f117d72946963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S030439409800069X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2159924$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9530928$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wintrip, N</creatorcontrib><creatorcontrib>Nance, D.M</creatorcontrib><creatorcontrib>Wilkinson, M</creatorcontrib><title>Sexually dimorphic MK801-induced c-fos in the rat hypothalamic paraventricular nucleus</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>MK801 induces Fos-like immunoreactivity (FLI) in the paraventricular nucleus (PVN) in a sex, age, hormone and dosage dependent manner. MK801 (1.0 mg/kg) elicited greater behavioural disruption, but less FLI in the PVN of cycling and lactating female rats, compared to like-treated males. Results from gonadectomized rats with or without acute steroid replacement resembled those seen in intact rats but sex differences were extinguished. At a lower dose (0.1 mg/kg), behavioural effects were diminished but females exhibited more behavioural disruption. At this dose however, more FLI was seen in the PVN of females compared to males, but only male-lactating female differences were significant. Taken together, the data suggest that the action of MK801 on the PVN is influenced by gonadal steroids.</description><subject>Androgen</subject><subject>Animals</subject><subject>Antineoplastic Agents, Hormonal - pharmacology</subject><subject>Behavior, Animal - physiology</subject><subject>Behavioural effects</subject><subject>Biological and medical sciences</subject><subject>Dizocilpine</subject><subject>Dizocilpine Maleate - pharmacology</subject><subject>Estradiol - pharmacology</subject><subject>Estrogen</subject><subject>Excitatory Amino Acid Antagonists - pharmacology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hormones and neuropeptides. Regulation</subject><subject>Hypothalamus. Hypophysis. Epiphysis. Urophysis</subject><subject>Image processing</subject><subject>Immunohistochemistry</subject><subject>Lactation - physiology</subject><subject>Male</subject><subject>Morphometry</subject><subject>Paraventricular Hypothalamic Nucleus - chemistry</subject><subject>Paraventricular nucleus</subject><subject>Proto-Oncogene Proteins c-fos - analysis</subject><subject>Quantitative immunocytochemistry</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Sex Characteristics</subject><subject>Testosterone - pharmacology</subject><subject>Vertebrates: endocrinology</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUlPHDEQRq0oiAyEn4DUhygKh4Zyb-46RRGCJAooBxZxszx2WePIvcTuRsy_x8OM5orq4MP3atEzY6cczjnw5uIOSqjyEiv4hu0ZADSYP31gC96KIhcoio9ssUc-saMY_yWo5nV1yA6xLgGLdsEe7-hlVt6vM-O6IYwrp7PbPy3w3PVm1mQyndshZq7PphVlQU3Zaj0O00p51SV2VEE9Uz8Fp2evQtbP2tMcP7MDq3ykk917zB6ur-4vf-U3f3_-vvxxk-uqgClPR3BBFsFyDbomrG0LolJa6CXatlhS1aBpEAxwZYnQGmE5F0YUmJKmPGZft3PHMPyfKU6yc1GT96qnYY4yeWjKKtV7IG9KFEJswHoL6jDEGMjKMbhOhbXkIDfi5Zt4ubEqsZVv4uVT6jvdLZiXHZl91850yr_schW18jaoXru4xwpeIxab9d-3GCVrz46CjNpRnz7CBdKTNIN755BXHIGfgQ</recordid><startdate>19980220</startdate><enddate>19980220</enddate><creator>Wintrip, N</creator><creator>Nance, D.M</creator><creator>Wilkinson, M</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19980220</creationdate><title>Sexually dimorphic MK801-induced c-fos in the rat hypothalamic paraventricular nucleus</title><author>Wintrip, N ; Nance, D.M ; Wilkinson, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-30917ef90f1c0c5e95f8074ac7cb9f82be469d690d01afee9fd7f117d72946963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Androgen</topic><topic>Animals</topic><topic>Antineoplastic Agents, Hormonal - pharmacology</topic><topic>Behavior, Animal - physiology</topic><topic>Behavioural effects</topic><topic>Biological and medical sciences</topic><topic>Dizocilpine</topic><topic>Dizocilpine Maleate - pharmacology</topic><topic>Estradiol - pharmacology</topic><topic>Estrogen</topic><topic>Excitatory Amino Acid Antagonists - pharmacology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hormones and neuropeptides. Regulation</topic><topic>Hypothalamus. Hypophysis. Epiphysis. Urophysis</topic><topic>Image processing</topic><topic>Immunohistochemistry</topic><topic>Lactation - physiology</topic><topic>Male</topic><topic>Morphometry</topic><topic>Paraventricular Hypothalamic Nucleus - chemistry</topic><topic>Paraventricular nucleus</topic><topic>Proto-Oncogene Proteins c-fos - analysis</topic><topic>Quantitative immunocytochemistry</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Sex Characteristics</topic><topic>Testosterone - pharmacology</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wintrip, N</creatorcontrib><creatorcontrib>Nance, D.M</creatorcontrib><creatorcontrib>Wilkinson, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wintrip, N</au><au>Nance, D.M</au><au>Wilkinson, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sexually dimorphic MK801-induced c-fos in the rat hypothalamic paraventricular nucleus</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1998-02-20</date><risdate>1998</risdate><volume>242</volume><issue>3</issue><spage>151</spage><epage>154</epage><pages>151-154</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>MK801 induces Fos-like immunoreactivity (FLI) in the paraventricular nucleus (PVN) in a sex, age, hormone and dosage dependent manner. MK801 (1.0 mg/kg) elicited greater behavioural disruption, but less FLI in the PVN of cycling and lactating female rats, compared to like-treated males. Results from gonadectomized rats with or without acute steroid replacement resembled those seen in intact rats but sex differences were extinguished. At a lower dose (0.1 mg/kg), behavioural effects were diminished but females exhibited more behavioural disruption. At this dose however, more FLI was seen in the PVN of females compared to males, but only male-lactating female differences were significant. Taken together, the data suggest that the action of MK801 on the PVN is influenced by gonadal steroids.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>9530928</pmid><doi>10.1016/S0304-3940(98)00069-X</doi><tpages>4</tpages></addata></record> |
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| ispartof | Neuroscience letters, 1998-02, Vol.242 (3), p.151-154 |
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| subjects | Androgen Animals Antineoplastic Agents, Hormonal - pharmacology Behavior, Animal - physiology Behavioural effects Biological and medical sciences Dizocilpine Dizocilpine Maleate - pharmacology Estradiol - pharmacology Estrogen Excitatory Amino Acid Antagonists - pharmacology Female Fundamental and applied biological sciences. Psychology Hormones and neuropeptides. Regulation Hypothalamus. Hypophysis. Epiphysis. Urophysis Image processing Immunohistochemistry Lactation - physiology Male Morphometry Paraventricular Hypothalamic Nucleus - chemistry Paraventricular nucleus Proto-Oncogene Proteins c-fos - analysis Quantitative immunocytochemistry Rats Rats, Sprague-Dawley Sex Characteristics Testosterone - pharmacology Vertebrates: endocrinology |
| title | Sexually dimorphic MK801-induced c-fos in the rat hypothalamic paraventricular nucleus |
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