Evidence for cAMP-independent mechanisms mediating the effects of adrenomedullin, a new inotropic peptide

Adrenomedullin (ADM), a new vasorelaxing and natriuretic peptide, may function as an endogenous regulator of cardiac function, because ADM and its binding sites have been found in the heart. We characterize herein the cardiac effects of ADM as well as the underlying signaling pathways in vitro. In i...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 1998-03, Vol.97 (11), p.1062-1070
Hauptverfasser:	SZOKODI, I, KINNUNEN, P, TAVI, P, WECKSTRÖM, M, TOTH, M, RUSKOAHO, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Adrenomedullin Animals Atrial Natriuretic Factor - metabolism Biological and medical sciences Calcium - metabolism Calcium Channels - drug effects Cardiology. Vascular system Cardiotonic Agents - pharmacology Cyclic AMP - physiology Heart Heart failure, cardiogenic pulmonary edema, cardiac enlargement Hemodynamics - drug effects Male Medical sciences Myocardial Contraction - drug effects Myocardium - metabolism Organ Culture Techniques Peptides - pharmacology Rats Rats, Sprague-Dawley Second Messenger Systems Signal Transduction
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