Apolipoprotein E4 reduces risk of diabetic nephropathy in patients with NIDDM
Hypercholesterolemia is a major determinant of the decline of renal function in patients with diabetes. Apolipoprotein E polymorphism may influence the metabolism of lipoprotein in diabetic patients. The purpose of this study was to investigate the association between genetic polymorphisms in apolip...
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| Veröffentlicht in: | American journal of kidney diseases 1998-04, Vol.31 (4), p.666-673 |
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| creator | Kimura, H Suzuki, Y Gejyo, F Karasawa, R Miyazaki, R Suzuki, S Arakawa, M |
| description | Hypercholesterolemia is a major determinant of the decline of renal function in patients with diabetes. Apolipoprotein E polymorphism may influence the metabolism of lipoprotein in diabetic patients. The purpose of this study was to investigate the association between genetic polymorphisms in apolipoprotein E and the progression of diabetic nephropathy in patients with non-insulin-dependent diabetes mellitus over a 10-year period (13 to 37 years; median, 20 years). Subjects with a stable renal function without overt proteinuria had a higher cholesterol level, lower incidences of hypertension and proliferative diabetic retinopathy, and a higher frequency of the E4 allele than subjects with a decline in renal function (end-stage renal failure requiring dialysis treatment). In the diabetic patients, the apolipoprotein E4 carriers had a higher cholesterol level than did the noncarriers. The survival rate from renal disease in the apolipoprotein E4 carriers was higher than in the noncarriers among the diabetic patients. Apolipoprotein E polymorphism and hypertension were identified as independent risk factors for the progression to renal failure. Results indicate that apolipoprotein E polymorphism is associated with the progression of diabetic nephropathy. Presence of the apolipoprotein E4 allele is a protective factor, and other alleles are risk factors. (Am J Kidney Dis 1998 Apr;31(4):666-73) |
| doi_str_mv | 10.1053/ajkd.1998.v31.pm9531184 |
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Apolipoprotein E polymorphism may influence the metabolism of lipoprotein in diabetic patients. The purpose of this study was to investigate the association between genetic polymorphisms in apolipoprotein E and the progression of diabetic nephropathy in patients with non-insulin-dependent diabetes mellitus over a 10-year period (13 to 37 years; median, 20 years). Subjects with a stable renal function without overt proteinuria had a higher cholesterol level, lower incidences of hypertension and proliferative diabetic retinopathy, and a higher frequency of the E4 allele than subjects with a decline in renal function (end-stage renal failure requiring dialysis treatment). In the diabetic patients, the apolipoprotein E4 carriers had a higher cholesterol level than did the noncarriers. The survival rate from renal disease in the apolipoprotein E4 carriers was higher than in the noncarriers among the diabetic patients. Apolipoprotein E polymorphism and hypertension were identified as independent risk factors for the progression to renal failure. Results indicate that apolipoprotein E polymorphism is associated with the progression of diabetic nephropathy. Presence of the apolipoprotein E4 allele is a protective factor, and other alleles are risk factors. (Am J Kidney Dis 1998 Apr;31(4):666-73)</description><identifier>ISSN: 0272-6386</identifier><identifier>EISSN: 1523-6838</identifier><identifier>DOI: 10.1053/ajkd.1998.v31.pm9531184</identifier><identifier>PMID: 9531184</identifier><language>eng</language><publisher>Orlando, FL: Elsevier Inc</publisher><subject>Adult ; Aged ; Alleles ; Apolipoprotein E4 ; Apolipoproteins E - blood ; Apolipoproteins E - genetics ; Associated diseases and complications ; Biological and medical sciences ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - genetics ; Diabetes. Impaired glucose tolerance ; Diabetic Nephropathies - blood ; Diabetic Nephropathies - etiology ; Diabetic Nephropathies - genetics ; Disease Progression ; DNA - blood ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Female ; Genotype ; Humans ; Kidney Failure, Chronic - blood ; Kidney Failure, Chronic - genetics ; Kidney Failure, Chronic - therapy ; Male ; Medical sciences ; Middle Aged ; Phenotype ; Polymorphism, Genetic - genetics ; Renal Dialysis ; Risk Factors ; Time Factors</subject><ispartof>American journal of kidney diseases, 1998-04, Vol.31 (4), p.666-673</ispartof><rights>1998</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-bc21322f903bc6d71339a798c29818453bc1146c4803d45487d5d4ff22101003</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0272638698000997$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2201333$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9531184$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kimura, H</creatorcontrib><creatorcontrib>Suzuki, Y</creatorcontrib><creatorcontrib>Gejyo, F</creatorcontrib><creatorcontrib>Karasawa, R</creatorcontrib><creatorcontrib>Miyazaki, R</creatorcontrib><creatorcontrib>Suzuki, S</creatorcontrib><creatorcontrib>Arakawa, M</creatorcontrib><title>Apolipoprotein E4 reduces risk of diabetic nephropathy in patients with NIDDM</title><title>American journal of kidney diseases</title><addtitle>Am J Kidney Dis</addtitle><description>Hypercholesterolemia is a major determinant of the decline of renal function in patients with diabetes. Apolipoprotein E polymorphism may influence the metabolism of lipoprotein in diabetic patients. The purpose of this study was to investigate the association between genetic polymorphisms in apolipoprotein E and the progression of diabetic nephropathy in patients with non-insulin-dependent diabetes mellitus over a 10-year period (13 to 37 years; median, 20 years). Subjects with a stable renal function without overt proteinuria had a higher cholesterol level, lower incidences of hypertension and proliferative diabetic retinopathy, and a higher frequency of the E4 allele than subjects with a decline in renal function (end-stage renal failure requiring dialysis treatment). In the diabetic patients, the apolipoprotein E4 carriers had a higher cholesterol level than did the noncarriers. The survival rate from renal disease in the apolipoprotein E4 carriers was higher than in the noncarriers among the diabetic patients. Apolipoprotein E polymorphism and hypertension were identified as independent risk factors for the progression to renal failure. Results indicate that apolipoprotein E polymorphism is associated with the progression of diabetic nephropathy. Presence of the apolipoprotein E4 allele is a protective factor, and other alleles are risk factors. (Am J Kidney Dis 1998 Apr;31(4):666-73)</description><subject>Adult</subject><subject>Aged</subject><subject>Alleles</subject><subject>Apolipoprotein E4</subject><subject>Apolipoproteins E - blood</subject><subject>Apolipoproteins E - genetics</subject><subject>Associated diseases and complications</subject><subject>Biological and medical sciences</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diabetic Nephropathies - blood</subject><subject>Diabetic Nephropathies - etiology</subject><subject>Diabetic Nephropathies - genetics</subject><subject>Disease Progression</subject><subject>DNA - blood</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Female</subject><subject>Genotype</subject><subject>Humans</subject><subject>Kidney Failure, Chronic - blood</subject><subject>Kidney Failure, Chronic - genetics</subject><subject>Kidney Failure, Chronic - therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Phenotype</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Renal Dialysis</subject><subject>Risk Factors</subject><subject>Time Factors</subject><issn>0272-6386</issn><issn>1523-6838</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF1PwyAUhonR6Jz-BCMXxrtOvkrhctn8SpzeeE8o0AzXtRVajf9eljXz0itOOM85vDwAXGM0wyind_pjY2dYSjH7onjWbWVOMRbsCExwTmjGBRXHYIJIQTJOBT8D5zF-IIQk5fwUnI74BKzmXVv7ru1C2zvfwHsGg7ODcREGHzewraD1unS9N7Bx3Tq0ne7XPzChqfCu6SP89v0avj4vl6sLcFLpOrrL8ZyC94f798VT9vL2-LyYv2SGEdZnpSGYElJJREvDbYEplbqQwhApUqo83WLMuGECUctyJgqbW1ZVhGCEEaJTcLtfm1J_Di72auujcXWtG9cOURWy4ERymcBiD5rQxhhcpbrgtzr8KIzUzqPaeVQ7jyp5VAePafJqfGIot84e5v76N2NfR6PrKujG-HjACEHpUzRh8z3mko0v74KKJkkzzvrgTK9s6_-N8gvS0pFx</recordid><startdate>19980401</startdate><enddate>19980401</enddate><creator>Kimura, H</creator><creator>Suzuki, Y</creator><creator>Gejyo, F</creator><creator>Karasawa, R</creator><creator>Miyazaki, R</creator><creator>Suzuki, S</creator><creator>Arakawa, M</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980401</creationdate><title>Apolipoprotein E4 reduces risk of diabetic nephropathy in patients with NIDDM</title><author>Kimura, H ; Suzuki, Y ; Gejyo, F ; Karasawa, R ; Miyazaki, R ; Suzuki, S ; Arakawa, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-bc21322f903bc6d71339a798c29818453bc1146c4803d45487d5d4ff22101003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Alleles</topic><topic>Apolipoprotein E4</topic><topic>Apolipoproteins E - blood</topic><topic>Apolipoproteins E - genetics</topic><topic>Associated diseases and complications</topic><topic>Biological and medical sciences</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Diabetic Nephropathies - blood</topic><topic>Diabetic Nephropathies - etiology</topic><topic>Diabetic Nephropathies - genetics</topic><topic>Disease Progression</topic><topic>DNA - blood</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Female</topic><topic>Genotype</topic><topic>Humans</topic><topic>Kidney Failure, Chronic - blood</topic><topic>Kidney Failure, Chronic - genetics</topic><topic>Kidney Failure, Chronic - therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Phenotype</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Renal Dialysis</topic><topic>Risk Factors</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kimura, H</creatorcontrib><creatorcontrib>Suzuki, Y</creatorcontrib><creatorcontrib>Gejyo, F</creatorcontrib><creatorcontrib>Karasawa, R</creatorcontrib><creatorcontrib>Miyazaki, R</creatorcontrib><creatorcontrib>Suzuki, S</creatorcontrib><creatorcontrib>Arakawa, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of kidney diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kimura, H</au><au>Suzuki, Y</au><au>Gejyo, F</au><au>Karasawa, R</au><au>Miyazaki, R</au><au>Suzuki, S</au><au>Arakawa, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Apolipoprotein E4 reduces risk of diabetic nephropathy in patients with NIDDM</atitle><jtitle>American journal of kidney diseases</jtitle><addtitle>Am J Kidney Dis</addtitle><date>1998-04-01</date><risdate>1998</risdate><volume>31</volume><issue>4</issue><spage>666</spage><epage>673</epage><pages>666-673</pages><issn>0272-6386</issn><eissn>1523-6838</eissn><abstract>Hypercholesterolemia is a major determinant of the decline of renal function in patients with diabetes. Apolipoprotein E polymorphism may influence the metabolism of lipoprotein in diabetic patients. The purpose of this study was to investigate the association between genetic polymorphisms in apolipoprotein E and the progression of diabetic nephropathy in patients with non-insulin-dependent diabetes mellitus over a 10-year period (13 to 37 years; median, 20 years). Subjects with a stable renal function without overt proteinuria had a higher cholesterol level, lower incidences of hypertension and proliferative diabetic retinopathy, and a higher frequency of the E4 allele than subjects with a decline in renal function (end-stage renal failure requiring dialysis treatment). In the diabetic patients, the apolipoprotein E4 carriers had a higher cholesterol level than did the noncarriers. The survival rate from renal disease in the apolipoprotein E4 carriers was higher than in the noncarriers among the diabetic patients. Apolipoprotein E polymorphism and hypertension were identified as independent risk factors for the progression to renal failure. Results indicate that apolipoprotein E polymorphism is associated with the progression of diabetic nephropathy. Presence of the apolipoprotein E4 allele is a protective factor, and other alleles are risk factors. (Am J Kidney Dis 1998 Apr;31(4):666-73)</abstract><cop>Orlando, FL</cop><pub>Elsevier Inc</pub><pmid>9531184</pmid><doi>10.1053/ajkd.1998.v31.pm9531184</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Aged Alleles Apolipoprotein E4 Apolipoproteins E - blood Apolipoproteins E - genetics Associated diseases and complications Biological and medical sciences Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - genetics Diabetes. Impaired glucose tolerance Diabetic Nephropathies - blood Diabetic Nephropathies - etiology Diabetic Nephropathies - genetics Disease Progression DNA - blood Endocrine pancreas. Apud cells (diseases) Endocrinopathies Female Genotype Humans Kidney Failure, Chronic - blood Kidney Failure, Chronic - genetics Kidney Failure, Chronic - therapy Male Medical sciences Middle Aged Phenotype Polymorphism, Genetic - genetics Renal Dialysis Risk Factors Time Factors |
| title | Apolipoprotein E4 reduces risk of diabetic nephropathy in patients with NIDDM |
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