Design, Synthesis, and Evaluation of the Multidrug Resistance-Reversing Activity of d-Glucose Mimetics of Hapalosin

When five substituents of hapalosin were placed on d-glucose, molecular modeling revealed that the substituents on mimetics 2 and 3 occupy similar spatial positions as the corresponding substituents on hapalosin. Mimetic 3 and all the glucopyranoside intermediates generated in its synthesis were ass...

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Veröffentlicht in:	Journal of medicinal chemistry 1998-03, Vol.41 (6), p.981-987
Hauptverfasser:	Dinh, Tam Q, Smith, Charles D, Du, Xiaohui, Armstrong, Robert W
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents ATP-Binding Cassette Transporters - antagonists & inhibitors ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors Biological and medical sciences Cell Survival - drug effects Depsipeptides Drug Design Drug Resistance, Multiple Drug Resistance, Neoplasm General aspects Glucose - chemistry Humans Lactams - chemical synthesis Lactams - pharmacology Lactones - chemical synthesis Lactones - pharmacology Medical sciences Molecular Mimicry Multidrug Resistance-Associated Proteins Pharmacology. Drug treatments Tumor Cells, Cultured
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