Sustained Cognitive Decline in HIV Infection: Relationship to CD4+ Cell Count, Plasma Viremia and p24 Antigenemia
To determine the clinical and virological correlates of neuropsychological test performance decline in HIV infection, we measured viral burden in blood in 272 HIV-seropositive men without dementia in the Baltimore arm of the Multicenter AIDS Cohort Study (MACS). These measures were then related to n...
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Veröffentlicht in: | Journal of neurovirology 1998-02, Vol.4 (1), p.95-99 |
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creator | Dal Pan, Gerald J Farzadegan, Homayoon Seines, Ola Hoover, Donald R Miller, Eric N Skolasky, Richard L Nance-Sproson, Tish E McArthur, Justin C |
description | To determine the clinical and virological correlates of neuropsychological test performance decline in HIV infection, we measured viral burden in blood in 272 HIV-seropositive men without dementia in the Baltimore arm of the Multicenter AIDS Cohort Study (MACS). These measures were then related to neuropsychological (NP) decline, defined as a decline relative to prior best performance of 2.0 standard deviations or more on one or more neuropsychological tests. A short battery of NP tests (Mini-Screen Battery) was administered to all 272 men. NP test performance decline was identified in 53/272 (19.5%) of participants on the Mini-Screen Battery. Follow-up NP data were available for 204 participants who had undergone the Mini-Screen. The frequency of sustained NP test performance decline was 7.8% for the Mini-Screen Battery. A lower CD4+ cell count was weakly associated with sustained NP test performance decline. After adjustment for CD4+ cell count, hemoglobin, body mass index, and presence of AIDS, none of the viral burden measures (p24 antigenemia, plasma viremia, quantitative culture) correlated with sustained NP test performance decline. We conclude that these measures of blood HIV viral burden are not markers for NP decline, but that a lower CD4+ cell count is. |
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These measures were then related to neuropsychological (NP) decline, defined as a decline relative to prior best performance of 2.0 standard deviations or more on one or more neuropsychological tests. A short battery of NP tests (Mini-Screen Battery) was administered to all 272 men. NP test performance decline was identified in 53/272 (19.5%) of participants on the Mini-Screen Battery. Follow-up NP data were available for 204 participants who had undergone the Mini-Screen. The frequency of sustained NP test performance decline was 7.8% for the Mini-Screen Battery. A lower CD4+ cell count was weakly associated with sustained NP test performance decline. After adjustment for CD4+ cell count, hemoglobin, body mass index, and presence of AIDS, none of the viral burden measures (p24 antigenemia, plasma viremia, quantitative culture) correlated with sustained NP test performance decline. We conclude that these measures of blood HIV viral burden are not markers for NP decline, but that a lower CD4+ cell count is.</description><identifier>ISSN: 1355-0284</identifier><identifier>EISSN: 1538-2443</identifier><identifier>DOI: 10.3109/13550289809113486</identifier><identifier>PMID: 9531016</identifier><language>eng</language><publisher>United States: Informa UK Ltd</publisher><subject>Adult ; AIDS Dementia Complex - drug therapy ; AIDS Dementia Complex - immunology ; AIDS Dementia Complex - virology ; AIDS/HIV ; Antiviral Agents - administration & dosage ; CD4 Lymphocyte Count ; CD4-Positive T-Lymphocytes ; HIV Core Protein p24 - blood ; HIV Core Protein p24 - isolation & purification ; HIV-1 ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Viremia - drug therapy ; Viremia - immunology ; Viremia - virology ; Zidovudine - administration & dosage</subject><ispartof>Journal of neurovirology, 1998-02, Vol.4 (1), p.95-99</ispartof><rights>1998 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1998</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c379t-b13b655b82537294d689033bdb438baf46e63c4f4610a288cd8dce6f32de25443</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/13550289809113486$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/13550289809113486$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>315,781,785,27928,27929,61225,61406</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9531016$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dal Pan, Gerald J</creatorcontrib><creatorcontrib>Farzadegan, Homayoon</creatorcontrib><creatorcontrib>Seines, Ola</creatorcontrib><creatorcontrib>Hoover, Donald R</creatorcontrib><creatorcontrib>Miller, Eric N</creatorcontrib><creatorcontrib>Skolasky, Richard L</creatorcontrib><creatorcontrib>Nance-Sproson, Tish E</creatorcontrib><creatorcontrib>McArthur, Justin C</creatorcontrib><title>Sustained Cognitive Decline in HIV Infection: Relationship to CD4+ Cell Count, Plasma Viremia and p24 Antigenemia</title><title>Journal of neurovirology</title><addtitle>J Neurovirol</addtitle><description>To determine the clinical and virological correlates of neuropsychological test performance decline in HIV infection, we measured viral burden in blood in 272 HIV-seropositive men without dementia in the Baltimore arm of the Multicenter AIDS Cohort Study (MACS). These measures were then related to neuropsychological (NP) decline, defined as a decline relative to prior best performance of 2.0 standard deviations or more on one or more neuropsychological tests. A short battery of NP tests (Mini-Screen Battery) was administered to all 272 men. NP test performance decline was identified in 53/272 (19.5%) of participants on the Mini-Screen Battery. Follow-up NP data were available for 204 participants who had undergone the Mini-Screen. The frequency of sustained NP test performance decline was 7.8% for the Mini-Screen Battery. A lower CD4+ cell count was weakly associated with sustained NP test performance decline. After adjustment for CD4+ cell count, hemoglobin, body mass index, and presence of AIDS, none of the viral burden measures (p24 antigenemia, plasma viremia, quantitative culture) correlated with sustained NP test performance decline. We conclude that these measures of blood HIV viral burden are not markers for NP decline, but that a lower CD4+ cell count is.</description><subject>Adult</subject><subject>AIDS Dementia Complex - drug therapy</subject><subject>AIDS Dementia Complex - immunology</subject><subject>AIDS Dementia Complex - virology</subject><subject>AIDS/HIV</subject><subject>Antiviral Agents - administration & dosage</subject><subject>CD4 Lymphocyte Count</subject><subject>CD4-Positive T-Lymphocytes</subject><subject>HIV Core Protein p24 - blood</subject><subject>HIV Core Protein p24 - isolation & purification</subject><subject>HIV-1</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Viremia - drug therapy</subject><subject>Viremia - immunology</subject><subject>Viremia - virology</subject><subject>Zidovudine - administration & dosage</subject><issn>1355-0284</issn><issn>1538-2443</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUUtv1DAQthCo9PUDOCD5xAUCfseGU5UWulKlVn1dI8eZdF0lztZ2kPj3eLUrLkhwmtF8D3vmQ-gdJZ85JeYL5VISpo0mhlIutHqFDqnkumJC8NelL3hVCOItOkrpmRDKFdMH6MDIoqfqEL3cLSlbH6DHzfwUfPY_AZ-DG8sI-4AvV494FQZw2c_hK76F0W67tPYbnGfcnIuPuIFxLOol5E_4ZrRpsvjRR5i8xTb0eMMEPgvZP0HYzk7Qm8GOCU739Rg9fL-4by6rq-sfq-bsqnK8NrnqKO-UlJ1mktfMiF5pQzjv-k5w3dlBKFDciVIpsUxr1-vegRo464HJsv4x-rDz3cT5ZYGU28knV75qA8xLamtTK2pY_V8iVeVFKUwh0h3RxTmlCEO7iX6y8VdLSbvNo_0rj6J5vzdfugn6P4p9AAX_tsN9GOY42TXYMa-djdA-z0sM5UL_cP8Ng9yV6g</recordid><startdate>19980201</startdate><enddate>19980201</enddate><creator>Dal Pan, Gerald J</creator><creator>Farzadegan, Homayoon</creator><creator>Seines, Ola</creator><creator>Hoover, Donald R</creator><creator>Miller, Eric N</creator><creator>Skolasky, Richard L</creator><creator>Nance-Sproson, Tish E</creator><creator>McArthur, Justin C</creator><general>Informa UK Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19980201</creationdate><title>Sustained Cognitive Decline in HIV Infection: Relationship to CD4+ Cell Count, Plasma Viremia and p24 Antigenemia</title><author>Dal Pan, Gerald J ; Farzadegan, Homayoon ; Seines, Ola ; Hoover, Donald R ; Miller, Eric N ; Skolasky, Richard L ; Nance-Sproson, Tish E ; McArthur, Justin C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c379t-b13b655b82537294d689033bdb438baf46e63c4f4610a288cd8dce6f32de25443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>AIDS Dementia Complex - drug therapy</topic><topic>AIDS Dementia Complex - immunology</topic><topic>AIDS Dementia Complex - virology</topic><topic>AIDS/HIV</topic><topic>Antiviral Agents - administration & dosage</topic><topic>CD4 Lymphocyte Count</topic><topic>CD4-Positive T-Lymphocytes</topic><topic>HIV Core Protein p24 - blood</topic><topic>HIV Core Protein p24 - isolation & purification</topic><topic>HIV-1</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Viremia - drug therapy</topic><topic>Viremia - immunology</topic><topic>Viremia - virology</topic><topic>Zidovudine - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dal Pan, Gerald J</creatorcontrib><creatorcontrib>Farzadegan, Homayoon</creatorcontrib><creatorcontrib>Seines, Ola</creatorcontrib><creatorcontrib>Hoover, Donald R</creatorcontrib><creatorcontrib>Miller, Eric N</creatorcontrib><creatorcontrib>Skolasky, Richard L</creatorcontrib><creatorcontrib>Nance-Sproson, Tish E</creatorcontrib><creatorcontrib>McArthur, Justin C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurovirology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dal Pan, Gerald J</au><au>Farzadegan, Homayoon</au><au>Seines, Ola</au><au>Hoover, Donald R</au><au>Miller, Eric N</au><au>Skolasky, Richard L</au><au>Nance-Sproson, Tish E</au><au>McArthur, Justin C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sustained Cognitive Decline in HIV Infection: Relationship to CD4+ Cell Count, Plasma Viremia and p24 Antigenemia</atitle><jtitle>Journal of neurovirology</jtitle><addtitle>J Neurovirol</addtitle><date>1998-02-01</date><risdate>1998</risdate><volume>4</volume><issue>1</issue><spage>95</spage><epage>99</epage><pages>95-99</pages><issn>1355-0284</issn><eissn>1538-2443</eissn><abstract>To determine the clinical and virological correlates of neuropsychological test performance decline in HIV infection, we measured viral burden in blood in 272 HIV-seropositive men without dementia in the Baltimore arm of the Multicenter AIDS Cohort Study (MACS). These measures were then related to neuropsychological (NP) decline, defined as a decline relative to prior best performance of 2.0 standard deviations or more on one or more neuropsychological tests. A short battery of NP tests (Mini-Screen Battery) was administered to all 272 men. NP test performance decline was identified in 53/272 (19.5%) of participants on the Mini-Screen Battery. Follow-up NP data were available for 204 participants who had undergone the Mini-Screen. The frequency of sustained NP test performance decline was 7.8% for the Mini-Screen Battery. A lower CD4+ cell count was weakly associated with sustained NP test performance decline. After adjustment for CD4+ cell count, hemoglobin, body mass index, and presence of AIDS, none of the viral burden measures (p24 antigenemia, plasma viremia, quantitative culture) correlated with sustained NP test performance decline. 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subjects | Adult AIDS Dementia Complex - drug therapy AIDS Dementia Complex - immunology AIDS Dementia Complex - virology AIDS/HIV Antiviral Agents - administration & dosage CD4 Lymphocyte Count CD4-Positive T-Lymphocytes HIV Core Protein p24 - blood HIV Core Protein p24 - isolation & purification HIV-1 Humans Longitudinal Studies Male Middle Aged Viremia - drug therapy Viremia - immunology Viremia - virology Zidovudine - administration & dosage |
title | Sustained Cognitive Decline in HIV Infection: Relationship to CD4+ Cell Count, Plasma Viremia and p24 Antigenemia |
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