Sustained Cognitive Decline in HIV Infection: Relationship to CD4+ Cell Count, Plasma Viremia and p24 Antigenemia

To determine the clinical and virological correlates of neuropsychological test performance decline in HIV infection, we measured viral burden in blood in 272 HIV-seropositive men without dementia in the Baltimore arm of the Multicenter AIDS Cohort Study (MACS). These measures were then related to n...

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Veröffentlicht in:Journal of neurovirology 1998-02, Vol.4 (1), p.95-99
Hauptverfasser: Dal Pan, Gerald J, Farzadegan, Homayoon, Seines, Ola, Hoover, Donald R, Miller, Eric N, Skolasky, Richard L, Nance-Sproson, Tish E, McArthur, Justin C
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container_end_page 99
container_issue 1
container_start_page 95
container_title Journal of neurovirology
container_volume 4
creator Dal Pan, Gerald J
Farzadegan, Homayoon
Seines, Ola
Hoover, Donald R
Miller, Eric N
Skolasky, Richard L
Nance-Sproson, Tish E
McArthur, Justin C
description To determine the clinical and virological correlates of neuropsychological test performance decline in HIV infection, we measured viral burden in blood in 272 HIV-seropositive men without dementia in the Baltimore arm of the Multicenter AIDS Cohort Study (MACS). These measures were then related to neuropsychological (NP) decline, defined as a decline relative to prior best performance of 2.0 standard deviations or more on one or more neuropsychological tests. A short battery of NP tests (Mini-Screen Battery) was administered to all 272 men. NP test performance decline was identified in 53/272 (19.5%) of participants on the Mini-Screen Battery. Follow-up NP data were available for 204 participants who had undergone the Mini-Screen. The frequency of sustained NP test performance decline was 7.8% for the Mini-Screen Battery. A lower CD4+ cell count was weakly associated with sustained NP test performance decline. After adjustment for CD4+ cell count, hemoglobin, body mass index, and presence of AIDS, none of the viral burden measures (p24 antigenemia, plasma viremia, quantitative culture) correlated with sustained NP test performance decline. We conclude that these measures of blood HIV viral burden are not markers for NP decline, but that a lower CD4+ cell count is.
doi_str_mv 10.3109/13550289809113486
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source MEDLINE; Taylor & Francis:Master (3349 titles); EZB-FREE-00999 freely available EZB journals
subjects Adult
AIDS Dementia Complex - drug therapy
AIDS Dementia Complex - immunology
AIDS Dementia Complex - virology
AIDS/HIV
Antiviral Agents - administration & dosage
CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes
HIV Core Protein p24 - blood
HIV Core Protein p24 - isolation & purification
HIV-1
Humans
Longitudinal Studies
Male
Middle Aged
Viremia - drug therapy
Viremia - immunology
Viremia - virology
Zidovudine - administration & dosage
title Sustained Cognitive Decline in HIV Infection: Relationship to CD4+ Cell Count, Plasma Viremia and p24 Antigenemia
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