Phosphorothioate analogs of (2'-5')(A)4: agonist and antagonist activities in intact cells

Metabolically stable phosphorothioate tetramer analogues of (2'-5')(A)n with Rp and/or Sp chirality in the 2'-5'-phosphodiester linkages constitute a new class of antiviral agents since they mimic the effects of interferons. Three of the diastereomeric 5'-monophosphates (i.e...

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Veröffentlicht in:	Biochemistry (Easton) 1990-03, Vol.29 (10), p.2550-2556
Hauptverfasser:	Charachon, Guillaume, Sobol, Robert W, Bisbal, Catherine, Salehzada, Tamim, Silhol, Michele, Charubala, Ramamurthy, Pfleiderer, Wolfgang, Lebleu, Bernard, Suhadolnik, Robert J
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Antiviral Agents - pharmacology Biological and medical sciences Chemical Phenomena Chemistry Endoribonucleases - antagonists & inhibitors Enzyme Activation HeLa Cells Humans Kinetics Medical sciences Nucleic Acid Denaturation Organothiophosphorus Compounds - pharmacology Pharmacology. Drug treatments Phosphorylation Polynucleotide 5'-Hydroxyl-Kinase - metabolism RNA, Ribosomal - drug effects RNA, Ribosomal - isolation & purification Vesicular stomatitis Indiana virus - drug effects Vesicular stomatitis Indiana virus - enzymology Vesicular stomatitis Indiana virus - growth & development Virus Replication - drug effects
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