Aqueous humor interleukin-6 levels in uveitis
The level of Interleukin-6 (IL-6) in the aqueous humor of 24 patients with 2 types of uveitis was measured with a specific bioassay using the murine hybridoma cell line B9. Sixteen patients had Fuchs' heterochromic cyclitis (FHC) and 8 had toxoplasma uveitis (TU). Sixty-three percent of each of...
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| Veröffentlicht in: | Investigative ophthalmology & visual science 1990-05, Vol.31 (5), p.917-920 |
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| container_title | Investigative ophthalmology & visual science |
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| creator | Murray, PI Hoekzema, R van Haren, MA de Hon, FD Kijlstra, A |
| description | The level of Interleukin-6 (IL-6) in the aqueous humor of 24 patients with 2 types of uveitis was measured with a specific bioassay using the murine hybridoma cell line B9. Sixteen patients had Fuchs' heterochromic cyclitis (FHC) and 8 had toxoplasma uveitis (TU). Sixty-three percent of each of the FHC and TU groups had raised levels of IL-6 in their aqueous (mean: 543 and 19,228 units/ml respectively). Thirteen control aqueous samples, obtained at surgery for senile cataract, showed IL-6 levels of less than 10 units/ml. Serum obtained at the same time as each aqueous humor sample also showed IL-6 levels of less than 10 units/ml, indicating that the raised levels of IL-6 found in the aqueous of uveitis patients did not result from serum leakage, but from local production. This is the first report on intraocular IL-6 levels, and indicates that IL-6 may play a role as an inflammatory mediator in uveitis. |
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Sixteen patients had Fuchs' heterochromic cyclitis (FHC) and 8 had toxoplasma uveitis (TU). Sixty-three percent of each of the FHC and TU groups had raised levels of IL-6 in their aqueous (mean: 543 and 19,228 units/ml respectively). Thirteen control aqueous samples, obtained at surgery for senile cataract, showed IL-6 levels of less than 10 units/ml. Serum obtained at the same time as each aqueous humor sample also showed IL-6 levels of less than 10 units/ml, indicating that the raised levels of IL-6 found in the aqueous of uveitis patients did not result from serum leakage, but from local production. This is the first report on intraocular IL-6 levels, and indicates that IL-6 may play a role as an inflammatory mediator in uveitis.</description><identifier>ISSN: 0146-0404</identifier><identifier>EISSN: 1552-5783</identifier><identifier>PMID: 2335453</identifier><identifier>CODEN: IOVSDA</identifier><language>eng</language><publisher>Rockville, MD: ARVO</publisher><subject>Adolescent ; Adult ; Aged ; Aqueous Humor - metabolism ; Biological and medical sciences ; Biological Assay ; Female ; Humans ; Interleukin-6 - metabolism ; Iridocyclitis - metabolism ; Male ; Medical sciences ; Middle Aged ; Ophthalmology ; Toxoplasmosis, Ocular - complications ; Uvea diseases ; Uveitis - etiology ; Uveitis - metabolism ; Uveitis, Posterior - metabolism</subject><ispartof>Investigative ophthalmology & visual science, 1990-05, Vol.31 (5), p.917-920</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19725066$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2335453$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Murray, PI</creatorcontrib><creatorcontrib>Hoekzema, R</creatorcontrib><creatorcontrib>van Haren, MA</creatorcontrib><creatorcontrib>de Hon, FD</creatorcontrib><creatorcontrib>Kijlstra, A</creatorcontrib><title>Aqueous humor interleukin-6 levels in uveitis</title><title>Investigative ophthalmology & visual science</title><addtitle>Invest Ophthalmol Vis Sci</addtitle><description>The level of Interleukin-6 (IL-6) in the aqueous humor of 24 patients with 2 types of uveitis was measured with a specific bioassay using the murine hybridoma cell line B9. Sixteen patients had Fuchs' heterochromic cyclitis (FHC) and 8 had toxoplasma uveitis (TU). Sixty-three percent of each of the FHC and TU groups had raised levels of IL-6 in their aqueous (mean: 543 and 19,228 units/ml respectively). Thirteen control aqueous samples, obtained at surgery for senile cataract, showed IL-6 levels of less than 10 units/ml. Serum obtained at the same time as each aqueous humor sample also showed IL-6 levels of less than 10 units/ml, indicating that the raised levels of IL-6 found in the aqueous of uveitis patients did not result from serum leakage, but from local production. This is the first report on intraocular IL-6 levels, and indicates that IL-6 may play a role as an inflammatory mediator in uveitis.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aqueous Humor - metabolism</subject><subject>Biological and medical sciences</subject><subject>Biological Assay</subject><subject>Female</subject><subject>Humans</subject><subject>Interleukin-6 - metabolism</subject><subject>Iridocyclitis - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Ophthalmology</subject><subject>Toxoplasmosis, Ocular - complications</subject><subject>Uvea diseases</subject><subject>Uveitis - etiology</subject><subject>Uveitis - metabolism</subject><subject>Uveitis, Posterior - metabolism</subject><issn>0146-0404</issn><issn>1552-5783</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEYhIMotVZ_grAXvQXync2xFLVCwYueQ5K-daPZbd3sdvHfu-KiR08DMw_DMCdoTqVkWOqSn6I5oUJhIog4Rxc5vxHCKGVkhmaMcykknyO8_Ohh3-ei6ut9W8SmgzZB_x4brIoER0h5NIv-CLGL-RKd7VzKcDXpAr3c3z2v1njz9PC4Wm5wxYzucOmCMEIZZjxlvAzea02C0NR4BUpLCkBYObp8y6jhzDsIHlTYkaBcYJov0O1P76Hdj_tyZ-uYA6Tkmu-xVhstS27EvyCVpiyVkSN4PYG9r2FrD22sXftppyPG_GbKXQ4u7VrXhJh_MWo0k0SpP66Kr9UQW7C5dimNrdQOw8CpldZQzb8AbXVzNQ</recordid><startdate>19900501</startdate><enddate>19900501</enddate><creator>Murray, PI</creator><creator>Hoekzema, R</creator><creator>van Haren, MA</creator><creator>de Hon, FD</creator><creator>Kijlstra, A</creator><general>ARVO</general><general>Association for Research in Vision and Ophtalmology</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19900501</creationdate><title>Aqueous humor interleukin-6 levels in uveitis</title><author>Murray, PI ; Hoekzema, R ; van Haren, MA ; de Hon, FD ; Kijlstra, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h297t-8ac4946929b1238cbb770c4719b6e6751ee028bb73d21932baecbe6cf0c6ac273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aqueous Humor - metabolism</topic><topic>Biological and medical sciences</topic><topic>Biological Assay</topic><topic>Female</topic><topic>Humans</topic><topic>Interleukin-6 - metabolism</topic><topic>Iridocyclitis - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Ophthalmology</topic><topic>Toxoplasmosis, Ocular - complications</topic><topic>Uvea diseases</topic><topic>Uveitis - etiology</topic><topic>Uveitis - metabolism</topic><topic>Uveitis, Posterior - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Murray, PI</creatorcontrib><creatorcontrib>Hoekzema, R</creatorcontrib><creatorcontrib>van Haren, MA</creatorcontrib><creatorcontrib>de Hon, FD</creatorcontrib><creatorcontrib>Kijlstra, A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Investigative ophthalmology & visual science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Murray, PI</au><au>Hoekzema, R</au><au>van Haren, MA</au><au>de Hon, FD</au><au>Kijlstra, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aqueous humor interleukin-6 levels in uveitis</atitle><jtitle>Investigative ophthalmology & visual science</jtitle><addtitle>Invest Ophthalmol Vis Sci</addtitle><date>1990-05-01</date><risdate>1990</risdate><volume>31</volume><issue>5</issue><spage>917</spage><epage>920</epage><pages>917-920</pages><issn>0146-0404</issn><eissn>1552-5783</eissn><coden>IOVSDA</coden><abstract>The level of Interleukin-6 (IL-6) in the aqueous humor of 24 patients with 2 types of uveitis was measured with a specific bioassay using the murine hybridoma cell line B9. Sixteen patients had Fuchs' heterochromic cyclitis (FHC) and 8 had toxoplasma uveitis (TU). Sixty-three percent of each of the FHC and TU groups had raised levels of IL-6 in their aqueous (mean: 543 and 19,228 units/ml respectively). Thirteen control aqueous samples, obtained at surgery for senile cataract, showed IL-6 levels of less than 10 units/ml. Serum obtained at the same time as each aqueous humor sample also showed IL-6 levels of less than 10 units/ml, indicating that the raised levels of IL-6 found in the aqueous of uveitis patients did not result from serum leakage, but from local production. This is the first report on intraocular IL-6 levels, and indicates that IL-6 may play a role as an inflammatory mediator in uveitis.</abstract><cop>Rockville, MD</cop><pub>ARVO</pub><pmid>2335453</pmid><tpages>4</tpages></addata></record> |
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| ispartof | Investigative ophthalmology & visual science, 1990-05, Vol.31 (5), p.917-920 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Adult Aged Aqueous Humor - metabolism Biological and medical sciences Biological Assay Female Humans Interleukin-6 - metabolism Iridocyclitis - metabolism Male Medical sciences Middle Aged Ophthalmology Toxoplasmosis, Ocular - complications Uvea diseases Uveitis - etiology Uveitis - metabolism Uveitis, Posterior - metabolism |
| title | Aqueous humor interleukin-6 levels in uveitis |
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