Effect of ginseng saponins on exercise performance in non-trained rats
Abstract Short term (4 days), but not acute, treatment with ginseng saponin (GS, 10 and 20 mg/kg/day) significantly prolonged the aerobic endurance of non-trained rats exercising at approximately 70% VO 2 max. Compared to the saline controls, GS treatment significantly increased the plasma free fatt...
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| Veröffentlicht in: | Planta medica 1998-03, Vol.64 (2), p.130-133 |
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| creator | Wang, L.C.H Lee, T |
| description | Abstract
Short term (4 days), but not acute, treatment with ginseng saponin (GS, 10 and 20 mg/kg/day) significantly prolonged the aerobic endurance of non-trained rats exercising at approximately 70% VO
2
max. Compared to the saline controls, GS treatment significantly increased the plasma free fatty acid (FFA) level and maintained plasma glucose level during exercise. Both the liver and skeletal muscle glycogen levels of the GS-treated rats were slightly higher than those of saline-treated controls after exhaustive exercise. These results indicate that GS enhances exercise endurance by altering fuel homeostasis during prolonged exercise, presumably by increasing FFA utilization in preference over glucose for cellular energy demands. To further search for the active components responsible for the ergogenic effect of GS, it was found that a GS preparation devoid of Rg
1
and Rb
1
failed, whereas injection of either Rg
1
or Rb
1
enhanced aerobic exercise performance. These results indicate that both Rg
1
and Rb
1
are key ingredients in GS-mediated enhancement in aerobic endurance. |
| doi_str_mv | 10.1055/s-2006-957389 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_79757098</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>79757098</sourcerecordid><originalsourceid>FETCH-LOGICAL-c444t-ade841bfcb3b7634007c6993580287babe20ba0f8c9efa590e06a51a687f2f3b3</originalsourceid><addsrcrecordid>eNp1kM9LHTEUhUOp6Kvt0qWYhbhq7M2vyWRZRFtB6KK6Dpm8m-fIm-SZzIP2v29kHu66ugfOx7nwEXLG4ZqD1t8qEwAds9rI3n4gK66kZSAE_0hWAFIwsEqekE-1vgBwZQGOybHVQnNQK3J3GyOGmeZIN2OqmDa0-l1OLdOcKP7BEsaKdIcl5jL5FJCOiaac2Fz8mHBNi5_rZ3IU_bbil8M9JU93t483P9nDrx_3N98fWFBKzcyvsVd8iGGQg-mkAjChs1bqHkRvBj-ggMFD7IPF6LUFhM5r7rveRBHlIE_J1bK7K_l1j3V201gDbrc-Yd5XZ6zRBmzfQLaAoeRaC0a3K-Pky1_Hwb15c9W9eXOLt8afH4b3w4Trd_ogqvWXh97X4LexNBNjfccEN1x3omFfF2x-HnFC95L3JTUh__16seDRZ-c3pS0-_RbAZdPRQ2c7-Q--R4u0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>79757098</pqid></control><display><type>article</type><title>Effect of ginseng saponins on exercise performance in non-trained rats</title><source>MEDLINE</source><source>Thieme Connect Journals</source><creator>Wang, L.C.H ; Lee, T</creator><creatorcontrib>Wang, L.C.H ; Lee, T</creatorcontrib><description>Abstract
Short term (4 days), but not acute, treatment with ginseng saponin (GS, 10 and 20 mg/kg/day) significantly prolonged the aerobic endurance of non-trained rats exercising at approximately 70% VO
2
max. Compared to the saline controls, GS treatment significantly increased the plasma free fatty acid (FFA) level and maintained plasma glucose level during exercise. Both the liver and skeletal muscle glycogen levels of the GS-treated rats were slightly higher than those of saline-treated controls after exhaustive exercise. These results indicate that GS enhances exercise endurance by altering fuel homeostasis during prolonged exercise, presumably by increasing FFA utilization in preference over glucose for cellular energy demands. To further search for the active components responsible for the ergogenic effect of GS, it was found that a GS preparation devoid of Rg
1
and Rb
1
failed, whereas injection of either Rg
1
or Rb
1
enhanced aerobic exercise performance. These results indicate that both Rg
1
and Rb
1
are key ingredients in GS-mediated enhancement in aerobic endurance.</description><identifier>ISSN: 0032-0943</identifier><identifier>EISSN: 1439-0221</identifier><identifier>DOI: 10.1055/s-2006-957389</identifier><identifier>PMID: 9525104</identifier><identifier>CODEN: PLMEAA</identifier><language>eng</language><publisher>Stuttgart: Thieme</publisher><subject>Animals ; Biological and medical sciences ; Blood Glucose - metabolism ; blood plasma ; Central Nervous System Agents - pharmacology ; chemical composition ; endurance ; exercise ; fatty acids ; Fatty Acids, Nonesterified - blood ; General pharmacology ; Ginsenosides ; glucose ; glycogen ; Glycogen - metabolism ; homeostasis ; Lactates - metabolism ; lactic acid ; liver ; Liver Glycogen - metabolism ; Male ; Medical sciences ; Muscle, Skeletal - drug effects ; Muscle, Skeletal - metabolism ; Oxygen Consumption ; Panax ; Panax quinquefolius ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Physical Conditioning, Animal - physiology ; Physical Exertion - drug effects ; Plants, Medicinal ; Rats ; Rats, Sprague-Dawley ; saponins ; Saponins - pharmacology ; skeletal muscle ; Space life sciences</subject><ispartof>Planta medica, 1998-03, Vol.64 (2), p.130-133</ispartof><rights>Georg Thieme Verlag Stuttgart · New York</rights><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-ade841bfcb3b7634007c6993580287babe20ba0f8c9efa590e06a51a687f2f3b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2006-957389.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><link.rule.ids>314,777,781,3004,3005,27905,27906,54540</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2171562$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9525104$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, L.C.H</creatorcontrib><creatorcontrib>Lee, T</creatorcontrib><title>Effect of ginseng saponins on exercise performance in non-trained rats</title><title>Planta medica</title><addtitle>Planta Med</addtitle><description>Abstract
Short term (4 days), but not acute, treatment with ginseng saponin (GS, 10 and 20 mg/kg/day) significantly prolonged the aerobic endurance of non-trained rats exercising at approximately 70% VO
2
max. Compared to the saline controls, GS treatment significantly increased the plasma free fatty acid (FFA) level and maintained plasma glucose level during exercise. Both the liver and skeletal muscle glycogen levels of the GS-treated rats were slightly higher than those of saline-treated controls after exhaustive exercise. These results indicate that GS enhances exercise endurance by altering fuel homeostasis during prolonged exercise, presumably by increasing FFA utilization in preference over glucose for cellular energy demands. To further search for the active components responsible for the ergogenic effect of GS, it was found that a GS preparation devoid of Rg
1
and Rb
1
failed, whereas injection of either Rg
1
or Rb
1
enhanced aerobic exercise performance. These results indicate that both Rg
1
and Rb
1
are key ingredients in GS-mediated enhancement in aerobic endurance.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>blood plasma</subject><subject>Central Nervous System Agents - pharmacology</subject><subject>chemical composition</subject><subject>endurance</subject><subject>exercise</subject><subject>fatty acids</subject><subject>Fatty Acids, Nonesterified - blood</subject><subject>General pharmacology</subject><subject>Ginsenosides</subject><subject>glucose</subject><subject>glycogen</subject><subject>Glycogen - metabolism</subject><subject>homeostasis</subject><subject>Lactates - metabolism</subject><subject>lactic acid</subject><subject>liver</subject><subject>Liver Glycogen - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Muscle, Skeletal - drug effects</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Oxygen Consumption</subject><subject>Panax</subject><subject>Panax quinquefolius</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Physical Conditioning, Animal - physiology</subject><subject>Physical Exertion - drug effects</subject><subject>Plants, Medicinal</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>saponins</subject><subject>Saponins - pharmacology</subject><subject>skeletal muscle</subject><subject>Space life sciences</subject><issn>0032-0943</issn><issn>1439-0221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM9LHTEUhUOp6Kvt0qWYhbhq7M2vyWRZRFtB6KK6Dpm8m-fIm-SZzIP2v29kHu66ugfOx7nwEXLG4ZqD1t8qEwAds9rI3n4gK66kZSAE_0hWAFIwsEqekE-1vgBwZQGOybHVQnNQK3J3GyOGmeZIN2OqmDa0-l1OLdOcKP7BEsaKdIcl5jL5FJCOiaac2Fz8mHBNi5_rZ3IU_bbil8M9JU93t483P9nDrx_3N98fWFBKzcyvsVd8iGGQg-mkAjChs1bqHkRvBj-ggMFD7IPF6LUFhM5r7rveRBHlIE_J1bK7K_l1j3V201gDbrc-Yd5XZ6zRBmzfQLaAoeRaC0a3K-Pky1_Hwb15c9W9eXOLt8afH4b3w4Trd_ogqvWXh97X4LexNBNjfccEN1x3omFfF2x-HnFC95L3JTUh__16seDRZ-c3pS0-_RbAZdPRQ2c7-Q--R4u0</recordid><startdate>19980301</startdate><enddate>19980301</enddate><creator>Wang, L.C.H</creator><creator>Lee, T</creator><general>Thieme</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19980301</creationdate><title>Effect of ginseng saponins on exercise performance in non-trained rats</title><author>Wang, L.C.H ; Lee, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-ade841bfcb3b7634007c6993580287babe20ba0f8c9efa590e06a51a687f2f3b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>blood plasma</topic><topic>Central Nervous System Agents - pharmacology</topic><topic>chemical composition</topic><topic>endurance</topic><topic>exercise</topic><topic>fatty acids</topic><topic>Fatty Acids, Nonesterified - blood</topic><topic>General pharmacology</topic><topic>Ginsenosides</topic><topic>glucose</topic><topic>glycogen</topic><topic>Glycogen - metabolism</topic><topic>homeostasis</topic><topic>Lactates - metabolism</topic><topic>lactic acid</topic><topic>liver</topic><topic>Liver Glycogen - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Muscle, Skeletal - drug effects</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Oxygen Consumption</topic><topic>Panax</topic><topic>Panax quinquefolius</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Physical Conditioning, Animal - physiology</topic><topic>Physical Exertion - drug effects</topic><topic>Plants, Medicinal</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>saponins</topic><topic>Saponins - pharmacology</topic><topic>skeletal muscle</topic><topic>Space life sciences</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, L.C.H</creatorcontrib><creatorcontrib>Lee, T</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Planta medica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, L.C.H</au><au>Lee, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of ginseng saponins on exercise performance in non-trained rats</atitle><jtitle>Planta medica</jtitle><addtitle>Planta Med</addtitle><date>1998-03-01</date><risdate>1998</risdate><volume>64</volume><issue>2</issue><spage>130</spage><epage>133</epage><pages>130-133</pages><issn>0032-0943</issn><eissn>1439-0221</eissn><coden>PLMEAA</coden><abstract>Abstract
Short term (4 days), but not acute, treatment with ginseng saponin (GS, 10 and 20 mg/kg/day) significantly prolonged the aerobic endurance of non-trained rats exercising at approximately 70% VO
2
max. Compared to the saline controls, GS treatment significantly increased the plasma free fatty acid (FFA) level and maintained plasma glucose level during exercise. Both the liver and skeletal muscle glycogen levels of the GS-treated rats were slightly higher than those of saline-treated controls after exhaustive exercise. These results indicate that GS enhances exercise endurance by altering fuel homeostasis during prolonged exercise, presumably by increasing FFA utilization in preference over glucose for cellular energy demands. To further search for the active components responsible for the ergogenic effect of GS, it was found that a GS preparation devoid of Rg
1
and Rb
1
failed, whereas injection of either Rg
1
or Rb
1
enhanced aerobic exercise performance. These results indicate that both Rg
1
and Rb
1
are key ingredients in GS-mediated enhancement in aerobic endurance.</abstract><cop>Stuttgart</cop><cop>New York, NY</cop><pub>Thieme</pub><pmid>9525104</pmid><doi>10.1055/s-2006-957389</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Thieme Connect Journals |
| subjects | Animals Biological and medical sciences Blood Glucose - metabolism blood plasma Central Nervous System Agents - pharmacology chemical composition endurance exercise fatty acids Fatty Acids, Nonesterified - blood General pharmacology Ginsenosides glucose glycogen Glycogen - metabolism homeostasis Lactates - metabolism lactic acid liver Liver Glycogen - metabolism Male Medical sciences Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Oxygen Consumption Panax Panax quinquefolius Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Physical Conditioning, Animal - physiology Physical Exertion - drug effects Plants, Medicinal Rats Rats, Sprague-Dawley saponins Saponins - pharmacology skeletal muscle Space life sciences |
| title | Effect of ginseng saponins on exercise performance in non-trained rats |
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