Serum Triglycerides and Clinical Benefit in Lipid-Lowering Trials
Trial evidence shows that effective lowering of serum total cholesterol and particularly of low-density lipoprotein (LDL) cholesterol is important for the prevention of total mortality, coronary artery disease mortality, and major coronary events. The role of serum triglyceride reduction in achievin...
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| Veröffentlicht in: | The American journal of cardiology 1998-02, Vol.81 (4), p.70B-73B |
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| container_title | The American journal of cardiology |
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| creator | Kesaniemi, Y Antero |
| description | Trial evidence shows that effective lowering of serum total cholesterol and particularly of low-density lipoprotein (LDL) cholesterol is important for the prevention of total mortality, coronary artery disease mortality, and major coronary events. The role of serum triglyceride reduction in achieving clinical benefit is unclear and poorly documented. On the other hand, no specific trials have studied the importance of triglyceride lowering among patients with marked hypertriglyceridemia. One of the problems in assessing patients with high serum triglyceride levels may be the heterogeneous background of the molecular mechanisms that result in hypertriglyceridemia. |
| doi_str_mv | 10.1016/S0002-9149(98)00042-3 |
| format | Article |
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The role of serum triglyceride reduction in achieving clinical benefit is unclear and poorly documented. On the other hand, no specific trials have studied the importance of triglyceride lowering among patients with marked hypertriglyceridemia. 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The role of serum triglyceride reduction in achieving clinical benefit is unclear and poorly documented. On the other hand, no specific trials have studied the importance of triglyceride lowering among patients with marked hypertriglyceridemia. 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Vitamins</subject><subject>Humans</subject><subject>Hypertriglyceridemia - blood</subject><subject>Hypertriglyceridemia - drug therapy</subject><subject>Hypolipidemic Agents - administration & dosage</subject><subject>Lipids</subject><subject>Medical sciences</subject><subject>Myocardial Infarction - drug therapy</subject><subject>Myocardial Ischemia - drug therapy</subject><subject>Pharmacology. 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| ispartof | The American journal of cardiology, 1998-02, Vol.81 (4), p.70B-73B |
| issn | 0002-9149 1879-1913 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Anticholesteremic Agents - administration & dosage Bezafibrate - administration & dosage Biological and medical sciences Cardiology Cholesterol Cholesterol, LDL - blood Clinical trials Clinical Trials as Topic Coronary Artery Disease - drug therapy Coronary Disease - prevention & control Estrogen Replacement Therapy Female General and cellular metabolism. Vitamins Humans Hypertriglyceridemia - blood Hypertriglyceridemia - drug therapy Hypolipidemic Agents - administration & dosage Lipids Medical sciences Myocardial Infarction - drug therapy Myocardial Ischemia - drug therapy Pharmacology. Drug treatments Postmenopause Pravastatin - administration & dosage Risk Factors Simvastatin - administration & dosage Triglycerides - blood |
| title | Serum Triglycerides and Clinical Benefit in Lipid-Lowering Trials |
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