Consequences of Aging on Mitochondrial Respiratory Chain Enzymes in Cultured Human Fibroblasts Treated with Ascorbate

The activities of mitochondrial respiratory chain enzymes with and without ascorbate pretreatment were assayed in 10- to 20-week-old cultures of human fibroblasts. Aging was associated with a significant loss of respiratory chain enzyme activities. The presence of ascorbate in the medium reduced the...

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Veröffentlicht in:	Gerontology (Basel) 1998, Vol.44 (2), p.78-84
Hauptverfasser:	Sharma, P., Rupar, C.A., Rip, J.W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Ascorbic Acid - pharmacology Biological and medical sciences Cell structures and functions Cells, Cultured Cellular Senescence - physiology Citrate (si)-Synthase - metabolism Electron Transport - drug effects Electron Transport - physiology Electron Transport Complex II Electron Transport Complex III - metabolism Electron Transport Complex IV - metabolism Experimental Section Fibroblasts - cytology Fibroblasts - enzymology Free Radicals - metabolism Fundamental and applied biological sciences. Psychology Humans Male Mitochondria - drug effects Mitochondria - enzymology Mitochondria and cell respiration Molecular and cellular biology Multienzyme Complexes - metabolism NAD(P)H Dehydrogenase (Quinone) - metabolism Oxidative Stress - physiology Oxidoreductases - metabolism Succinate Dehydrogenase - metabolism
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