Cis-syn thymine dimers are not absolute blocks to replication by DNA polymerase I of Escherichia coli in vitro

Both Escherichia coli DNA polymerase I (pol I) and the large fragment of pol I (Klenow) were found to bypass a site-specific cis-syn thymine dimer, in vitro, under standard conditions. A template was constructed by ligating d(pCGTAT[c,s]TATGC), synthesized via a cis-syn thymine dimer phosphoramidite...

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Veröffentlicht in:	Biochemistry (Easton) 1990-02, Vol.29 (6), p.1624-1632
Hauptverfasser:	Taylor, John Stephen, O'Day, Christine L
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biological and medical sciences DNA Polymerase I - metabolism DNA Replication Escherichia coli Escherichia coli - enzymology Escherichia coli - genetics Fundamental and applied biological sciences. Psychology Molecular and cellular biology Molecular genetics Molecular Sequence Data Mutagenesis. Repair Mutation Oligodeoxyribonucleotides Pyrimidine Dimers - metabolism Templates, Genetic
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