Inheritance of the shared epitope and long-term outcomes of rheumatoid arthritis among community-based Caucasian females

Multiple HLA‐DRB1 alleles encoding a shared epitope (SE) at amino acid positions 70–74 are associated with susceptibility and severity of rheumatoid arthritis (RA). We examined the relationship between the number and DRB1 genotype of SE alleles inherited and long‐term outcomes of 180 community‐based...

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Veröffentlicht in:	Genetic epidemiology 1998, Vol.15 (1), p.61-72
Hauptverfasser:	Criswell, Lindsey A., Mu, Hua, Such, Carol L., King, Mary-Claire
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - immunology Biological and medical sciences California Community Health Services Disabled Persons Diseases of the osteoarticular system Epitopes - genetics European Continental Ancestry Group - genetics Female Follow-Up Studies Genetic Heterogeneity Genotype heterogeneity HLA-DRB1 alleles Humans Inflammatory joint diseases long-term outcomes Medical sciences Middle Aged Models, Genetic Multivariate Analysis rheumatoid arthritis shared epitope Treatment Outcome
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