Effect of cyclic AMP on the cell cycle regulation of ribonucleotide reductase M2 subunit messenger RNA concentrations in wild-type and mutant S49 T lymphoma cells

Ribonucleotide reductase activity in S49 T lymphoma cells is cell cycle regulated by de novo protein synthesis of the M2 subunit. There is maximal enzyme activity in S and G2/M phase with low activity and low concentrations of the M2 subunit in G1 phase. Pharmacologic concentrations of cyclic AMP ar...

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Veröffentlicht in:	Journal of cellular physiology 1990-05, Vol.143 (2), p.251-256
Hauptverfasser:	Albert, Daniel A., Nodzenski, Edwardine, Yim, Gloria, Kowalski, Janice
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blotting, Northern Cell Cycle - drug effects Cell cycle, cell proliferation Cell Line Cell physiology Cyclic AMP - pharmacology Drug Resistance Fundamental and applied biological sciences. Psychology Hydroxyurea - pharmacology In Vitro Techniques Mice Molecular and cellular biology Protein Kinases - physiology Ribonucleotide Reductases - genetics Ribonucleotide Reductases - metabolism RNA, Messenger - genetics T-Lymphocytes - physiology Transcription, Genetic - drug effects Tumor Cells, Cultured
Online-Zugang:	Volltext
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